Tags

Type your tag names separated by a space and hit enter

Gonadotropic responsiveness to clomiphene, LRH, estradiol, and bromocriptine in galactorrheic women.
Obstet Gynecol. 1977 Aug; 50(2):139-44.OG

Abstract

Twenty hyperprolactinemic patients with galactorrhea were studied to determine their gonadotropic responses to various stimuli. Five women lacked response to gonadotropin following the administration of clomiphene citrate. Ten patients who had luteinizing hormone releasing hormone (LRH) tests before and during bromocriptine administration exhibited varied FSH and LH responses that apparently were unaffected by bromocriptine therapy. A loss of the normal positive feedback of estrogens at the level of the hypothalamus was demonstrated in most patients before and during bromocriptine therapy. Long-term treatment with bromocriptine in 11 women resulted in a decrease of serum prolactin, cessation of lactation in all, and pregnancy in 8. These results suggest that the failure of normal secretion of gonadotropins in hyperprolactinemic women may result from 1) inadequate release of endogenous LRH, and 2) loss of the positive feedback of estrogens, as a result of the same hypothalamic disturbance that provokes the hyperprolactinemia. In turn, the elevated prolactin levels may exert a short-loop negative feedback at the hypothalamic level, inhibiting cyclic gonadotropin release.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

327363

Citation

Forsbach, G, et al. "Gonadotropic Responsiveness to Clomiphene, LRH, Estradiol, and Bromocriptine in Galactorrheic Women." Obstetrics and Gynecology, vol. 50, no. 2, 1977, pp. 139-44.
Forsbach G, Soria J, Canales ES, et al. Gonadotropic responsiveness to clomiphene, LRH, estradiol, and bromocriptine in galactorrheic women. Obstet Gynecol. 1977;50(2):139-44.
Forsbach, G., Soria, J., Canales, E. S., Guzman, V., Cabezas, A., & Zárate, A. (1977). Gonadotropic responsiveness to clomiphene, LRH, estradiol, and bromocriptine in galactorrheic women. Obstetrics and Gynecology, 50(2), 139-44.
Forsbach G, et al. Gonadotropic Responsiveness to Clomiphene, LRH, Estradiol, and Bromocriptine in Galactorrheic Women. Obstet Gynecol. 1977;50(2):139-44. PubMed PMID: 327363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gonadotropic responsiveness to clomiphene, LRH, estradiol, and bromocriptine in galactorrheic women. AU - Forsbach,G, AU - Soria,J, AU - Canales,E S, AU - Guzman,V, AU - Cabezas,A, AU - Zárate,A, PY - 1977/8/1/pubmed PY - 1977/8/1/medline PY - 1977/8/1/entrez SP - 139 EP - 44 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 50 IS - 2 N2 - Twenty hyperprolactinemic patients with galactorrhea were studied to determine their gonadotropic responses to various stimuli. Five women lacked response to gonadotropin following the administration of clomiphene citrate. Ten patients who had luteinizing hormone releasing hormone (LRH) tests before and during bromocriptine administration exhibited varied FSH and LH responses that apparently were unaffected by bromocriptine therapy. A loss of the normal positive feedback of estrogens at the level of the hypothalamus was demonstrated in most patients before and during bromocriptine therapy. Long-term treatment with bromocriptine in 11 women resulted in a decrease of serum prolactin, cessation of lactation in all, and pregnancy in 8. These results suggest that the failure of normal secretion of gonadotropins in hyperprolactinemic women may result from 1) inadequate release of endogenous LRH, and 2) loss of the positive feedback of estrogens, as a result of the same hypothalamic disturbance that provokes the hyperprolactinemia. In turn, the elevated prolactin levels may exert a short-loop negative feedback at the hypothalamic level, inhibiting cyclic gonadotropin release. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/327363/Gonadotropic_responsiveness_to_clomiphene_LRH_estradiol_and_bromocriptine_in_galactorrheic_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=327363.ui DB - PRIME DP - Unbound Medicine ER -