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Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study.
BMC Infect Dis. 2020 Jul 29; 20(1):549.BI

Abstract

BACKGROUND

We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China.

METHODS

Clinical data on COVID-19 inpatients in Zengdu Hospital from January 27 to March 11, 2020 were collected; this is a community hospital in an area surrounding Wuhan and supported by volunteer doctors. All hospitalized patients with COVID-19 were included in this study. The epidemiological findings, clinical features, laboratory findings, radiologic manifestations, and clinical outcomes of these patients were analyzed. The patients were followed up for clinical outcomes until March 22, 2020. Severe COVID-19 cases include severe and critical cases diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines. Severe and critical COVID-19 cases were diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines.

RESULTS

All hospitalized COVID-19 patients, 276 (median age: 51.0 years), were enrolled, including 262 non-severe and 14 severe patients. The proportion of patients aged over 60 years was higher in the severe group (78.6%) than in the non-severe group (18.7%, p < 0.01). Approximately a quarter of the patients (24.6%) had at least one comorbidity, such as hypertension, diabetes, or cancer, and the proportion of patients with comorbidities was higher in the severe group (85.7%) than in the non-severe group (21.4%, p < 0.01). Common symptoms included fever (82.2% [227/276]) and cough (78.0% [218/276]). 38.4% (106/276) of the patients had a fever at the time of admission. Most patients (94.9% [204/276]) were cured and discharged; 3.6% (10/276) deteriorated to a critical condition and were transferred to another hospital. The median COVID-19 treatment duration and hospital stay were 14.0 and 18.0 days, respectively.

CONCLUSIONS

Most of the COVID-19 patients in Zengdu had mild disease. Older patients with underlying diseases were at a higher risk of progression to severe disease. The length of hospital-stay and antiviral treatment duration for COVID-19 were slightly longer than those in Wuhan. This work will contribute toward an understanding of COVID-19 characteristics in the areas around the core COVID-19 outbreak region and serve as a reference for decision-making for epidemic prevention and control in similar areas.

Authors+Show Affiliations

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.Suizhou Zengdu Hospital, Suizhou, China.Department of Radiotherapy, Jiangxi Cancer Hospital, NanChang, China.Department of CT&MRI, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.Department of Respiratory Medicine, Chongyi County People's Hospital, Ganzhou, China.Department of Critical Medicine, Ganzhou Tumor Hospital, Ganzhou, China.Department of Critical Care Medicine, Dingnan People's Hospital, Dingnan, China.Department of Critical Medicine, Anyuan People's Hospital, Ganzhou, China.Department of Infectious Disease, Xingguo People's Hospital, Ganzhou, China.Department of Respiratory Medicine, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, China.Department of General Practice, The First People's Hospital of Fuzhou, Fuzhou, China.Department of Pediatric Neurology, Ganzhou Women's and Children's Hospital of Jiangxi Province, Ganzhou, China.Neurosurgery Department, The Second Affiliated Hospital of Nanchang University, Nanchang, China.Department of Respiratory Medicine, Ganzhou People's Hospital, No.17 Hongqi Avenue, Ganzhou City, 341000, Jiangxi Province, China. gzliujs@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32727456

Citation

Wei, Yiping, et al. "Clinical Characteristics of 276 Hospitalized Patients With Coronavirus Disease 2019 in Zengdu District, Hubei Province: a Single-center Descriptive Study." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 549.
Wei Y, Zeng W, Huang X, et al. Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study. BMC Infect Dis. 2020;20(1):549.
Wei, Y., Zeng, W., Huang, X., Li, J., Qiu, X., Li, H., Liu, D., He, Z., Yao, W., Huang, P., Li, C., Zhu, M., Zhong, C., Zhu, X., & Liu, J. (2020). Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study. BMC Infectious Diseases, 20(1), 549. https://doi.org/10.1186/s12879-020-05252-8
Wei Y, et al. Clinical Characteristics of 276 Hospitalized Patients With Coronavirus Disease 2019 in Zengdu District, Hubei Province: a Single-center Descriptive Study. BMC Infect Dis. 2020 Jul 29;20(1):549. PubMed PMID: 32727456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study. AU - Wei,Yiping, AU - Zeng,Weibiao, AU - Huang,Xiangyun, AU - Li,Junyu, AU - Qiu,Xingting, AU - Li,Huadong, AU - Liu,Dinghua, AU - He,Zhaofeng, AU - Yao,Wenzhong, AU - Huang,Ping, AU - Li,Chao, AU - Zhu,Min, AU - Zhong,Chunlan, AU - Zhu,Xingen, AU - Liu,Jiansheng, Y1 - 2020/07/29/ PY - 2020/05/02/received PY - 2020/07/14/accepted PY - 2020/7/31/entrez PY - 2020/7/31/pubmed PY - 2020/8/1/medline KW - COVID-19 KW - Clinical characteristics KW - Echocardiography KW - SARS-CoV-2 SP - 549 EP - 549 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 20 IS - 1 N2 - BACKGROUND: We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China. METHODS: Clinical data on COVID-19 inpatients in Zengdu Hospital from January 27 to March 11, 2020 were collected; this is a community hospital in an area surrounding Wuhan and supported by volunteer doctors. All hospitalized patients with COVID-19 were included in this study. The epidemiological findings, clinical features, laboratory findings, radiologic manifestations, and clinical outcomes of these patients were analyzed. The patients were followed up for clinical outcomes until March 22, 2020. Severe COVID-19 cases include severe and critical cases diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines. Severe and critical COVID-19 cases were diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines. RESULTS: All hospitalized COVID-19 patients, 276 (median age: 51.0 years), were enrolled, including 262 non-severe and 14 severe patients. The proportion of patients aged over 60 years was higher in the severe group (78.6%) than in the non-severe group (18.7%, p < 0.01). Approximately a quarter of the patients (24.6%) had at least one comorbidity, such as hypertension, diabetes, or cancer, and the proportion of patients with comorbidities was higher in the severe group (85.7%) than in the non-severe group (21.4%, p < 0.01). Common symptoms included fever (82.2% [227/276]) and cough (78.0% [218/276]). 38.4% (106/276) of the patients had a fever at the time of admission. Most patients (94.9% [204/276]) were cured and discharged; 3.6% (10/276) deteriorated to a critical condition and were transferred to another hospital. The median COVID-19 treatment duration and hospital stay were 14.0 and 18.0 days, respectively. CONCLUSIONS: Most of the COVID-19 patients in Zengdu had mild disease. Older patients with underlying diseases were at a higher risk of progression to severe disease. The length of hospital-stay and antiviral treatment duration for COVID-19 were slightly longer than those in Wuhan. This work will contribute toward an understanding of COVID-19 characteristics in the areas around the core COVID-19 outbreak region and serve as a reference for decision-making for epidemic prevention and control in similar areas. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/32727456/Clinical_characteristics_of_276_hospitalized_patients_with_coronavirus_disease_2019_in_Zengdu_District_Hubei_Province:_a_single_center_descriptive_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05252-8 DB - PRIME DP - Unbound Medicine ER -