Tags

Type your tag names separated by a space and hit enter

Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application.
Fa Yi Xue Za Zhi. 2020 Jun; 36(3):341-346.FY

Abstract

ABSTRACT

Objective To investigate the allele distribution, population genetics parameters and genetic analysis of neighboring populations of 19 autosomal STR loci in Sichuan Han population, and to evaluate their forensic application value. Methods The Goldeneye?? DNA ID system 20A was used to perform multiplex PCR amplification and allelic gene typing of 19 STR loci in 1 201 unrelated Han individuals from Sichuan Province. Allele frequencies and population genetics parameters were calculated. The Nei's genetic distances between Sichuan Han population and 12 previously reported populations were analyzed. Multidimensional scaling and principal component analysis were carried out and phylogenetic trees were also constructed. Results The heterozygosity of 19 STR loci ranged from 0.617 0 to 0.915 1, their discrimination power ranged from 0.777 4 to 0.986 5, matching probability ranged from 0.013 5 to 0.222 6, polymorphism information content ranged from 0.546 4 to 0.910 5, probability of exclusion ranged from 0.311 8 to 0.826 3 （triplet） and from 0.197 9 to 0.712 1 （biplet）, and no significant deviations from Hardy-Weinberg equilibrium were observed. Based on the results of multidimensional scaling, principal component analysis and phylogenetic trees of the genetic distances between Sichuan Han population and the other 12 populations, Sichuan Han population was closest to Hubei Han population and was farthest to Xinjiang Uygur population. Conclusion The 19 autosomal STR loci showed a high polymorphism and discriminating ability in Sichuan Han population, which can provide a data foundation for personal identification, paternity test and population genetics study.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Huang Y
West China School of Basic Medical Sciences & Forensic Medicine, Chengdu 610041, China. Sichuan Qiushi Forensic Service, Chengdu 610011, China.
Wang YZ
Sichuan Qiushi Forensic Service, Chengdu 610011, China.
Song F
West China School of Basic Medical Sciences & Forensic Medicine, Chengdu 610041, China.

MeSH

Asian PeopleChinaEthnicityGene FrequencyGenetics, PopulationHumansMicrosatellite RepeatsPhylogenyPolymorphism, Genetic

Pub Type(s)

Journal Article

Language

eng chi

PubMed ID

32705847

Citation

Huang, Y, et al. "Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application." Fa Yi Xue Za Zhi, vol. 36, no. 3, 2020, pp. 341-346.
Huang Y, Wang YZ, Song F. Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application. Fa Yi Xue Za Zhi. 2020;36(3):341-346.
Huang, Y., Wang, Y. Z., & Song, F. (2020). Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application. Fa Yi Xue Za Zhi, 36(3), 341-346. https://doi.org/10.12116/j.issn.1004-5619.2020.03.009
Huang Y, Wang YZ, Song F. Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application. Fa Yi Xue Za Zhi. 2020;36(3):341-346. PubMed PMID: 32705847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of 19 Autosomal STR Loci in Sichuan Han Population and Their Forensic Application. AU - Huang,Y, AU - Wang,Y Z, AU - Song,F, PY - 2019/02/22/received PY - 2020/7/25/entrez PY - 2020/7/25/pubmed PY - 2020/11/3/medline KW - forensic genetics; polymorphism, genetic; short tandem repeat; genetics, population; autosome; Han population; Sichuan SP - 341 EP - 346 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 36 IS - 3 N2 - ABSTRACT: Objective To investigate the allele distribution, population genetics parameters and genetic analysis of neighboring populations of 19 autosomal STR loci in Sichuan Han population, and to evaluate their forensic application value. Methods The Goldeneye?? DNA ID system 20A was used to perform multiplex PCR amplification and allelic gene typing of 19 STR loci in 1 201 unrelated Han individuals from Sichuan Province. Allele frequencies and population genetics parameters were calculated. The Nei's genetic distances between Sichuan Han population and 12 previously reported populations were analyzed. Multidimensional scaling and principal component analysis were carried out and phylogenetic trees were also constructed. Results The heterozygosity of 19 STR loci ranged from 0.617 0 to 0.915 1, their discrimination power ranged from 0.777 4 to 0.986 5, matching probability ranged from 0.013 5 to 0.222 6, polymorphism information content ranged from 0.546 4 to 0.910 5, probability of exclusion ranged from 0.311 8 to 0.826 3 （triplet） and from 0.197 9 to 0.712 1 （biplet）, and no significant deviations from Hardy-Weinberg equilibrium were observed. Based on the results of multidimensional scaling, principal component analysis and phylogenetic trees of the genetic distances between Sichuan Han population and the other 12 populations, Sichuan Han population was closest to Hubei Han population and was farthest to Xinjiang Uygur population. Conclusion The 19 autosomal STR loci showed a high polymorphism and discriminating ability in Sichuan Han population, which can provide a data foundation for personal identification, paternity test and population genetics study. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/32705847/Polymorphisms_of_19_Autosomal_STR_Loci_in_Sichuan_Han_Population_and_Their_Forensic_Application_ DB - PRIME DP - Unbound Medicine ER -