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Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment.
BMB Rep. 2020 Aug; 53(8):400-412.BR

Abstract

The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. [BMB Reports 2020; 53(8): 400-412].

Authors+Show Affiliations

Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046; Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India.Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India.SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya campus, Chennai 600-006, India.Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046, India.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046, India.Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32731913

Citation

Jayaramayya, Kaavya, et al. "Immunomodulatory Effect of Mesenchymal Stem Cells and Mesenchymal Stem-cell-derived Exosomes for COVID-19 Treatment." BMB Reports, vol. 53, no. 8, 2020, pp. 400-412.
Jayaramayya K, Mahalaxmi I, Subramaniam MD, et al. Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment. BMB Rep. 2020;53(8):400-412.
Jayaramayya, K., Mahalaxmi, I., Subramaniam, M. D., Raj, N., Dayem, A. A., Lim, K. M., Kim, S. J., An, J. Y., Lee, Y., Choi, Y., Raj, A., Cho, S. G., & Vellingiri, B. (2020). Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment. BMB Reports, 53(8), 400-412.
Jayaramayya K, et al. Immunomodulatory Effect of Mesenchymal Stem Cells and Mesenchymal Stem-cell-derived Exosomes for COVID-19 Treatment. BMB Rep. 2020;53(8):400-412. PubMed PMID: 32731913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment. AU - Jayaramayya,Kaavya, AU - Mahalaxmi,Iyer, AU - Subramaniam,Mohana Devi, AU - Raj,Neethu, AU - Dayem,Ahmed Abdal, AU - Lim,Kyung Min, AU - Kim,Se Jong, AU - An,Jong Yub, AU - Lee,Yoonjoo, AU - Choi,Yujin, AU - Raj,Arthi, AU - Cho,Ssang-Goo, AU - Vellingiri,Balachandar, PY - 2020/06/05/received PY - 2020/8/1/pubmed PY - 2020/9/4/medline PY - 2020/8/1/entrez SP - 400 EP - 412 JF - BMB reports JO - BMB Rep VL - 53 IS - 8 N2 - The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. [BMB Reports 2020; 53(8): 400-412]. SN - 1976-670X UR - https://www.unboundmedicine.com/medline/citation/32731913/Immunomodulatory_effect_of_mesenchymal_stem_cells_and_mesenchymal_stem_cell_derived_exosomes_for_COVID_19_treatment_ DB - PRIME DP - Unbound Medicine ER -