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Jejunal mucosal immunoglobulins and complement in untreated coeliac disease.
J Pathol. 1977 Apr; 121(4):219-23.JP

Abstract

Jejunal immunofluorescence studies have shown that there is a significantly increased incidence of extracellular IgA and complement in the basement membrane zone and lamina propria of untreated adult coeliac patients compared to coeliac patients on a gluten-free diet. IgG was also demonstrated with complement, particularly in the untreated patients. These findings, taken together with those of other studies, suggest that a local antibody-antigen reaction involving IgA and complement may be responsible for the ongoing mucosal damage in untreated coeliac disease as well as for the acute damage following gluten challenge of the treated patient. Furthermore, consequent upon this damage there may be a secondary IgG antibody response, possibly reticulin antibody, contributing to the mucosal damage.

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Publisher Full Text

Authors

Scott BB
No affiliation info available
Scott DG
No affiliation info available
Losowsky MS
No affiliation info available

MeSH

AdultBasement MembraneCeliac DiseaseComplement C3Complement System ProteinsDietFluorescent Antibody TechniqueHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunoglobulinsIntestinal MucosaJejunum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

327040

Citation

Scott, B B., et al. "Jejunal Mucosal Immunoglobulins and Complement in Untreated Coeliac Disease." The Journal of Pathology, vol. 121, no. 4, 1977, pp. 219-23.
Scott BB, Scott DG, Losowsky MS. Jejunal mucosal immunoglobulins and complement in untreated coeliac disease. J Pathol. 1977;121(4):219-23.
Scott, B. B., Scott, D. G., & Losowsky, M. S. (1977). Jejunal mucosal immunoglobulins and complement in untreated coeliac disease. The Journal of Pathology, 121(4), 219-23.
Scott BB, Scott DG, Losowsky MS. Jejunal Mucosal Immunoglobulins and Complement in Untreated Coeliac Disease. J Pathol. 1977;121(4):219-23. PubMed PMID: 327040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Jejunal mucosal immunoglobulins and complement in untreated coeliac disease. AU - Scott,B B, AU - Scott,D G, AU - Losowsky,M S, PY - 1977/4/1/pubmed PY - 1977/4/1/medline PY - 1977/4/1/entrez SP - 219 EP - 23 JF - The Journal of pathology JO - J Pathol VL - 121 IS - 4 N2 - Jejunal immunofluorescence studies have shown that there is a significantly increased incidence of extracellular IgA and complement in the basement membrane zone and lamina propria of untreated adult coeliac patients compared to coeliac patients on a gluten-free diet. IgG was also demonstrated with complement, particularly in the untreated patients. These findings, taken together with those of other studies, suggest that a local antibody-antigen reaction involving IgA and complement may be responsible for the ongoing mucosal damage in untreated coeliac disease as well as for the acute damage following gluten challenge of the treated patient. Furthermore, consequent upon this damage there may be a secondary IgG antibody response, possibly reticulin antibody, contributing to the mucosal damage. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/327040/Jejunal_mucosal_immunoglobulins_and_complement_in_untreated_coeliac_disease_ L2 - https://doi.org/10.1002/path.1711210405 DB - PRIME DP - Unbound Medicine ER -