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COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials.
Biochem Pharmacol. 2020 10; 180:114184.BP

Abstract

COVID-19, the greatest public health emergency of the 21st century, has affected 215 countries and territories around the world resulting in 15,151,738 confirmed cases and 621,121 deaths. The outbreak has continued at breakneck pace despite stringent public health measures, ravaging the global economy and causing profound human casualties. Vaccination is currently the best bet for the prevention of COVID-19. Still, in its absence, there has been considerable interest in repurposing existing therapeutic agents to reduce the severity of the illness and ease the burden on the already strained healthcare systems. This review outlines the current evidence regarding proposed treatments- experimental or repurposed, for COVID-19, and gives an insight into the clinical trial landscape for drugs as well as vaccines.

Authors+Show Affiliations

Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India. Electronic address: sparvez@jamiahamdard.ac.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32739342

Citation

Chakraborty, Rohan, and Suhel Parvez. "COVID-19: an Overview of the Current Pharmacological Interventions, Vaccines, and Clinical Trials." Biochemical Pharmacology, vol. 180, 2020, p. 114184.
Chakraborty R, Parvez S. COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials. Biochem Pharmacol. 2020;180:114184.
Chakraborty, R., & Parvez, S. (2020). COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials. Biochemical Pharmacology, 180, 114184. https://doi.org/10.1016/j.bcp.2020.114184
Chakraborty R, Parvez S. COVID-19: an Overview of the Current Pharmacological Interventions, Vaccines, and Clinical Trials. Biochem Pharmacol. 2020;180:114184. PubMed PMID: 32739342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials. AU - Chakraborty,Rohan, AU - Parvez,Suhel, Y1 - 2020/07/30/ PY - 2020/06/24/received PY - 2020/07/24/revised PY - 2020/07/27/accepted PY - 2020/8/3/pubmed PY - 2020/11/18/medline PY - 2020/8/3/entrez KW - COVID-19 KW - Clinical trials KW - Coronavirus KW - Drugs KW - SARS-CoV-2 KW - Vaccines SP - 114184 EP - 114184 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 180 N2 - COVID-19, the greatest public health emergency of the 21st century, has affected 215 countries and territories around the world resulting in 15,151,738 confirmed cases and 621,121 deaths. The outbreak has continued at breakneck pace despite stringent public health measures, ravaging the global economy and causing profound human casualties. Vaccination is currently the best bet for the prevention of COVID-19. Still, in its absence, there has been considerable interest in repurposing existing therapeutic agents to reduce the severity of the illness and ease the burden on the already strained healthcare systems. This review outlines the current evidence regarding proposed treatments- experimental or repurposed, for COVID-19, and gives an insight into the clinical trial landscape for drugs as well as vaccines. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/32739342/COVID_19:_An_overview_of_the_current_pharmacological_interventions_vaccines_and_clinical_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(20)30420-2 DB - PRIME DP - Unbound Medicine ER -