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Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China.
Medicine (Baltimore). 2020 Jul 17; 99(29):e21334.M

Abstract

RATIONALE

The outbreak of coronavirus disease 2019 (COVID-19) in 2019 has become a global pandemic. It is not known whether the disease is associated with a higher risk of infection in pregnant women or whether intrauterine vertical transmission can occur. We report 2 cases of pregnant women diagnosed with COVID-19.

PATIENT CONCERNS

In all of Yichang city from January 20, 2020, to April 9, 2020, only 2 pregnant women, who were in the late stage of pregnancy, were diagnosed with COVID-19; one patient was admitted for fever with limb asthenia, and the other patient was admitted for abnormal chest computed tomography results.

DIAGNOSES

Both pregnant women were diagnosed with COVID-19.

INTERVENTIONS

After the medical staff prepared for isolation and protection, the 2 pregnant women quickly underwent cesarean sections. A series of tests, such as laboratory, imaging, and SARS-CoV-2 nucleic acid examinations, were performed on the 2 women with COVID-19 and their newborns.

OUTCOMES

One of the 2 infected pregnant women had severe COVID-19, and the other had mild disease. Both babies were delivered by cesarean section. Both of the women with COVID-19 worsened 3 to 6 days after delivery. Chest computed tomography suggested that the lesions due to SARS-CoV-2 infection increased. These women began to exhibit fever or reduced blood oxygen saturation again. One of the 2 newborns was born prematurely, and the other was born at full term. Neither infant was infected with COVID-19, but both had increased prothrombin time and fibrinogen, lactate dehydrogenase, phosphocreatine kinase, and creatine kinase isoenzyme contents.

LESSONS

SARS-CoV-2 infection was not found in the newborns born to the 2 pregnant women with COVID-19, but transient coagulation dysfunction and myocardial damage occurred in the 2 newborns. Effective management strategies for pregnant women with COVID-19 will help to control the outbreak of COVID-19 among pregnant women.

Authors+Show Affiliations

aDepartment of Obstetrics and Gynecology bEmergency Department, The First College of Clinical Medical Science, Yichang Central People's Hospital, Three Gorges University, Yichang, Hubei, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32702930

Citation

Zheng, Tingting, et al. "Coronavirus Disease 2019 (COVID-19) in Pregnancy: 2 Case Reports On Maternal and Neonatal Outcomes in Yichang City, Hubei Province, China." Medicine, vol. 99, no. 29, 2020, pp. e21334.
Zheng T, Guo J, He W, et al. Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China. Medicine (Baltimore). 2020;99(29):e21334.
Zheng, T., Guo, J., He, W., Wang, H., Yu, H., & Ye, H. (2020). Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China. Medicine, 99(29), e21334. https://doi.org/10.1097/MD.0000000000021334
Zheng T, et al. Coronavirus Disease 2019 (COVID-19) in Pregnancy: 2 Case Reports On Maternal and Neonatal Outcomes in Yichang City, Hubei Province, China. Medicine (Baltimore). 2020 Jul 17;99(29):e21334. PubMed PMID: 32702930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China. AU - Zheng,Tingting, AU - Guo,Jianqiang, AU - He,Wencong, AU - Wang,Hao, AU - Yu,Huiling, AU - Ye,Hong, PY - 2020/7/25/entrez PY - 2020/7/25/pubmed PY - 2020/8/1/medline SP - e21334 EP - e21334 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 29 N2 - RATIONALE: The outbreak of coronavirus disease 2019 (COVID-19) in 2019 has become a global pandemic. It is not known whether the disease is associated with a higher risk of infection in pregnant women or whether intrauterine vertical transmission can occur. We report 2 cases of pregnant women diagnosed with COVID-19. PATIENT CONCERNS: In all of Yichang city from January 20, 2020, to April 9, 2020, only 2 pregnant women, who were in the late stage of pregnancy, were diagnosed with COVID-19; one patient was admitted for fever with limb asthenia, and the other patient was admitted for abnormal chest computed tomography results. DIAGNOSES: Both pregnant women were diagnosed with COVID-19. INTERVENTIONS: After the medical staff prepared for isolation and protection, the 2 pregnant women quickly underwent cesarean sections. A series of tests, such as laboratory, imaging, and SARS-CoV-2 nucleic acid examinations, were performed on the 2 women with COVID-19 and their newborns. OUTCOMES: One of the 2 infected pregnant women had severe COVID-19, and the other had mild disease. Both babies were delivered by cesarean section. Both of the women with COVID-19 worsened 3 to 6 days after delivery. Chest computed tomography suggested that the lesions due to SARS-CoV-2 infection increased. These women began to exhibit fever or reduced blood oxygen saturation again. One of the 2 newborns was born prematurely, and the other was born at full term. Neither infant was infected with COVID-19, but both had increased prothrombin time and fibrinogen, lactate dehydrogenase, phosphocreatine kinase, and creatine kinase isoenzyme contents. LESSONS: SARS-CoV-2 infection was not found in the newborns born to the 2 pregnant women with COVID-19, but transient coagulation dysfunction and myocardial damage occurred in the 2 newborns. Effective management strategies for pregnant women with COVID-19 will help to control the outbreak of COVID-19 among pregnant women. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/32702930/Coronavirus_disease_2019__COVID_19__in_pregnancy:_2_case_reports_on_maternal_and_neonatal_outcomes_in_Yichang_city_Hubei_Province_China_ L2 - https://doi.org/10.1097/MD.0000000000021334 DB - PRIME DP - Unbound Medicine ER -