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HLA-DR1 and HLA-DR3 phenotypes and insulin antibody production in diabetic Sicilian patients.
Exp Clin Immunogenet. 1988; 5(1):48-51.EC

Abstract

We have evaluated the role played by HLA antigens in the control of humoral response to exogenous insulin in a sample of Sicilian insulin-dependent diabetes mellitus patients. The results demonstrate that HLA-DR1-positive patients show the highest mean values of insulin antibody, whereas HLA-B18,DR3-positive patients show the lowest. Thus, present observations show that HLA-DR1- and HLA-DR3-linked genes do play opposite roles in the humoral immune response to an exogenous protein, i.e. injected insulin. These results might be consistent with the findings concerning the mechanisms involved in the resistance and/or susceptibility to immunological diseases. In this regard, the fact that no immunological spontaneous disorder has been shown to be associated with HLA-DR1, whereas several have been shown to be associated with HLA-DR3, is intriguing.

Authors+Show Affiliations

Istituti di Patologia generale, Università di Palermo, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3272815

Citation

Caruso, C, et al. "HLA-DR1 and HLA-DR3 Phenotypes and Insulin Antibody Production in Diabetic Sicilian Patients." Experimental and Clinical Immunogenetics, vol. 5, no. 1, 1988, pp. 48-51.
Caruso C, Giordano C, Galluzzo A, et al. HLA-DR1 and HLA-DR3 phenotypes and insulin antibody production in diabetic Sicilian patients. Exp Clin Immunogenet. 1988;5(1):48-51.
Caruso, C., Giordano, C., Galluzzo, A., Pantò, F., & Modica, M. A. (1988). HLA-DR1 and HLA-DR3 phenotypes and insulin antibody production in diabetic Sicilian patients. Experimental and Clinical Immunogenetics, 5(1), 48-51.
Caruso C, et al. HLA-DR1 and HLA-DR3 Phenotypes and Insulin Antibody Production in Diabetic Sicilian Patients. Exp Clin Immunogenet. 1988;5(1):48-51. PubMed PMID: 3272815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DR1 and HLA-DR3 phenotypes and insulin antibody production in diabetic Sicilian patients. AU - Caruso,C, AU - Giordano,C, AU - Galluzzo,A, AU - Pantò,F, AU - Modica,M A, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 48 EP - 51 JF - Experimental and clinical immunogenetics JO - Exp Clin Immunogenet VL - 5 IS - 1 N2 - We have evaluated the role played by HLA antigens in the control of humoral response to exogenous insulin in a sample of Sicilian insulin-dependent diabetes mellitus patients. The results demonstrate that HLA-DR1-positive patients show the highest mean values of insulin antibody, whereas HLA-B18,DR3-positive patients show the lowest. Thus, present observations show that HLA-DR1- and HLA-DR3-linked genes do play opposite roles in the humoral immune response to an exogenous protein, i.e. injected insulin. These results might be consistent with the findings concerning the mechanisms involved in the resistance and/or susceptibility to immunological diseases. In this regard, the fact that no immunological spontaneous disorder has been shown to be associated with HLA-DR1, whereas several have been shown to be associated with HLA-DR3, is intriguing. SN - 0254-9670 UR - https://www.unboundmedicine.com/medline/citation/3272815/HLA_DR1_and_HLA_DR3_phenotypes_and_insulin_antibody_production_in_diabetic_Sicilian_patients_ L2 - https://medlineplus.gov/diabetestype1.html DB - PRIME DP - Unbound Medicine ER -