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Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections.
Int J Infect Dis. 2020 Oct; 99:19-22.IJ

Abstract

This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance in 57 patients with asymptomatic/mild SARS-CoV-2 infection. Patients with olfactory/taste disorders (OTDs) exhibited lower qPCR Ct values and longer time to negative qPCR than those without OTDs, suggesting an association between OTDs and high viral burden.

Authors+Show Affiliations

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan. Electronic address: masakik@keio.jp.Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan; Department of Laboratory Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Department of Otorhinolaryngology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Department of Infectious Diseases, Keio University School of Medicine, Shinjuku, Tokyo, Japan.Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32726723

Citation

Nakagawara, Kensuke, et al. "Acute Onset Olfactory/taste Disorders Are Associated With a High Viral Burden in Mild or Asymptomatic SARS-CoV-2 Infections." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 99, 2020, pp. 19-22.
Nakagawara K, Masaki K, Uwamino Y, et al. Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. Int J Infect Dis. 2020;99:19-22.
Nakagawara, K., Masaki, K., Uwamino, Y., Kabata, H., Uchida, S., Uno, S., Asakura, T., Funakoshi, T., Kanzaki, S., Ishii, M., Hasegawa, N., & Fukunaga, K. (2020). Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 99, 19-22. https://doi.org/10.1016/j.ijid.2020.07.034
Nakagawara K, et al. Acute Onset Olfactory/taste Disorders Are Associated With a High Viral Burden in Mild or Asymptomatic SARS-CoV-2 Infections. Int J Infect Dis. 2020;99:19-22. PubMed PMID: 32726723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections. AU - Nakagawara,Kensuke, AU - Masaki,Katsunori, AU - Uwamino,Yoshifumi, AU - Kabata,Hiroki, AU - Uchida,Sho, AU - Uno,Shunsuke, AU - Asakura,Takanori, AU - Funakoshi,Takeru, AU - Kanzaki,Sho, AU - Ishii,Makoto, AU - Hasegawa,Naoki, AU - Fukunaga,Koichi, AU - ,, Y1 - 2020/07/26/ PY - 2020/06/17/received PY - 2020/07/17/revised PY - 2020/07/21/accepted PY - 2020/7/30/pubmed PY - 2020/10/24/medline PY - 2020/7/30/entrez KW - COVID-19 KW - Cycle threshold (Ct) values KW - Olfactory/taste disorders (OTDs) KW - Real-time polymerase chain reaction (qPCR) KW - SARS-CoV-2 SP - 19 EP - 22 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 99 N2 - This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance in 57 patients with asymptomatic/mild SARS-CoV-2 infection. Patients with olfactory/taste disorders (OTDs) exhibited lower qPCR Ct values and longer time to negative qPCR than those without OTDs, suggesting an association between OTDs and high viral burden. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/32726723/Acute_onset_olfactory/taste_disorders_are_associated_with_a_high_viral_burden_in_mild_or_asymptomatic_SARS_CoV_2_infections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(20)30578-6 DB - PRIME DP - Unbound Medicine ER -