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Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.
Emerg Infect Dis. 2020 12; 26(12):2961-2965.EI

Abstract

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32730733

Citation

Lau, Susanna K P., et al. "Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells." Emerging Infectious Diseases, vol. 26, no. 12, 2020, pp. 2961-2965.
Lau SKP, Wong ACP, Luk HKH, et al. Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells. Emerg Infect Dis. 2020;26(12):2961-2965.
Lau, S. K. P., Wong, A. C. P., Luk, H. K. H., Li, K. S. M., Fung, J., He, Z., Cheng, F. K. K., Chan, T. T. Y., Chu, S., Aw-Yong, K. L., Lau, T. C. K., Fung, K. S. C., & Woo, P. C. Y. (2020). Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells. Emerging Infectious Diseases, 26(12), 2961-2965. https://doi.org/10.3201/eid2612.202308
Lau SKP, et al. Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells. Emerg Infect Dis. 2020;26(12):2961-2965. PubMed PMID: 32730733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells. AU - Lau,Susanna K P, AU - Wong,Antonio C P, AU - Luk,Hayes K H, AU - Li,Kenneth S M, AU - Fung,Joshua, AU - He,Zirong, AU - Cheng,Flora K K, AU - Chan,Tony T Y, AU - Chu,Stella, AU - Aw-Yong,Kam Leng, AU - Lau,Terrence C K, AU - Fung,Kitty S C, AU - Woo,Patrick C Y, Y1 - 2020/07/30/ PY - 2020/7/31/pubmed PY - 2021/1/2/medline PY - 2020/7/31/entrez KW - COVID-19 KW - SARS KW - SARS-CoV-2 KW - SARS-related coronavirus KW - bat KW - coronavirus disease KW - origin KW - respiratory infections KW - severe acute respiratory syndrome KW - severe acute respiratory syndrome coronavirus 2 KW - tropism KW - viruses KW - zoonoses SP - 2961 EP - 2965 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 26 IS - 12 N2 - Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/32730733/Differential_Tropism_of_SARS_CoV_and_SARS_CoV_2_in_Bat_Cells_ L2 - https://doi.org/10.3201/eid2612.202308 DB - PRIME DP - Unbound Medicine ER -