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A 65-Year-Old Woman with a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented with Acute Renal Failure Due to Infection with SARS-Cov-2.
Am J Case Rep. 2020 Jul 25; 21:e926737.AJ

Abstract

BACKGROUND

Acute kidney injury is one of the most common complications in patients infected with SARS-CoV-2, occurring in up to 7% of cases and increasing to 23% in patients treated in the Intensive Care Unit (ICU). The objective of this report was to describe the clinical case of a patient infected by SARS-CoV-2 who developed acute renal injury, probably secondary to this infection. CASE REPORT On 1 April 2020, a 65-year-old woman presented to the emergency service of the National Institute of Respiratory Diseases, Mexico City, with a 15-day history of dry cough and subjective fever. Finally, the following diagnoses were integrated: Acute renal injury of etiology to be determined (acute chronic kidney disease secondary to T2DM vs. acute renal injury by SARS-CoV-2) and COVID-19. The patient had a typical presentation of severe COVID-19, evidencing all the risk and severity factors for this disease. However, after being admitted to the hospital, she showed evidence of acute renal injury. Although the renal injury may have been due to microangiopathic damage caused by chronic hypertension and diabetes, it is imperative to consider the possibility that such exacerbation contributes to SARS-CoV-2 infection or synergy of multiple factors.

CONCLUSIONS

Every aspect of this pandemic remains unclear. The formulation of hypotheses to explain the physiopathological mechanisms by which this new virus can cause mortality in infected patients may help reduce mortality rates and control the pandemic itself.

Authors+Show Affiliations

Laboratory of Clinical Microbiology, National Institute of Respiratory Diseases (INER), Mexico City, Mexico.National School of Biological Sciences (ENCB), National Polytechnic Institute (IPN), Mexico City, Mexico.Laboratory of Clinical Microbiology, National Institute of Respiratory Diseases (INER), Mexico City, Mexico.Laboratory of Clinical Microbiology, National Institute of Respiratory Diseases (INER), Mexico City, Mexico.Laboratory of Clinical Microbiology, National Institute of Respiratory Diseases (INER), Mexico City, Mexico.Laboratory of Clinical Microbiology, National Institute of Respiratory Diseases (INER), Mexico City, Mexico.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32710735

Citation

Sánchez Tinajero, Ángel, et al. "A 65-Year-Old Woman With a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented With Acute Renal Failure Due to Infection With SARS-Cov-2." The American Journal of Case Reports, vol. 21, 2020, pp. e926737.
Sánchez Tinajero Á, González Cueto E, Martínez Orozco JA, et al. A 65-Year-Old Woman with a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented with Acute Renal Failure Due to Infection with SARS-Cov-2. Am J Case Rep. 2020;21:e926737.
Sánchez Tinajero, Á., González Cueto, E., Martínez Orozco, J. A., Becerril Vargas, E., Ruiz Santillán, D. P., & Reséndiz Escobar, H. (2020). A 65-Year-Old Woman with a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented with Acute Renal Failure Due to Infection with SARS-Cov-2. The American Journal of Case Reports, 21, e926737. https://doi.org/10.12659/AJCR.926737
Sánchez Tinajero Á, et al. A 65-Year-Old Woman With a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented With Acute Renal Failure Due to Infection With SARS-Cov-2. Am J Case Rep. 2020 Jul 25;21:e926737. PubMed PMID: 32710735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 65-Year-Old Woman with a History of Type 2 Diabetes Mellitus and Hypertension and a 15-Day History of Dry Cough and Fever Who Presented with Acute Renal Failure Due to Infection with SARS-Cov-2. AU - Sánchez Tinajero,Ángel, AU - González Cueto,Elizabeth, AU - Martínez Orozco,José A, AU - Becerril Vargas,Eduardo, AU - Ruiz Santillán,Danna P, AU - Reséndiz Escobar,Héctor, Y1 - 2020/07/25/ PY - 2020/7/26/entrez PY - 2020/7/28/pubmed PY - 2020/8/14/medline SP - e926737 EP - e926737 JF - The American journal of case reports JO - Am J Case Rep VL - 21 N2 - BACKGROUND Acute kidney injury is one of the most common complications in patients infected with SARS-CoV-2, occurring in up to 7% of cases and increasing to 23% in patients treated in the Intensive Care Unit (ICU). The objective of this report was to describe the clinical case of a patient infected by SARS-CoV-2 who developed acute renal injury, probably secondary to this infection. CASE REPORT On 1 April 2020, a 65-year-old woman presented to the emergency service of the National Institute of Respiratory Diseases, Mexico City, with a 15-day history of dry cough and subjective fever. Finally, the following diagnoses were integrated: Acute renal injury of etiology to be determined (acute chronic kidney disease secondary to T2DM vs. acute renal injury by SARS-CoV-2) and COVID-19. The patient had a typical presentation of severe COVID-19, evidencing all the risk and severity factors for this disease. However, after being admitted to the hospital, she showed evidence of acute renal injury. Although the renal injury may have been due to microangiopathic damage caused by chronic hypertension and diabetes, it is imperative to consider the possibility that such exacerbation contributes to SARS-CoV-2 infection or synergy of multiple factors. CONCLUSIONS Every aspect of this pandemic remains unclear. The formulation of hypotheses to explain the physiopathological mechanisms by which this new virus can cause mortality in infected patients may help reduce mortality rates and control the pandemic itself. SN - 1941-5923 UR - https://www.unboundmedicine.com/medline/citation/32710735/A_65_Year_Old_Woman_with_a_History_of_Type_2_Diabetes_Mellitus_and_Hypertension_and_a_15_Day_History_of_Dry_Cough_and_Fever_Who_Presented_with_Acute_Renal_Failure_Due_to_Infection_with_SARS_Cov_2_ L2 - https://www.amjcaserep.com/download/index/idArt/926737 DB - PRIME DP - Unbound Medicine ER -