Citation
Mercado, Noe B., et al. "Single-shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques." Nature, vol. 586, no. 7830, 2020, pp. 583-588.
Mercado NB, Zahn R, Wegmann F, et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020;586(7830):583-588.
Mercado, N. B., Zahn, R., Wegmann, F., Loos, C., Chandrashekar, A., Yu, J., Liu, J., Peter, L., McMahan, K., Tostanoski, L. H., He, X., Martinez, D. R., Rutten, L., Bos, R., van Manen, D., Vellinga, J., Custers, J., Langedijk, J. P., Kwaks, T., ... Barouch, D. H. (2020). Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature, 586(7830), 583-588. https://doi.org/10.1038/s41586-020-2607-z
Mercado NB, et al. Single-shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques. Nature. 2020;586(7830):583-588. PubMed PMID: 32731257.
TY - JOUR
T1 - Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
AU - Mercado,Noe B,
AU - Zahn,Roland,
AU - Wegmann,Frank,
AU - Loos,Carolin,
AU - Chandrashekar,Abishek,
AU - Yu,Jingyou,
AU - Liu,Jinyan,
AU - Peter,Lauren,
AU - McMahan,Katherine,
AU - Tostanoski,Lisa H,
AU - He,Xuan,
AU - Martinez,David R,
AU - Rutten,Lucy,
AU - Bos,Rinke,
AU - van Manen,Danielle,
AU - Vellinga,Jort,
AU - Custers,Jerome,
AU - Langedijk,Johannes P,
AU - Kwaks,Ted,
AU - Bakkers,Mark J G,
AU - Zuijdgeest,David,
AU - Rosendahl Huber,Sietske K,
AU - Atyeo,Caroline,
AU - Fischinger,Stephanie,
AU - Burke,John S,
AU - Feldman,Jared,
AU - Hauser,Blake M,
AU - Caradonna,Timothy M,
AU - Bondzie,Esther A,
AU - Dagotto,Gabriel,
AU - Gebre,Makda S,
AU - Hoffman,Emily,
AU - Jacob-Dolan,Catherine,
AU - Kirilova,Marinela,
AU - Li,Zhenfeng,
AU - Lin,Zijin,
AU - Mahrokhian,Shant H,
AU - Maxfield,Lori F,
AU - Nampanya,Felix,
AU - Nityanandam,Ramya,
AU - Nkolola,Joseph P,
AU - Patel,Shivani,
AU - Ventura,John D,
AU - Verrington,Kaylee,
AU - Wan,Huahua,
AU - Pessaint,Laurent,
AU - Van Ry,Alex,
AU - Blade,Kelvin,
AU - Strasbaugh,Amanda,
AU - Cabus,Mehtap,
AU - Brown,Renita,
AU - Cook,Anthony,
AU - Zouantchangadou,Serge,
AU - Teow,Elyse,
AU - Andersen,Hanne,
AU - Lewis,Mark G,
AU - Cai,Yongfei,
AU - Chen,Bing,
AU - Schmidt,Aaron G,
AU - Reeves,R Keith,
AU - Baric,Ralph S,
AU - Lauffenburger,Douglas A,
AU - Alter,Galit,
AU - Stoffels,Paul,
AU - Mammen,Mathai,
AU - Van Hoof,Johan,
AU - Schuitemaker,Hanneke,
AU - Barouch,Dan H,
Y1 - 2020/07/30/
PY - 2020/6/20/received
PY - 2020/7/24/accepted
PY - 2020/7/31/pubmed
PY - 2020/10/30/medline
PY - 2020/7/31/entrez
SP - 583
EP - 588
JF - Nature
JO - Nature
VL - 586
IS - 7830
N2 - A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1-8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/32731257/Single_shot_Ad26_vaccine_protects_against_SARS_CoV_2_in_rhesus_macaques_
DB - PRIME
DP - Unbound Medicine
ER -