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Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats.
Nutrients. 2020 Jul 27; 12(8)N

Abstract

Polygonum cuspidatum is widely used as food and medicine in Korea, China, and Japan. Its major bioactive components, resveratrol and emodin, reportedly protect against gastric lesions. We therefore aimed to investigate: (1) the gastroprotective effects of P. cuspidatum roots in hydrochloric acid/ethanol (HCl/EtOH)- and indomethacin-induced acute gastric ulcer rat models; (2) the healing effects in an acetic acid-induced ulcer model; and (3) potential mechanisms by measuring gastric acid secretion-related parameters in a pyloric ligation-induced ulcer model, and by measuring antioxidant enzyme and prostaglandin E2 levels in the gastric tissue of HCl/EtOH-treated rats. Oral administration of P. cuspidatum extract (PCE) at doses of 100 and 300 mg/kg significantly decreased HCl/EtOH- and indomethacin-induced gastric lesions. PCE at 300 mg/kg significantly reduced gastric lesions in acetic acid-induced ulcers. PCE increased superoxide dismutase (SOD)activity and glutathione(GSH) and prostaglandin E2 levels in gastric tissue, whereas it did not alter gastric acid secretion-related parameters. Our findings indicate that PCE has gastroprotective effects against HCl/EtOH and non-steroidal anti-inflammatory drugs(NSAIDs) and promotes healing of acetic acid-induced ulcers. These gastric mucosal protection and ulcer healing effects are associated with antioxidant effects and the augmentation of prostaglandin E2 and suggest that P. cuspidatum might be a promising preventive and therapeutic agent for treating gastric ulcers.

Authors+Show Affiliations

Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32727104

Citation

Kim, Young-Sik, et al. "Gastroprotective and Healing Effects of Polygonum Cuspidatum Root On Experimentally Induced Gastric Ulcers in Rats." Nutrients, vol. 12, no. 8, 2020.
Kim YS, Nam Y, Song J, et al. Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats. Nutrients. 2020;12(8).
Kim, Y. S., Nam, Y., Song, J., & Kim, H. (2020). Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats. Nutrients, 12(8). https://doi.org/10.3390/nu12082241
Kim YS, et al. Gastroprotective and Healing Effects of Polygonum Cuspidatum Root On Experimentally Induced Gastric Ulcers in Rats. Nutrients. 2020 Jul 27;12(8) PubMed PMID: 32727104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats. AU - Kim,Young-Sik, AU - Nam,YunSeol, AU - Song,Jungbin, AU - Kim,Hocheol, Y1 - 2020/07/27/ PY - 2020/06/16/received PY - 2020/07/20/revised PY - 2020/07/23/accepted PY - 2020/7/31/entrez PY - 2020/7/31/pubmed PY - 2021/3/16/medline KW - Polygonum cuspidatum KW - antioxidant KW - gastric acid KW - gastric ulcer KW - gastritis KW - prostaglandin E2 JF - Nutrients JO - Nutrients VL - 12 IS - 8 N2 - Polygonum cuspidatum is widely used as food and medicine in Korea, China, and Japan. Its major bioactive components, resveratrol and emodin, reportedly protect against gastric lesions. We therefore aimed to investigate: (1) the gastroprotective effects of P. cuspidatum roots in hydrochloric acid/ethanol (HCl/EtOH)- and indomethacin-induced acute gastric ulcer rat models; (2) the healing effects in an acetic acid-induced ulcer model; and (3) potential mechanisms by measuring gastric acid secretion-related parameters in a pyloric ligation-induced ulcer model, and by measuring antioxidant enzyme and prostaglandin E2 levels in the gastric tissue of HCl/EtOH-treated rats. Oral administration of P. cuspidatum extract (PCE) at doses of 100 and 300 mg/kg significantly decreased HCl/EtOH- and indomethacin-induced gastric lesions. PCE at 300 mg/kg significantly reduced gastric lesions in acetic acid-induced ulcers. PCE increased superoxide dismutase (SOD)activity and glutathione(GSH) and prostaglandin E2 levels in gastric tissue, whereas it did not alter gastric acid secretion-related parameters. Our findings indicate that PCE has gastroprotective effects against HCl/EtOH and non-steroidal anti-inflammatory drugs(NSAIDs) and promotes healing of acetic acid-induced ulcers. These gastric mucosal protection and ulcer healing effects are associated with antioxidant effects and the augmentation of prostaglandin E2 and suggest that P. cuspidatum might be a promising preventive and therapeutic agent for treating gastric ulcers. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32727104/Gastroprotective_and_Healing_Effects_of_Polygonum_cuspidatum_Root_on_Experimentally_Induced_Gastric_Ulcers_in_Rats_ L2 - https://www.mdpi.com/resolver?pii=nu12082241 DB - PRIME DP - Unbound Medicine ER -