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Pre-conception exposure to THC fails to impact nicotine reward in adult offspring.
Pharmacol Biochem Behav. 2020 10; 197:173001.PB

Abstract

Exposure to environmental stimuli in one generation can produce altered behavioral and neurobiological phenotypes in descendants. Recent work has shown that parental exposure to cannabinoids alters the rewarding properties of other abused drugs in the subsequent generation. However, whether preconception Δ9-tetrahydrocannabinol (THC) administration modifies the affective properties of nicotine in offspring is unknown. To address this question, male and female rats (F0) received THC (0 or 1.5 mg/kg) throughout the adolescent window and were bred on PND 65. In Experiment 1, adult F1-THC and F1-Veh progeny (males and females) underwent nicotine locomotor sensitization procedures during which nicotine (0 or 0.4 mg/kg) was administered every other day for five exposures, and locomotor activity was recorded on each exposure followed by a final nicotine challenge. There was no cross-generational effect of THC on nicotine locomotor sensitization, although acute exposure to nicotine produced greater activity in females relative to males independent of THC history. In Experiment 2, adult F1-THC and F1-Veh progeny (males and females) were implanted with jugular catheters and trained to self-administer nicotine (0.03 mg/kg/infusion). Following acquisition, all subjects were allowed to self-administer nicotine on a number of reinforcement schedules, e.g., FR2, FR5 and PR, followed by dose response and extinction procedures. Across all indices, F1-THC and F1-Veh subjects displayed similar IVSA of nicotine with no sex differences. The fact that there was no evidence of cross-generational effects of THC on nicotine suggests that such effects are drug-specific.

Authors+Show Affiliations

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA. Electronic address: briana.hempel@nih.gov.Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA.Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA.Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA.Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA.Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave NW, Washington, D.C. 20016, USA. Electronic address: alriley@american.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32710886

Citation

Hempel, Briana J., et al. "Pre-conception Exposure to THC Fails to Impact Nicotine Reward in Adult Offspring." Pharmacology, Biochemistry, and Behavior, vol. 197, 2020, p. 173001.
Hempel BJ, Melkumyan M, Crissman ME, et al. Pre-conception exposure to THC fails to impact nicotine reward in adult offspring. Pharmacol Biochem Behav. 2020;197:173001.
Hempel, B. J., Melkumyan, M., Crissman, M. E., Winston, C. A., Madar, J., & Riley, A. L. (2020). Pre-conception exposure to THC fails to impact nicotine reward in adult offspring. Pharmacology, Biochemistry, and Behavior, 197, 173001. https://doi.org/10.1016/j.pbb.2020.173001
Hempel BJ, et al. Pre-conception Exposure to THC Fails to Impact Nicotine Reward in Adult Offspring. Pharmacol Biochem Behav. 2020;197:173001. PubMed PMID: 32710886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-conception exposure to THC fails to impact nicotine reward in adult offspring. AU - Hempel,Briana J, AU - Melkumyan,Mariam, AU - Crissman,Madeline E, AU - Winston,Chloe A, AU - Madar,Jacob, AU - Riley,Anthony L, Y1 - 2020/07/22/ PY - 2020/06/16/received PY - 2020/07/19/accepted PY - 2020/7/28/pubmed PY - 2021/2/9/medline PY - 2020/7/26/entrez KW - Cross-generational KW - Locomotor sensitization KW - Nicotine KW - Self-administration KW - Sex differences KW - THC SP - 173001 EP - 173001 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 197 N2 - Exposure to environmental stimuli in one generation can produce altered behavioral and neurobiological phenotypes in descendants. Recent work has shown that parental exposure to cannabinoids alters the rewarding properties of other abused drugs in the subsequent generation. However, whether preconception Δ9-tetrahydrocannabinol (THC) administration modifies the affective properties of nicotine in offspring is unknown. To address this question, male and female rats (F0) received THC (0 or 1.5 mg/kg) throughout the adolescent window and were bred on PND 65. In Experiment 1, adult F1-THC and F1-Veh progeny (males and females) underwent nicotine locomotor sensitization procedures during which nicotine (0 or 0.4 mg/kg) was administered every other day for five exposures, and locomotor activity was recorded on each exposure followed by a final nicotine challenge. There was no cross-generational effect of THC on nicotine locomotor sensitization, although acute exposure to nicotine produced greater activity in females relative to males independent of THC history. In Experiment 2, adult F1-THC and F1-Veh progeny (males and females) were implanted with jugular catheters and trained to self-administer nicotine (0.03 mg/kg/infusion). Following acquisition, all subjects were allowed to self-administer nicotine on a number of reinforcement schedules, e.g., FR2, FR5 and PR, followed by dose response and extinction procedures. Across all indices, F1-THC and F1-Veh subjects displayed similar IVSA of nicotine with no sex differences. The fact that there was no evidence of cross-generational effects of THC on nicotine suggests that such effects are drug-specific. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/32710886/Pre_conception_exposure_to_THC_fails_to_impact_nicotine_reward_in_adult_offspring_ DB - PRIME DP - Unbound Medicine ER -