Tags

Type your tag names separated by a space and hit enter

The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy.
Diabetes Res Clin Pract. 2020 Aug; 166:108337.DR

Abstract

Charcot neuroarthropathy is a chronic, progressive condition of the skeletal system that affects some patients with diabetic neuropathy. It results in progressive destruction of bones of the foot and disorganisation of pedal joints and ligaments. Effective prevention and treatment for Charcot neuroarthropathy remain a challenge. Currently, there are no reliable repeatable markers to identify patients with diabetes who are at higher risk of developing Charcot neuroarthropathy. The pathogenesis underlying the development of Charcot neuroarthropathy also remains unclear. In this review, we provide an overview of the history, prevalence, symptoms, risk factors, diagnostics and treatment of Charcot neuroarthropathy. We also discuss the potential for OPG and RANKL gene variants to act as predictive markers for the development of Charcot neuroarthropathy. Finally, we summarise the latest research on the role of monocyte-to-osteoclast differentiation in the development of acute Charcot neuroarthropathy.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kloska A
University of Gdańsk, Faculty of Biology, Department of Medical Biology and Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Korzon-Burakowska A
Medical University of Gdańsk, Faculty of Medicine, Department of Hypertension and Diabetology, Dębinki 7, 80-211 Gdańsk, Poland.
Malinowska M
University of Gdańsk, Faculty of Biology, Department of Medical Biology and Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Bruhn-Olszewska B
University of Gdańsk, Faculty of Biology, Department of Bacterial Molecular Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Gabig-Cimińska M
University of Gdańsk, Faculty of Biology, Department of Medical Biology and Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of Molecular Biology, Kładki 24, 80-822 Gdańsk, Poland.
Jakóbkiewicz-Banecka J
University of Gdańsk, Faculty of Biology, Department of Medical Biology and Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland. Electronic address: joanna.jakobkiewicz-banecka@biol.ug.edu.pl.

MeSH

Arthropathy, NeurogenicCell DifferentiationChronic DiseaseDiabetic NeuropathiesFemaleFootHumansMaleMonocytesOsteoclasts

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32707214

Citation

Kloska, Anna, et al. "The Role of Genetic Factors and Monocyte-to-osteoclast Differentiation in the Pathogenesis of Charcot Neuroarthropathy." Diabetes Research and Clinical Practice, vol. 166, 2020, p. 108337.
Kloska A, Korzon-Burakowska A, Malinowska M, et al. The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy. Diabetes Res Clin Pract. 2020;166:108337.
Kloska, A., Korzon-Burakowska, A., Malinowska, M., Bruhn-Olszewska, B., Gabig-Cimińska, M., & Jakóbkiewicz-Banecka, J. (2020). The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy. Diabetes Research and Clinical Practice, 166, 108337. https://doi.org/10.1016/j.diabres.2020.108337
Kloska A, et al. The Role of Genetic Factors and Monocyte-to-osteoclast Differentiation in the Pathogenesis of Charcot Neuroarthropathy. Diabetes Res Clin Pract. 2020;166:108337. PubMed PMID: 32707214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy. AU - Kloska,Anna, AU - Korzon-Burakowska,Anna, AU - Malinowska,Marcelina, AU - Bruhn-Olszewska,Bożena, AU - Gabig-Cimińska,Magdalena, AU - Jakóbkiewicz-Banecka,Joanna, Y1 - 2020/07/21/ PY - 2019/11/11/received PY - 2020/05/07/revised PY - 2020/07/16/accepted PY - 2020/7/25/pubmed PY - 2020/10/21/medline PY - 2020/7/25/entrez KW - Charcot foot KW - Charcot neuroarthropathy KW - OPG KW - Osteoclast differentiation KW - RANKL SP - 108337 EP - 108337 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 166 N2 - Charcot neuroarthropathy is a chronic, progressive condition of the skeletal system that affects some patients with diabetic neuropathy. It results in progressive destruction of bones of the foot and disorganisation of pedal joints and ligaments. Effective prevention and treatment for Charcot neuroarthropathy remain a challenge. Currently, there are no reliable repeatable markers to identify patients with diabetes who are at higher risk of developing Charcot neuroarthropathy. The pathogenesis underlying the development of Charcot neuroarthropathy also remains unclear. In this review, we provide an overview of the history, prevalence, symptoms, risk factors, diagnostics and treatment of Charcot neuroarthropathy. We also discuss the potential for OPG and RANKL gene variants to act as predictive markers for the development of Charcot neuroarthropathy. Finally, we summarise the latest research on the role of monocyte-to-osteoclast differentiation in the development of acute Charcot neuroarthropathy. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/32707214/The_role_of_genetic_factors_and_monocyte_to_osteoclast_differentiation_in_the_pathogenesis_of_Charcot_neuroarthropathy_ DB - PRIME DP - Unbound Medicine ER -