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MicroRNA and long noncoding RNA involvement in gout and prospects for treatment.
Int Immunopharmacol. 2020 Oct; 87:106842.II

Abstract

MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Recent studies have shown that miRNAs and lncRNAs mediate the progress of gout. Based on the pathogenesis of gout, including hyperuricemia, MSU deposition, acute gouty arthritis and gouty bone erosion, this paper reviewed the role of miRNAs and lncRNAs in the processes and the possible therapeutic targets of miRNAs and lncRNAs in gout.

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Authors+Show Affiliations

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China. Electronic address: xiayz@cpu.edu.cn.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China. Electronic address: cpu_lykong@126.com.

MeSH

AnimalsGoutHumansMicroRNAsRNA, Long Noncoding

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32738598

Citation

Xu, Yi-Ting, et al. "MicroRNA and Long Noncoding RNA Involvement in Gout and Prospects for Treatment." International Immunopharmacology, vol. 87, 2020, p. 106842.

Xu YT, Leng YR, Liu MM, et al. MicroRNA and long noncoding RNA involvement in gout and prospects for treatment. Int Immunopharmacol. 2020;87:106842.

Xu, Y. T., Leng, Y. R., Liu, M. M., Dong, R. F., Bian, J., Yuan, L. L., Zhang, J. G., Xia, Y. Z., & Kong, L. Y. (2020). MicroRNA and long noncoding RNA involvement in gout and prospects for treatment. International Immunopharmacology, 87, 106842. https://doi.org/10.1016/j.intimp.2020.106842

Xu YT, et al. MicroRNA and Long Noncoding RNA Involvement in Gout and Prospects for Treatment. Int Immunopharmacol. 2020;87:106842. PubMed PMID: 32738598.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - MicroRNA and long noncoding RNA involvement in gout and prospects for treatment. AU - Xu,Yi-Ting, AU - Leng,Ying-Rong, AU - Liu,Ming-Ming, AU - Dong,Rui-Fang, AU - Bian,Jing, AU - Yuan,Liu-Liu, AU - Zhang,Jian-Guo, AU - Xia,Yuan-Zheng, AU - Kong,Ling-Yi, Y1 - 2020/07/29/ PY - 2020/06/03/received PY - 2020/07/19/revised PY - 2020/07/23/accepted PY - 2020/8/2/pubmed PY - 2021/5/28/medline PY - 2020/8/2/entrez KW - Acute arthritis KW - Bone erosion KW - Hyperuricemia KW - LncRNA KW - MSU KW - MiRNA SP - 106842 EP - 106842 JF - International immunopharmacology JO - Int Immunopharmacol VL - 87 N2 - MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Recent studies have shown that miRNAs and lncRNAs mediate the progress of gout. Based on the pathogenesis of gout, including hyperuricemia, MSU deposition, acute gouty arthritis and gouty bone erosion, this paper reviewed the role of miRNAs and lncRNAs in the processes and the possible therapeutic targets of miRNAs and lncRNAs in gout. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/32738598/MicroRNA_and_long_noncoding_RNA_involvement_in_gout_and_prospects_for_treatment_ DB - PRIME DP - Unbound Medicine ER -