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Detection of COVID-19: A review of the current literature and future perspectives.
Biosens Bioelectron. 2020 Oct 15; 166:112455.BB

Abstract

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic.

Authors+Show Affiliations

Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China. Electronic address: jitianxing7021@163.com.Guangzhou Institute of Respiratory Medicine Company Limited, Guangzhou, 510535, PR China.Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, PR China.Laboratory of Pathology, Department of Pathobiology, University of Poonch Rawalakot, Rawala Kot, 12350, Pakistan.Department of Clinical Laboratory, Maoming People's Hospital, Maoming, 525000, PR China.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, HongKong, PR China. Electronic address: yangchaochen@cuhk.edu.hk.Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China. Electronic address: qiangzhou70@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32739797

Citation

Ji, Tianxing, et al. "Detection of COVID-19: a Review of the Current Literature and Future Perspectives." Biosensors & Bioelectronics, vol. 166, 2020, p. 112455.
Ji T, Liu Z, Wang G, et al. Detection of COVID-19: A review of the current literature and future perspectives. Biosens Bioelectron. 2020;166:112455.
Ji, T., Liu, Z., Wang, G., Guo, X., Akbar Khan, S., Lai, C., Chen, H., Huang, S., Xia, S., Chen, B., Jia, H., Chen, Y., & Zhou, Q. (2020). Detection of COVID-19: A review of the current literature and future perspectives. Biosensors & Bioelectronics, 166, 112455. https://doi.org/10.1016/j.bios.2020.112455
Ji T, et al. Detection of COVID-19: a Review of the Current Literature and Future Perspectives. Biosens Bioelectron. 2020 Oct 15;166:112455. PubMed PMID: 32739797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of COVID-19: A review of the current literature and future perspectives. AU - Ji,Tianxing, AU - Liu,Zhenwei, AU - Wang,GuoQiang, AU - Guo,Xuguang, AU - Akbar Khan,Shahzad, AU - Lai,Changchun, AU - Chen,Haoyu, AU - Huang,Shiwen, AU - Xia,Shaomei, AU - Chen,Bo, AU - Jia,Hongyun, AU - Chen,Yangchao, AU - Zhou,Qiang, Y1 - 2020/07/21/ PY - 2020/03/31/received PY - 2020/07/13/revised PY - 2020/07/14/accepted PY - 2020/8/3/pubmed PY - 2020/9/4/medline PY - 2020/8/3/entrez KW - COVID-19 KW - Point-of-care testing KW - SARS-CoV-2 SP - 112455 EP - 112455 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 166 N2 - The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/32739797/Detection_of_COVID_19:_A_review_of_the_current_literature_and_future_perspectives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(20)30449-8 DB - PRIME DP - Unbound Medicine ER -