TY - JOUR T1 - Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach. AU - Caetano,António Proença, AU - Conde Vasco,Inês, AU - Veloso Gomes,Filipe, AU - Costa,Nuno Vasco, AU - Luz,José Hugo, AU - Spaepen,Erik, AU - Formiga,Ana, AU - Coimbra,Élia, AU - Neves,José, AU - Bilhim,Tiago, Y1 - 2020/08/02/ PY - 2020/5/16/received PY - 2020/7/21/accepted PY - 2020/8/4/pubmed PY - 2021/2/3/medline PY - 2020/8/4/entrez KW - Below-the-knee disease KW - Critical limb ischemia (CLI) KW - Diabetic foot disease KW - Diabetic foot infections KW - Diabetic foot ulcers (DFUs) KW - Diabetic foot wounds KW - Infragenicular arteries KW - Infrapopliteal arteries KW - Limb salvage KW - Major amputation KW - Percutaneous transluminal angioplasty (PTA) KW - Peripheral artery disease KW - Ulceration of the foot SP - 1449 EP - 1459 JF - Cardiovascular and interventional radiology JO - Cardiovasc Intervent Radiol VL - 43 IS - 10 N2 - PURPOSE: Analyze the impact of endovascular revascularization on major amputation rates and wound healing for patients with diabetic foot ulcers (DFUs). MATERIALS AND METHODS: Single-center retrospective study from 2014-2018 including 314 patients with DFUs submitted to endovascular revascularizations. Group A-patients with a successful endovascular revascularization (n = 285; 90.8%); Group B-patients submitted to a failed attempt of endovascular revascularization (n = 29; 9.2%). Baseline data were not significantly different between the 2 groups (p > 0.05). Both groups were compared regarding: major amputation rates; wound healing, mortality and adverse events. Survival and regression analyses were used. RESULTS: Mean follow-up time was 734.1 ± 610.2 days. Major amputation rates were 3.9% versus 24.1% (p < 0.0001) and complete wound healing was 53.7% versus 20.7% (p < 0.0001) for patients from Group A versus Group B, respectively. Major adverse events were registered in 2 patients (one from each group); minor adverse events included 10 patients from Group A and 2 patients from Group B (p = 0.3654). Major amputation rates were: 3.9% versus 27.5% at 1 year; 4.6% versus 27.5% at 2-5 years for Group A versus Group B, respectively (p < 0.0001). Survival rates were: 87.8% at 1 year; 84.4% at 2 years; and 77.9% at 5 years with no significant differences between groups. Predictors for major amputation included failed revascularization (p < 0.0001), older age (p = 0.0394), prior stroke (0.0018), dialysis (0.0476). Predictors for mortality included older age (p < 0.0001) and coronary artery disease (p = 0.0388). CONCLUSION: Endovascular revascularization for patients with DFUs is safe and has a significant impact on limb salvage and wound healing. SN - 1432-086X UR - https://www.unboundmedicine.com/medline/citation/32743744/Successful_Revascularization_has_a_Significant_Impact_on_Limb_Salvage_Rate_and_Wound_Healing_for_Patients_with_Diabetic_Foot_Ulcers:_Single_Centre_Retrospective_Analysis_with_a_Multidisciplinary_Approach_ DB - PRIME DP - Unbound Medicine ER -