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Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis.
J Craniomaxillofac Surg. 2020 Sep; 48(9):902-913.JC

Abstract

A systematic review and network meta-analysis was carried out to assess the efficacy of different intrasocket interventions immediately after mandibular third molar surgery to prevent alveolar osteitis (AO). An electronic search was undertaken using EMBASE, Cochrane Library, MEDLINE/PubMed, Web of Science, Scopus, LILACS, and grey literature. We reviewed studies published up to September 2019 and included 37 randomized controlled trials (6175 mandibular third molar surgeries in 4716 patients). The pairwise meta-analysis showed that the incidence of AO decreased significantly when an intrasocket intervention was performed (risk ratio 0.39 [0.30, 0.52]; p < 0.0001). Platelet-rich fibrin (odds ratio 0.28; 95% CI [0.10, 0.71]), chlorhexidine gel 0.2% (0.52 [0.32, 0.95]), eugenol paste (0.06 [0.00, 0.77]), recombinant bovine growth factor (0.07 [0.00, 0.97]), colloidal silver gelatin sponge (0.05 [0.00, 0.74]), and acellular dermal matrix (0.04 [0.00, 0.74]) were significantly more effective than the placebo. Platelet-rich fibrin and chlorhexidine 0.2% gel had a large number of included studies and patients per comparison. Overall, there was moderate evidence to support the use of platelet-rich fibrin or chlorhexidine 0.2% gel in the socket for the prevention of AO after mandibular third molar surgery.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. Electronic address: drcanellas@icloud.com.Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32718882

Citation

Canellas, João Vitor Dos Santos, et al. "Intrasocket Interventions to Prevent Alveolar Osteitis After Mandibular Third Molar Surgery: a Systematic Review and Network Meta-analysis." Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, vol. 48, no. 9, 2020, pp. 902-913.
Canellas JVDS, Fraga SRG, Santoro MF, et al. Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis. J Craniomaxillofac Surg. 2020;48(9):902-913.
Canellas, J. V. D. S., Fraga, S. R. G., Santoro, M. F., Netto, J. N. S., & Tinoco, E. M. B. (2020). Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis. Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, 48(9), 902-913. https://doi.org/10.1016/j.jcms.2020.06.012
Canellas JVDS, et al. Intrasocket Interventions to Prevent Alveolar Osteitis After Mandibular Third Molar Surgery: a Systematic Review and Network Meta-analysis. J Craniomaxillofac Surg. 2020;48(9):902-913. PubMed PMID: 32718882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis. AU - Canellas,João Vitor Dos Santos, AU - Fraga,Samira Regina Guimarães, AU - Santoro,Monike Fernandes, AU - Netto,Juliana de Noronha Santos, AU - Tinoco,Eduardo Muniz Barretto, Y1 - 2020/07/08/ PY - 2019/12/12/received PY - 2020/05/18/revised PY - 2020/06/28/accepted PY - 2020/7/29/pubmed PY - 2020/9/18/medline PY - 2020/7/29/entrez KW - Alveolar osteitis KW - Dry socket KW - Evidence-based dentistry KW - Network meta-analysis KW - Third molar SP - 902 EP - 913 JF - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JO - J Craniomaxillofac Surg VL - 48 IS - 9 N2 - A systematic review and network meta-analysis was carried out to assess the efficacy of different intrasocket interventions immediately after mandibular third molar surgery to prevent alveolar osteitis (AO). An electronic search was undertaken using EMBASE, Cochrane Library, MEDLINE/PubMed, Web of Science, Scopus, LILACS, and grey literature. We reviewed studies published up to September 2019 and included 37 randomized controlled trials (6175 mandibular third molar surgeries in 4716 patients). The pairwise meta-analysis showed that the incidence of AO decreased significantly when an intrasocket intervention was performed (risk ratio 0.39 [0.30, 0.52]; p < 0.0001). Platelet-rich fibrin (odds ratio 0.28; 95% CI [0.10, 0.71]), chlorhexidine gel 0.2% (0.52 [0.32, 0.95]), eugenol paste (0.06 [0.00, 0.77]), recombinant bovine growth factor (0.07 [0.00, 0.97]), colloidal silver gelatin sponge (0.05 [0.00, 0.74]), and acellular dermal matrix (0.04 [0.00, 0.74]) were significantly more effective than the placebo. Platelet-rich fibrin and chlorhexidine 0.2% gel had a large number of included studies and patients per comparison. Overall, there was moderate evidence to support the use of platelet-rich fibrin or chlorhexidine 0.2% gel in the socket for the prevention of AO after mandibular third molar surgery. SN - 1878-4119 UR - https://www.unboundmedicine.com/medline/citation/32718882/Intrasocket_interventions_to_prevent_alveolar_osteitis_after_mandibular_third_molar_surgery:_A_systematic_review_and_network_meta-analysis. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1010-5182(20)30157-8 DB - PRIME DP - Unbound Medicine ER -