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Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases.
Microorganisms. 2020 Jul 16; 8(7)M

Abstract

The lung microbiome composition has critical implications in the regulation of innate and adaptive immune responses. Next-generation sequencing techniques have revolutionized the understanding of pulmonary physiology and pathology. Currently, it is clear that the lung is not a sterile place; therefore, the investigation of the participation of the pulmonary microbiome in the presentation, severity, and prognosis of multiple pathologies, such as asthma, chronic obstructive pulmonary disease, and interstitial lung diseases, contributes to a better understanding of the pathophysiology. Dysregulation of microbiota components in the microbiome-host interaction is associated with multiple lung pathologies, severity, and prognosis, making microbiome study a useful tool for the identification of potential therapeutic strategies. This review integrates the findings regarding the activation and regulation of the innate and adaptive immune response pathways according to the microbiome, including microbial patterns that could be characteristic of certain diseases. Further studies are required to verify whether the microbial profile and its metabolites can be used as biomarkers of disease progression or poor prognosis and to identify new therapeutic targets that restore lung dysbiosis safely and effectively.

Authors+Show Affiliations

HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32708647

Citation

Lira-Lucio, Juan Alberto, et al. "Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases." Microorganisms, vol. 8, no. 7, 2020.
Lira-Lucio JA, Falfán-Valencia R, Ramírez-Venegas A, et al. Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases. Microorganisms. 2020;8(7).
Lira-Lucio, J. A., Falfán-Valencia, R., Ramírez-Venegas, A., Buendía-Roldán, I., Rojas-Serrano, J., Mejía, M., & Pérez-Rubio, G. (2020). Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases. Microorganisms, 8(7). https://doi.org/10.3390/microorganisms8071059
Lira-Lucio JA, et al. Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases. Microorganisms. 2020 Jul 16;8(7) PubMed PMID: 32708647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases. AU - Lira-Lucio,Juan Alberto, AU - Falfán-Valencia,Ramcés, AU - Ramírez-Venegas,Alejandra, AU - Buendía-Roldán,Ivette, AU - Rojas-Serrano,Jorge, AU - Mejía,Mayra, AU - Pérez-Rubio,Gloria, Y1 - 2020/07/16/ PY - 2020/06/11/received PY - 2020/07/02/revised PY - 2020/07/07/accepted PY - 2020/7/26/entrez PY - 2020/7/28/pubmed PY - 2020/7/28/medline KW - 16S rRNA gene KW - dysbiosis KW - immune response KW - lung microbiome KW - respiratory diseases JF - Microorganisms VL - 8 IS - 7 N2 - The lung microbiome composition has critical implications in the regulation of innate and adaptive immune responses. Next-generation sequencing techniques have revolutionized the understanding of pulmonary physiology and pathology. Currently, it is clear that the lung is not a sterile place; therefore, the investigation of the participation of the pulmonary microbiome in the presentation, severity, and prognosis of multiple pathologies, such as asthma, chronic obstructive pulmonary disease, and interstitial lung diseases, contributes to a better understanding of the pathophysiology. Dysregulation of microbiota components in the microbiome-host interaction is associated with multiple lung pathologies, severity, and prognosis, making microbiome study a useful tool for the identification of potential therapeutic strategies. This review integrates the findings regarding the activation and regulation of the innate and adaptive immune response pathways according to the microbiome, including microbial patterns that could be characteristic of certain diseases. Further studies are required to verify whether the microbial profile and its metabolites can be used as biomarkers of disease progression or poor prognosis and to identify new therapeutic targets that restore lung dysbiosis safely and effectively. SN - 2076-2607 UR - https://www.unboundmedicine.com/medline/citation/32708647/Lung_Microbiome_Participation_in_Local_Immune_Response_Regulation_in_Respiratory_Diseases_ L2 - https://www.mdpi.com/resolver?pii=microorganisms8071059 DB - PRIME DP - Unbound Medicine ER -
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