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COVID-19 and Kidney Disease: Update on Epidemiology, Clinical Manifestations, Pathophysiology and Management.
J Coll Physicians Surg Pak. 2020 Jun; 30(6):19-25.JC

Abstract

Acute kidney injury (AKI) is relatively common in critically ill coronavirus disease 2019 (COVID-19) patients and it increases mortality and prolongs hospital stay. This article aimed to investigate the history, virology, epidemiology, clinical manifestations, pathophysiology and management of COVID-19 disease, in general, and the pathogenetic mechanisms of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV2)-induced kidney damage, in particular. Keywords like SARS-CoV2, COVID-19, renal impairment, sepsis, viremia, etc. were used to find relevant publications from PubMed, Scopus, Google Scholar, and clinical trials registry websites. According to different studies, kidney involvement in COVID-19 typically occurs in patients who develop acute respiratory distress syndrome (ARDS) or multiorgan failure. The kidney damage in COVID-19 has been shown to be multifactorial, involving direct viral infection, indirect injury by sepsis, hemodynamic alterations, cytokine storm, disseminated intravascular coagulation and other unknown mechanisms. The presence in kidney of angiotensin-converting enzyme 2 (ACE2), a receptor for the virus, has been proven, but few cases of direct viral presence in kidney tissue have been published. Therefore, further studies are needed to investigate the exact mechanisms underlying kidney impairment. Since the development of AKI is one of the important risk factors for mortality in COVID-19 patients, optimal management of AKI may improve the outcomes. Key Words: Acute kidney injury, Angiotensin-converting enzyme, Sepsis, Cytokine storm, Kidney replacement therapy, Coronavirus disease 2019.

Authors+Show Affiliations

Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.Javed I Kazi Department of Histopathology, SIUT, Karachi, Pakistan.Department of Nephrology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32723443

Citation

Asgharpour, Masoumeh, et al. "COVID-19 and Kidney Disease: Update On Epidemiology, Clinical Manifestations, Pathophysiology and Management." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 30, no. 6, 2020, pp. 19-25.
Asgharpour M, Zare E, Mubarak M, et al. COVID-19 and Kidney Disease: Update on Epidemiology, Clinical Manifestations, Pathophysiology and Management. J Coll Physicians Surg Pak. 2020;30(6):19-25.
Asgharpour, M., Zare, E., Mubarak, M., & Alirezaei, A. (2020). COVID-19 and Kidney Disease: Update on Epidemiology, Clinical Manifestations, Pathophysiology and Management. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 30(6), 19-25. https://doi.org/10.29271/jcpsp.2020.Supp1.S19
Asgharpour M, et al. COVID-19 and Kidney Disease: Update On Epidemiology, Clinical Manifestations, Pathophysiology and Management. J Coll Physicians Surg Pak. 2020;30(6):19-25. PubMed PMID: 32723443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and Kidney Disease: Update on Epidemiology, Clinical Manifestations, Pathophysiology and Management. AU - Asgharpour,Masoumeh, AU - Zare,Elham, AU - Mubarak,Muhammed, AU - Alirezaei,Amirhesam, PY - 2020/05/19/received PY - 2020/06/17/accepted PY - 2020/7/30/entrez PY - 2020/7/30/pubmed PY - 2020/9/8/medline SP - 19 EP - 25 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 30 IS - 6 N2 - Acute kidney injury (AKI) is relatively common in critically ill coronavirus disease 2019 (COVID-19) patients and it increases mortality and prolongs hospital stay. This article aimed to investigate the history, virology, epidemiology, clinical manifestations, pathophysiology and management of COVID-19 disease, in general, and the pathogenetic mechanisms of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV2)-induced kidney damage, in particular. Keywords like SARS-CoV2, COVID-19, renal impairment, sepsis, viremia, etc. were used to find relevant publications from PubMed, Scopus, Google Scholar, and clinical trials registry websites. According to different studies, kidney involvement in COVID-19 typically occurs in patients who develop acute respiratory distress syndrome (ARDS) or multiorgan failure. The kidney damage in COVID-19 has been shown to be multifactorial, involving direct viral infection, indirect injury by sepsis, hemodynamic alterations, cytokine storm, disseminated intravascular coagulation and other unknown mechanisms. The presence in kidney of angiotensin-converting enzyme 2 (ACE2), a receptor for the virus, has been proven, but few cases of direct viral presence in kidney tissue have been published. Therefore, further studies are needed to investigate the exact mechanisms underlying kidney impairment. Since the development of AKI is one of the important risk factors for mortality in COVID-19 patients, optimal management of AKI may improve the outcomes. Key Words: Acute kidney injury, Angiotensin-converting enzyme, Sepsis, Cytokine storm, Kidney replacement therapy, Coronavirus disease 2019. SN - 1681-7168 UR - https://www.unboundmedicine.com/medline/citation/32723443/COVID_19_and_Kidney_Disease:_Update_on_Epidemiology_Clinical_Manifestations_Pathophysiology_and_Management_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -