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Twin-screw melt granulation: Current progress and challenges.
Int J Pharm. 2020 Oct 15; 588:119670.IJ

Abstract

Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with more consistent quality than the batch process. Several studies have investigated how various formulation and processing parameters influence granulation behavior and granule properties; however, there are still challenges that require a better mechanistic understanding. This review summarizes the current progress of TSMG while highlighting how various formulation and process parameters affect the physicochemical properties of granules. The challenges related to the process-induced physicochemical changes of drug substances are also discussed.

Authors+Show Affiliations

Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409, University Avenue, Austin, TX 78712, United States.Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409, University Avenue, Austin, TX 78712, United States.Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409, University Avenue, Austin, TX 78712, United States. Electronic address: feng.zhang@austin.utexas.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32739382

Citation

Kittikunakorn, Nada, et al. "Twin-screw Melt Granulation: Current Progress and Challenges." International Journal of Pharmaceutics, vol. 588, 2020, p. 119670.
Kittikunakorn N, Liu T, Zhang F. Twin-screw melt granulation: Current progress and challenges. Int J Pharm. 2020;588:119670.
Kittikunakorn, N., Liu, T., & Zhang, F. (2020). Twin-screw melt granulation: Current progress and challenges. International Journal of Pharmaceutics, 588, 119670. https://doi.org/10.1016/j.ijpharm.2020.119670
Kittikunakorn N, Liu T, Zhang F. Twin-screw Melt Granulation: Current Progress and Challenges. Int J Pharm. 2020 Oct 15;588:119670. PubMed PMID: 32739382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Twin-screw melt granulation: Current progress and challenges. AU - Kittikunakorn,Nada, AU - Liu,Tongzhou, AU - Zhang,Feng, Y1 - 2020/07/30/ PY - 2020/05/28/received PY - 2020/07/03/revised PY - 2020/07/15/accepted PY - 2020/8/3/pubmed PY - 2021/2/18/medline PY - 2020/8/3/entrez KW - Continuous manufacturing KW - Melt granulation KW - Twin-screw melt granulation SP - 119670 EP - 119670 JF - International journal of pharmaceutics JO - Int J Pharm VL - 588 N2 - Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with more consistent quality than the batch process. Several studies have investigated how various formulation and processing parameters influence granulation behavior and granule properties; however, there are still challenges that require a better mechanistic understanding. This review summarizes the current progress of TSMG while highlighting how various formulation and process parameters affect the physicochemical properties of granules. The challenges related to the process-induced physicochemical changes of drug substances are also discussed. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/32739382/Twin_screw_melt_granulation:_Current_progress_and_challenges_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(20)30654-2 DB - PRIME DP - Unbound Medicine ER -