Citation
van Doremalen, Neeltje, et al. "ChAdOx1 nCoV-19 Vaccine Prevents SARS-CoV-2 Pneumonia in Rhesus Macaques." Nature, vol. 586, no. 7830, 2020, pp. 578-582.
van Doremalen N, Lambe T, Spencer A, et al. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques. Nature. 2020;586(7830):578-582.
van Doremalen, N., Lambe, T., Spencer, A., Belij-Rammerstorfer, S., Purushotham, J. N., Port, J. R., Avanzato, V. A., Bushmaker, T., Flaxman, A., Ulaszewska, M., Feldmann, F., Allen, E. R., Sharpe, H., Schulz, J., Holbrook, M., Okumura, A., Meade-White, K., Pérez-Pérez, L., Edwards, N. J., ... Munster, V. J. (2020). ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques. Nature, 586(7830), 578-582. https://doi.org/10.1038/s41586-020-2608-y
van Doremalen N, et al. ChAdOx1 nCoV-19 Vaccine Prevents SARS-CoV-2 Pneumonia in Rhesus Macaques. Nature. 2020;586(7830):578-582. PubMed PMID: 32731258.
TY - JOUR
T1 - ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques.
AU - van Doremalen,Neeltje,
AU - Lambe,Teresa,
AU - Spencer,Alexandra,
AU - Belij-Rammerstorfer,Sandra,
AU - Purushotham,Jyothi N,
AU - Port,Julia R,
AU - Avanzato,Victoria A,
AU - Bushmaker,Trenton,
AU - Flaxman,Amy,
AU - Ulaszewska,Marta,
AU - Feldmann,Friederike,
AU - Allen,Elizabeth R,
AU - Sharpe,Hannah,
AU - Schulz,Jonathan,
AU - Holbrook,Myndi,
AU - Okumura,Atsushi,
AU - Meade-White,Kimberly,
AU - Pérez-Pérez,Lizzette,
AU - Edwards,Nick J,
AU - Wright,Daniel,
AU - Bissett,Cameron,
AU - Gilbride,Ciaran,
AU - Williamson,Brandi N,
AU - Rosenke,Rebecca,
AU - Long,Dan,
AU - Ishwarbhai,Alka,
AU - Kailath,Reshma,
AU - Rose,Louisa,
AU - Morris,Susan,
AU - Powers,Claire,
AU - Lovaglio,Jamie,
AU - Hanley,Patrick W,
AU - Scott,Dana,
AU - Saturday,Greg,
AU - de Wit,Emmie,
AU - Gilbert,Sarah C,
AU - Munster,Vincent J,
Y1 - 2020/07/30/
PY - 2020/05/13/received
PY - 2020/07/24/accepted
PY - 2020/7/31/pubmed
PY - 2020/10/30/medline
PY - 2020/7/31/entrez
SP - 578
EP - 582
JF - Nature
JO - Nature
VL - 586
IS - 7830
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the coronavirus disease 2019 (COVID-19) pandemic3. Vaccines are an essential countermeasure and are urgently needed to control the pandemic4. Here we show that the adenovirus-vector-based vaccine ChAdOx1 nCoV-19, which encodes the spike protein of SARS-CoV-2, is immunogenic in mice and elicites a robust humoral and cell-mediated response. This response was predominantly mediated by type-1 T helper cells, as demonstrated by the profiling of the IgG subclass and the expression of cytokines. Vaccination with ChAdOx1 nCoV-19 (using either a prime-only or a prime-boost regimen) induced a balanced humoral and cellular immune response of type-1 and type-2 T helper cells in rhesus macaques. We observed a significantly reduced viral load in the bronchoalveolar lavage fluid and lower respiratory tract tissue of vaccinated rhesus macaques that were challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in vaccinated SARS-CoV-2-infected animals. However, there was no difference in nasal shedding between vaccinated and control SARS-CoV-2-infected macaques. Notably, we found no evidence of immune-enhanced disease after viral challenge in vaccinated SARS-CoV-2-infected animals. The safety, immunogenicity and efficacy profiles of ChAdOx1 nCoV-19 against symptomatic PCR-positive COVID-19 disease will now be assessed in randomized controlled clinical trials in humans.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/32731258/ChAdOx1_nCoV_19_vaccine_prevents_SARS_CoV_2_pneumonia_in_rhesus_macaques_
DB - PRIME
DP - Unbound Medicine
ER -