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Micronutrients as immunomodulatory tools for COVID-19 management.
Clin Immunol. 2020 11; 220:108545.CI

Abstract

COVID-19 rapidly turned to a global pandemic posing lethal threats to overwhelming health care capabilities, despite its relatively low mortality rate. The clinical respiratory symptoms include dry cough, fever, anosmia, breathing difficulties, and subsequent respiratory failure. No known cure is available for COVID-19. Apart from the anti-viral strategy, the supports of immune effectors and modulation of immunosuppressive mechanisms is the rationale immunomodulation approach in COVID-19 management. Diet and nutrition are essential for healthy immunity. However, a group of micronutrients plays a dominant role in immunomodulation. The deficiency of most nutrients increases the individual susceptibility to virus infection with a tendency for severe clinical presentation. Despite a shred of evidence, the supplementation of a single nutrient is not promising in the general population. Individuals at high-risk for specific nutrient deficiencies likely benefit from supplementation. The individual dietary and nutritional status assessments are critical for determining the comprehensive actions in COVID-19.

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Authors+Show Affiliations

Gasmi A
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Tippairote T
Philosophy Program in Nutrition, Faculty of Medicine, Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok, Thailand; Nutritional and Environmental Medicine Department, BBH Hospital, Bangkok, Thailand.
Mujawdiya PK
Birla Institute of Technology and Science -Pilani, Hyderabad, India.
Peana M
Department of Chemistry and Pharmacy, University of Sassari, Italy.
Menzel A
Laboratoires Réunis, Junglinster, Luxembourg.
Dadar M
Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Gasmi Benahmed A
Académie Internationale de Médecine Dentaire Intégrative, Paris, France.
Bjørklund G
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway. Electronic address: bjorklund@conem.org.

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsCoughDisease ManagementFeverHumansImmunity, CellularImmunity, InnateImmunologic FactorsMicronutrientsOlfaction DisordersPandemicsPneumonia, ViralRespiratory InsufficiencySARS-CoV-2Severity of Illness IndexTrace ElementsVitamins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32710937

Citation

Gasmi, Amin, et al. "Micronutrients as Immunomodulatory Tools for COVID-19 Management." Clinical Immunology (Orlando, Fla.), vol. 220, 2020, p. 108545.
Gasmi A, Tippairote T, Mujawdiya PK, et al. Micronutrients as immunomodulatory tools for COVID-19 management. Clin Immunol. 2020;220:108545.
Gasmi, A., Tippairote, T., Mujawdiya, P. K., Peana, M., Menzel, A., Dadar, M., Gasmi Benahmed, A., & Bjørklund, G. (2020). Micronutrients as immunomodulatory tools for COVID-19 management. Clinical Immunology (Orlando, Fla.), 220, 108545. https://doi.org/10.1016/j.clim.2020.108545
Gasmi A, et al. Micronutrients as Immunomodulatory Tools for COVID-19 Management. Clin Immunol. 2020;220:108545. PubMed PMID: 32710937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Micronutrients as immunomodulatory tools for COVID-19 management. AU - Gasmi,Amin, AU - Tippairote,Torsak, AU - Mujawdiya,Pavan Kumar, AU - Peana,Massimiliano, AU - Menzel,Alain, AU - Dadar,Maryam, AU - Gasmi Benahmed,Asma, AU - Bjørklund,Geir, Y1 - 2020/07/22/ PY - 2020/04/17/received PY - 2020/07/19/revised PY - 2020/07/19/accepted PY - 2020/7/28/pubmed PY - 2020/10/29/medline PY - 2020/7/26/entrez KW - COVID-19 KW - Immunomodulation KW - Nutrients KW - SARs-CoV-2 KW - Trace elements KW - Vitamins SP - 108545 EP - 108545 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 220 N2 - COVID-19 rapidly turned to a global pandemic posing lethal threats to overwhelming health care capabilities, despite its relatively low mortality rate. The clinical respiratory symptoms include dry cough, fever, anosmia, breathing difficulties, and subsequent respiratory failure. No known cure is available for COVID-19. Apart from the anti-viral strategy, the supports of immune effectors and modulation of immunosuppressive mechanisms is the rationale immunomodulation approach in COVID-19 management. Diet and nutrition are essential for healthy immunity. However, a group of micronutrients plays a dominant role in immunomodulation. The deficiency of most nutrients increases the individual susceptibility to virus infection with a tendency for severe clinical presentation. Despite a shred of evidence, the supplementation of a single nutrient is not promising in the general population. Individuals at high-risk for specific nutrient deficiencies likely benefit from supplementation. The individual dietary and nutritional status assessments are critical for determining the comprehensive actions in COVID-19. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/32710937/Micronutrients_as_immunomodulatory_tools_for_COVID_19_management_ DB - PRIME DP - Unbound Medicine ER -