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Alcohol Consumption and the Risk of Prostate Cancer: A Dose-Response Meta-Analysis.
Nutrients. 2020 Jul 23; 12(8)N

Abstract

Alcohol is widely consumed and is known as a major risk factor for several types of cancers. Yet, it is unclear whether alcohol consumption is associated with the risk of prostate cancer (PCa) or not. We conducted linear and non-linear dose-response meta-analyses of cohort studies on alcohol consumption and PCa risk by types of alcohol (total, wine, beer, and liquor) and PCa (non-aggressive and aggressive). Pubmed and Embase were searched through April 2020 to identify relevant studies. Summary relative risk (RR) and 95% confidence interval (CI) were estimated using a random-effects model. For non-aggressive PCa, by alcohol type, the risk increased linearly with liquor (RR per 14 g/day intake (alcohol content in standard drink) being 1.04 (95% CI = 1.02-1.06, I2 = 0%, three studies) and non-linearly with beer (Pnon-linearity = 0.045, four studies), with increased risk observed in the lower range (RR = 1.03, 95% CI = 1.01-1.05; 14 g/day), with 1.05 (95% CI = 1.01-1.08) at 28 g/day. Wine was not significantly associated with the risk of non-aggressive PCa. For aggressive PCa, a non-linear relationship of diverse shapes was indicated for all types of alcohol in the sensitivity analysis. Compared to non-drinking, a significant positive association was more apparent at lower dose for liquor (RR = 1.12, 95% CI = 1.04-1.20 at 14 g/day; RR = 1.16, 95% CI = 1.03-1.31 at 28 g/day; Pnon-linearity = 0.005, three studies) but at higher doses for wine (RR = 1.02, 95% CI = 0.90-1.16 at 28 g/day, RR = 1.35, 95% CI = 1.08-1.67 at 56 g/day; Pnon-linearity = 0.01, four studies). In contrast, decreased risks were indicated at lower doses of beer (RR = 0.85, 95% CI = 0.79-0.92 at 14 g/day; RR = 0.79, 95% CI = 0.70-0.90 at 28 g/day, Pnon-linearity < 0.001, four studies). Total alcohol consumption was not associated with both types of PCa. In this study, we found heterogeneous associations between alcohol intake and PCa by types of alcohol and PCa.

Authors+Show Affiliations

Department of Food Science and Biotechnology, Dongguk University, Goyang 10325, Korea.Department of Food Science and Biotechnology, Dongguk University, Goyang 10325, Korea.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA.Department of Food Science and Biotechnology, Dongguk University, Goyang 10325, Korea. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02138, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32717903

Citation

Hong, SungEun, et al. "Alcohol Consumption and the Risk of Prostate Cancer: a Dose-Response Meta-Analysis." Nutrients, vol. 12, no. 8, 2020.
Hong S, Khil H, Lee DH, et al. Alcohol Consumption and the Risk of Prostate Cancer: A Dose-Response Meta-Analysis. Nutrients. 2020;12(8).
Hong, S., Khil, H., Lee, D. H., Keum, N., & Giovannucci, E. L. (2020). Alcohol Consumption and the Risk of Prostate Cancer: A Dose-Response Meta-Analysis. Nutrients, 12(8). https://doi.org/10.3390/nu12082188
Hong S, et al. Alcohol Consumption and the Risk of Prostate Cancer: a Dose-Response Meta-Analysis. Nutrients. 2020 Jul 23;12(8) PubMed PMID: 32717903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol Consumption and the Risk of Prostate Cancer: A Dose-Response Meta-Analysis. AU - Hong,SungEun, AU - Khil,Hayeong, AU - Lee,Dong Hoon, AU - Keum,NaNa, AU - Giovannucci,Edward L, Y1 - 2020/07/23/ PY - 2020/06/12/received PY - 2020/07/17/revised PY - 2020/07/21/accepted PY - 2020/7/29/entrez PY - 2020/7/29/pubmed PY - 2021/3/16/medline KW - alcohol consumption KW - alcohol intake KW - cohort study KW - dose-response KW - meta-analysis KW - prostate cancer JF - Nutrients JO - Nutrients VL - 12 IS - 8 N2 - Alcohol is widely consumed and is known as a major risk factor for several types of cancers. Yet, it is unclear whether alcohol consumption is associated with the risk of prostate cancer (PCa) or not. We conducted linear and non-linear dose-response meta-analyses of cohort studies on alcohol consumption and PCa risk by types of alcohol (total, wine, beer, and liquor) and PCa (non-aggressive and aggressive). Pubmed and Embase were searched through April 2020 to identify relevant studies. Summary relative risk (RR) and 95% confidence interval (CI) were estimated using a random-effects model. For non-aggressive PCa, by alcohol type, the risk increased linearly with liquor (RR per 14 g/day intake (alcohol content in standard drink) being 1.04 (95% CI = 1.02-1.06, I2 = 0%, three studies) and non-linearly with beer (Pnon-linearity = 0.045, four studies), with increased risk observed in the lower range (RR = 1.03, 95% CI = 1.01-1.05; 14 g/day), with 1.05 (95% CI = 1.01-1.08) at 28 g/day. Wine was not significantly associated with the risk of non-aggressive PCa. For aggressive PCa, a non-linear relationship of diverse shapes was indicated for all types of alcohol in the sensitivity analysis. Compared to non-drinking, a significant positive association was more apparent at lower dose for liquor (RR = 1.12, 95% CI = 1.04-1.20 at 14 g/day; RR = 1.16, 95% CI = 1.03-1.31 at 28 g/day; Pnon-linearity = 0.005, three studies) but at higher doses for wine (RR = 1.02, 95% CI = 0.90-1.16 at 28 g/day, RR = 1.35, 95% CI = 1.08-1.67 at 56 g/day; Pnon-linearity = 0.01, four studies). In contrast, decreased risks were indicated at lower doses of beer (RR = 0.85, 95% CI = 0.79-0.92 at 14 g/day; RR = 0.79, 95% CI = 0.70-0.90 at 28 g/day, Pnon-linearity < 0.001, four studies). Total alcohol consumption was not associated with both types of PCa. In this study, we found heterogeneous associations between alcohol intake and PCa by types of alcohol and PCa. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32717903/Alcohol_Consumption_and_the_Risk_of_Prostate_Cancer:_A_Dose_Response_Meta_Analysis_ L2 - https://www.mdpi.com/resolver?pii=nu12082188 DB - PRIME DP - Unbound Medicine ER -