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Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
Pharmacol Res. 2020 11; 161:105098.PR

Abstract

BACKGROUND

We aimed to investigate the effect of chromium supplementation on glycemic control indices in patients with type 2 diabetes (T2DM).

METHODS

Randomized controlled trials examining the effect of chromium supplementation on glycemic control indices and published before February 2020 were detected by searching online databases, including PubMed, Scopus, Embase, Web of sciences and The Cochrane Library, using a combination of suitable keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the supplementation group and the control group at follow-up.

RESULTS

Twenty-eight studies reported fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C) and homeostatic model assessment for insulin resistance (HOMA-IR) as an outcome measure. Results revealed significant reduction in FPG (weighted mean difference (WMD): -19.00 mg/dl, 95% CI: -36.15, -1.85, P = 0.030; I2: 99.8%, p < 0.001), insulin level (WMD: -12.35 pmol/l, 95% CI: -17.86, -6.83, P < 0.001), HbA1C (WMD: -0.71 %, 95% CI: -1.19, -0.23, P = 0.004) and HOMA-IR (WMD: -1.53, 95% CI: -2.35, -0.72, P < 0.001; I2: 89.9%, p < 0.001) after chromium supplementation.

CONCLUSION

The results of the current meta-analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients.

Authors+Show Affiliations

Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: omid.asbaghi@gmail.com.Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science, Tehran, Iran. Electronic address: dr.fnaeeni@gmail.com.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: m.rezaei81@yahoo.com.Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: ehsanghaedi073@gmail.com.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: islampoor.eli@gmail.com.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: nazarianbehzad969@yahoo.com.Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Damoon_ashtary@yahoo.com.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: am.alavi@nutr.mui.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32730903

Citation

Asbaghi, Omid, et al. "Effects of Chromium Supplementation On Glycemic Control in Patients With Type 2 Diabetes: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Pharmacological Research, vol. 161, 2020, p. 105098.
Asbaghi O, Fatemeh N, Mahnaz RK, et al. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2020;161:105098.
Asbaghi, O., Fatemeh, N., Mahnaz, R. K., Ehsan, G., Elham, E., Behzad, N., Damoon, A. L., & Amirmansour, A. N. (2020). Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 161, 105098. https://doi.org/10.1016/j.phrs.2020.105098
Asbaghi O, et al. Effects of Chromium Supplementation On Glycemic Control in Patients With Type 2 Diabetes: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Pharmacol Res. 2020;161:105098. PubMed PMID: 32730903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. AU - Asbaghi,Omid, AU - Fatemeh,Naeini, AU - Mahnaz,Rezaei Kelishadi, AU - Ehsan,Ghaedi, AU - Elham,Eslampour, AU - Behzad,Nazarian, AU - Damoon,Ashtary-Larky, AU - Amirmansour,Alavi Naeini, Y1 - 2020/07/28/ PY - 2020/04/02/received PY - 2020/07/21/revised PY - 2020/07/22/accepted PY - 2020/7/31/pubmed PY - 2021/9/2/medline PY - 2020/7/31/entrez KW - chromium KW - clinical trials KW - diabetes KW - glycemic control KW - meta-analysis SP - 105098 EP - 105098 JF - Pharmacological research JO - Pharmacol Res VL - 161 N2 - BACKGROUND: We aimed to investigate the effect of chromium supplementation on glycemic control indices in patients with type 2 diabetes (T2DM). METHODS: Randomized controlled trials examining the effect of chromium supplementation on glycemic control indices and published before February 2020 were detected by searching online databases, including PubMed, Scopus, Embase, Web of sciences and The Cochrane Library, using a combination of suitable keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the supplementation group and the control group at follow-up. RESULTS: Twenty-eight studies reported fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C) and homeostatic model assessment for insulin resistance (HOMA-IR) as an outcome measure. Results revealed significant reduction in FPG (weighted mean difference (WMD): -19.00 mg/dl, 95% CI: -36.15, -1.85, P = 0.030; I2: 99.8%, p < 0.001), insulin level (WMD: -12.35 pmol/l, 95% CI: -17.86, -6.83, P < 0.001), HbA1C (WMD: -0.71 %, 95% CI: -1.19, -0.23, P = 0.004) and HOMA-IR (WMD: -1.53, 95% CI: -2.35, -0.72, P < 0.001; I2: 89.9%, p < 0.001) after chromium supplementation. CONCLUSION: The results of the current meta-analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/32730903/Effects_of_chromium_supplementation_on_glycemic_control_in_patients_with_type_2_diabetes:_a_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(20)31406-7 DB - PRIME DP - Unbound Medicine ER -