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Antimicrobial proanthocyanidin-chitosan composite nanoparticles loaded with gentamicin.
Int J Biol Macromol. 2020 Jul 30; 162:1500-1508.IJ

Abstract

Cranberry proanthocyanidin-chitosan nanoparticles (PAC-CHT NPs) loaded with antibiotic gentamicin (GEN) (PAC-CHT-GEN NPs) were formulated and characterized according to size, polydispersity (PDI), surface charge, morphology, and encapsulation efficiency (EE). PAC-CHT-GEN NPs were evaluated for their ability to agglutinate E. coli, S. aureus, and P. aeruginosa and their bacteriostatic and bactericidal activity. Results indicate that the PAC-CHT-GEN NPs at 0.5:1.0, 1.0:1.0, and 2.0:1.0 weight ratios formed stable nanoparticles with sizes from 242.9 to 277.4 nm, a PDI from 0.344 to 0.391, and a zeta potential from 34.5 to 38.5 mV, and up to 94% EE. Results indicate that PAC-CHT-GEN NPs have the ability to agglutinate E. coli, S. aureus, and P. aeruginosa. Furthermore, PAC-CHT-GEN NPs exhibited greater bactericidal activity than GEN alone. Results suggested PAC-CHT-GEN NPs form stable, round-shaped, and bioactive nanoparticles with the potential to be use in the treatment of bacterial infections.

Authors+Show Affiliations

Material Sciences & Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, United States; Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States. Electronic address: alfaroviquez@wisc.edu.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Material Sciences & Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, United States; Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32739510

Citation

Alfaro-Viquez, Emilia, et al. "Antimicrobial Proanthocyanidin-chitosan Composite Nanoparticles Loaded With Gentamicin." International Journal of Biological Macromolecules, vol. 162, 2020, pp. 1500-1508.
Alfaro-Viquez E, Esquivel-Alvarado D, Madrigal-Carballo S, et al. Antimicrobial proanthocyanidin-chitosan composite nanoparticles loaded with gentamicin. Int J Biol Macromol. 2020;162:1500-1508.
Alfaro-Viquez, E., Esquivel-Alvarado, D., Madrigal-Carballo, S., Krueger, C. G., & Reed, J. D. (2020). Antimicrobial proanthocyanidin-chitosan composite nanoparticles loaded with gentamicin. International Journal of Biological Macromolecules, 162, 1500-1508. https://doi.org/10.1016/j.ijbiomac.2020.07.213
Alfaro-Viquez E, et al. Antimicrobial Proanthocyanidin-chitosan Composite Nanoparticles Loaded With Gentamicin. Int J Biol Macromol. 2020 Jul 30;162:1500-1508. PubMed PMID: 32739510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial proanthocyanidin-chitosan composite nanoparticles loaded with gentamicin. AU - Alfaro-Viquez,Emilia, AU - Esquivel-Alvarado,Daniel, AU - Madrigal-Carballo,Sergio, AU - Krueger,Christian G, AU - Reed,Jess D, Y1 - 2020/07/30/ PY - 2020/03/04/received PY - 2020/06/14/revised PY - 2020/07/26/accepted PY - 2020/8/3/pubmed PY - 2020/8/3/medline PY - 2020/8/3/entrez KW - Bacterial agglutination KW - Bacteriostatic and bactericidal activity KW - Chitosan KW - Gentamicin KW - Proanthocyanidin SP - 1500 EP - 1508 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 162 N2 - Cranberry proanthocyanidin-chitosan nanoparticles (PAC-CHT NPs) loaded with antibiotic gentamicin (GEN) (PAC-CHT-GEN NPs) were formulated and characterized according to size, polydispersity (PDI), surface charge, morphology, and encapsulation efficiency (EE). PAC-CHT-GEN NPs were evaluated for their ability to agglutinate E. coli, S. aureus, and P. aeruginosa and their bacteriostatic and bactericidal activity. Results indicate that the PAC-CHT-GEN NPs at 0.5:1.0, 1.0:1.0, and 2.0:1.0 weight ratios formed stable nanoparticles with sizes from 242.9 to 277.4 nm, a PDI from 0.344 to 0.391, and a zeta potential from 34.5 to 38.5 mV, and up to 94% EE. Results indicate that PAC-CHT-GEN NPs have the ability to agglutinate E. coli, S. aureus, and P. aeruginosa. Furthermore, PAC-CHT-GEN NPs exhibited greater bactericidal activity than GEN alone. Results suggested PAC-CHT-GEN NPs form stable, round-shaped, and bioactive nanoparticles with the potential to be use in the treatment of bacterial infections. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/32739510/Antimicrobial_proanthocyanidin_chitosan_composite_nanoparticles_loaded_with_gentamicin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(20)33973-8 DB - PRIME DP - Unbound Medicine ER -
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