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Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections.
Int J Infect Dis. 2020 Oct; 99:19-22.IJ

Abstract

This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance in 57 patients with asymptomatic/mild SARS-CoV-2 infection. Patients with olfactory/taste disorders (OTDs) exhibited lower qPCR Ct values and longer time to negative qPCR than those without OTDs, suggesting an association between OTDs and high viral burden.

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Authors+Show Affiliations

Nakagawara K
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Masaki K
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan. Electronic address: masakik@keio.jp.
Uwamino Y
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan; Department of Laboratory Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Kabata H
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Uchida S
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Uno S
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Asakura T
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Funakoshi T
Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Kanzaki S
Department of Otorhinolaryngology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Ishii M
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Hasegawa N
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Fukunaga K
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Keio Donner Project
No affiliation info available

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsFemaleHumansMaleMiddle AgedOlfaction DisordersPandemicsPneumonia, ViralReal-Time Polymerase Chain ReactionSARS-CoV-2Taste DisordersViral Load

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32726723

Citation

Nakagawara, Kensuke, et al. "Acute Onset Olfactory/taste Disorders Are Associated With a High Viral Burden in Mild or Asymptomatic SARS-CoV-2 Infections." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 99, 2020, pp. 19-22.
Nakagawara K, Masaki K, Uwamino Y, et al. Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. Int J Infect Dis. 2020;99:19-22.
Nakagawara, K., Masaki, K., Uwamino, Y., Kabata, H., Uchida, S., Uno, S., Asakura, T., Funakoshi, T., Kanzaki, S., Ishii, M., Hasegawa, N., & Fukunaga, K. (2020). Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 99, 19-22. https://doi.org/10.1016/j.ijid.2020.07.034
Nakagawara K, et al. Acute Onset Olfactory/taste Disorders Are Associated With a High Viral Burden in Mild or Asymptomatic SARS-CoV-2 Infections. Int J Infect Dis. 2020;99:19-22. PubMed PMID: 32726723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. AU - Nakagawara,Kensuke, AU - Masaki,Katsunori, AU - Uwamino,Yoshifumi, AU - Kabata,Hiroki, AU - Uchida,Sho, AU - Uno,Shunsuke, AU - Asakura,Takanori, AU - Funakoshi,Takeru, AU - Kanzaki,Sho, AU - Ishii,Makoto, AU - Hasegawa,Naoki, AU - Fukunaga,Koichi, AU - ,, Y1 - 2020/07/26/ PY - 2020/06/17/received PY - 2020/07/17/revised PY - 2020/07/21/accepted PY - 2020/7/30/pubmed PY - 2020/10/24/medline PY - 2020/7/30/entrez KW - COVID-19 KW - Cycle threshold (Ct) values KW - Olfactory/taste disorders (OTDs) KW - Real-time polymerase chain reaction (qPCR) KW - SARS-CoV-2 SP - 19 EP - 22 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 99 N2 - This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance in 57 patients with asymptomatic/mild SARS-CoV-2 infection. Patients with olfactory/taste disorders (OTDs) exhibited lower qPCR Ct values and longer time to negative qPCR than those without OTDs, suggesting an association between OTDs and high viral burden. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/32726723/Acute_onset_olfactory/taste_disorders_are_associated_with_a_high_viral_burden_in_mild_or_asymptomatic_SARS_CoV_2_infections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(20)30578-6 DB - PRIME DP - Unbound Medicine ER -