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Promise and challenges in the development of COVID-19 vaccines.
Hum Vaccin Immunother. 2020 11 01; 16(11):2604-2608.HV

Abstract

The pandemic outbreak of COVID-19, caused by coronavirus SARS-CoV-2, created an unprecedented challenge to global public health system and biomedical community. Vaccination is an effective way to prevent viral infection, stop its transmission, and develop herd immunity. Rapid progress and advances have been made to date in the development of COVID-19 vaccines. Currently, more than 115 vaccine candidates have been developed from different technology platforms with several of them in clinical trials. Most of those vaccine candidates are developed based on the experience with other coronaviruses with an aim to induce neutralizing antibodies against the viral spike protein or its different receptor binding domains. Here, we discuss the promise, potential scientific challenges, and future directions for the development of a safe and effective COVID-19 vaccine. We also emphasize the importance of a better understanding of the infection pathogenesis and host defense mechanisms against SARS-CoV-2 infection.

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Authors+Show Affiliations

Chen W
Human Health Therapeutics Research Center (HHT), National Research Council Canada , Ottawa, Ontario, Canada. Department of Biology, Brock University , St. Catharines, Ontario, Canada.

MeSH

Antibody-Dependent EnhancementCOVID-19COVID-19 VaccinesHumansImmunity, HerdSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationViral Load

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32703069

Citation

Chen, Wangxue. "Promise and Challenges in the Development of COVID-19 Vaccines." Human Vaccines & Immunotherapeutics, vol. 16, no. 11, 2020, pp. 2604-2608.
Chen W. Promise and challenges in the development of COVID-19 vaccines. Hum Vaccin Immunother. 2020;16(11):2604-2608.
Chen, W. (2020). Promise and challenges in the development of COVID-19 vaccines. Human Vaccines & Immunotherapeutics, 16(11), 2604-2608. https://doi.org/10.1080/21645515.2020.1787067
Chen W. Promise and Challenges in the Development of COVID-19 Vaccines. Hum Vaccin Immunother. 2020 11 1;16(11):2604-2608. PubMed PMID: 32703069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Promise and challenges in the development of COVID-19 vaccines. A1 - Chen,Wangxue, Y1 - 2020/07/23/ PY - 2020/7/25/pubmed PY - 2020/12/29/medline PY - 2020/7/25/entrez KW - COVID-19 KW - SARS-COV-2 KW - animal model KW - protective immunity KW - safety KW - vaccine SP - 2604 EP - 2608 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 16 IS - 11 N2 - The pandemic outbreak of COVID-19, caused by coronavirus SARS-CoV-2, created an unprecedented challenge to global public health system and biomedical community. Vaccination is an effective way to prevent viral infection, stop its transmission, and develop herd immunity. Rapid progress and advances have been made to date in the development of COVID-19 vaccines. Currently, more than 115 vaccine candidates have been developed from different technology platforms with several of them in clinical trials. Most of those vaccine candidates are developed based on the experience with other coronaviruses with an aim to induce neutralizing antibodies against the viral spike protein or its different receptor binding domains. Here, we discuss the promise, potential scientific challenges, and future directions for the development of a safe and effective COVID-19 vaccine. We also emphasize the importance of a better understanding of the infection pathogenesis and host defense mechanisms against SARS-CoV-2 infection. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/32703069/Promise_and_challenges_in_the_development_of_COVID_19_vaccines_ DB - PRIME DP - Unbound Medicine ER -