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Hybrid PET/MRI in non-small cell lung cancer (NSCLC) and lung nodules-a literature review.
Eur J Nucl Med Mol Imaging. 2020 Jul 27 [Online ahead of print]EJ

Abstract

BACKGROUND

The use of hybrid PET/MRI for clinical staging is growing in several cancer forms and, consequently, PET/MRI has also gained interest in the assessment of non-small cell lung cancer (NSCLC) and lung lesions. However, lung evaluation with PET/MRI is associated with challenges related to technical issues and diagnostic image quality. We, therefore, investigated the published literature on PET/MRI for clinical staging in NSCLC or lung nodule detection specifically addressing diagnostic accuracy and technical issues.

METHODS

The data originates from a systematic search performed in PubMed/MEDLINE, Embase, and Cochrane Library on hybrid PET/MRI in patients with cancer for a scoping review published earlier (https://doi.org/10.1007/s00259-019-04402-8). Studies in English and German evaluating the diagnostic performance of hybrid PET/MRI for NSCLC or lung nodule detection in cancer patients were selected. Data reported in peer-reviewed journals without restrictions to year of publication were included.

RESULTS

A total of 3138 publications were identified from which 116 published 2012-2018 were included. Of these, nine studies addressed PET/MRI in NSCLC (4) or lung nodule detection (5). Overall, PET/MRI did not provide advantages in preoperative T- and N-staging in NSCLC compared to PET/CT. The data on M-staging were too few for conclusions to be drawn. The lung nodule detection rate of PET/MRI was comparable to that of PET/CT for FDG-avid nodules larger than 10 mm, but the sensitivity of PET/MRI for detection of non-FDG-avid nodules smaller than 5 mm was low.

CONCLUSION

PET/MRI did not provide advantages in T- and N-staging of NSCLC compared to PET/CT. PET/MRI had a comparable sensitivity for detection of FDG-avid lung nodules and nodules over 10 mm, but PET/CT yielded a higher detection rate in non FDG-avid lung nodules under 5 mm. With PET/MRI, the overall detection rate for lung nodules in various cancer types remains inferior to that of PET/CT due to the lower diagnostic performance of MRI than CT in the lungs.

Authors+Show Affiliations

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. sarawallenius@hotmail.com.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Centre for Innovative Medical Technology (CIMT), Odense University Hospital, Odense, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.MAgNetic resonance Technology for Response Adapted radiotherapy (MANTRA), Odense University Hospital, Odense, Denmark. Novo Nordisk A/S, Soeborg, Denmark.Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. MAgNetic resonance Technology for Response Adapted radiotherapy (MANTRA), Odense University Hospital, Odense, Denmark.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32719914

Citation

Dahlsgaard-Wallenius, Sara E., et al. "Hybrid PET/MRI in Non-small Cell Lung Cancer (NSCLC) and Lung Nodules-a Literature Review." European Journal of Nuclear Medicine and Molecular Imaging, 2020.
Dahlsgaard-Wallenius SE, Hildebrandt MG, Johansen A, et al. Hybrid PET/MRI in non-small cell lung cancer (NSCLC) and lung nodules-a literature review. Eur J Nucl Med Mol Imaging. 2020.
Dahlsgaard-Wallenius, S. E., Hildebrandt, M. G., Johansen, A., Vilstrup, M. H., Petersen, H., Gerke, O., Høilund-Carlsen, P. F., Morsing, A., & Andersen, T. L. (2020). Hybrid PET/MRI in non-small cell lung cancer (NSCLC) and lung nodules-a literature review. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-020-04955-z
Dahlsgaard-Wallenius SE, et al. Hybrid PET/MRI in Non-small Cell Lung Cancer (NSCLC) and Lung Nodules-a Literature Review. Eur J Nucl Med Mol Imaging. 2020 Jul 27; PubMed PMID: 32719914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hybrid PET/MRI in non-small cell lung cancer (NSCLC) and lung nodules-a literature review. AU - Dahlsgaard-Wallenius,Sara E, AU - Hildebrandt,Malene Grubbe, AU - Johansen,Allan, AU - Vilstrup,Mie Holm, AU - Petersen,Henrik, AU - Gerke,Oke, AU - Høilund-Carlsen,Poul Flemming, AU - Morsing,Anni, AU - Andersen,Thomas Lund, Y1 - 2020/07/27/ PY - 2019/12/18/received PY - 2020/07/07/accepted PY - 2020/7/29/entrez KW - 18F-FDG KW - Lung lesions KW - NSCLC KW - PET/CT KW - PET/MRI JF - European journal of nuclear medicine and molecular imaging JO - Eur. J. Nucl. Med. Mol. Imaging N2 - BACKGROUND: The use of hybrid PET/MRI for clinical staging is growing in several cancer forms and, consequently, PET/MRI has also gained interest in the assessment of non-small cell lung cancer (NSCLC) and lung lesions. However, lung evaluation with PET/MRI is associated with challenges related to technical issues and diagnostic image quality. We, therefore, investigated the published literature on PET/MRI for clinical staging in NSCLC or lung nodule detection specifically addressing diagnostic accuracy and technical issues. METHODS: The data originates from a systematic search performed in PubMed/MEDLINE, Embase, and Cochrane Library on hybrid PET/MRI in patients with cancer for a scoping review published earlier (https://doi.org/10.1007/s00259-019-04402-8). Studies in English and German evaluating the diagnostic performance of hybrid PET/MRI for NSCLC or lung nodule detection in cancer patients were selected. Data reported in peer-reviewed journals without restrictions to year of publication were included. RESULTS: A total of 3138 publications were identified from which 116 published 2012-2018 were included. Of these, nine studies addressed PET/MRI in NSCLC (4) or lung nodule detection (5). Overall, PET/MRI did not provide advantages in preoperative T- and N-staging in NSCLC compared to PET/CT. The data on M-staging were too few for conclusions to be drawn. The lung nodule detection rate of PET/MRI was comparable to that of PET/CT for FDG-avid nodules larger than 10 mm, but the sensitivity of PET/MRI for detection of non-FDG-avid nodules smaller than 5 mm was low. CONCLUSION: PET/MRI did not provide advantages in T- and N-staging of NSCLC compared to PET/CT. PET/MRI had a comparable sensitivity for detection of FDG-avid lung nodules and nodules over 10 mm, but PET/CT yielded a higher detection rate in non FDG-avid lung nodules under 5 mm. With PET/MRI, the overall detection rate for lung nodules in various cancer types remains inferior to that of PET/CT due to the lower diagnostic performance of MRI than CT in the lungs. SN - 1619-7089 UR - https://www.unboundmedicine.com/medline/citation/32719914/Hybrid_PET/MRI_in_non_small_cell_lung_cancer__NSCLC__and_lung_nodules_a_literature_review_ L2 - https://dx.doi.org/10.1007/s00259-020-04955-z DB - PRIME DP - Unbound Medicine ER -
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