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COVID-19, Virology and Geroscience: A Perspective.
J Nutr Health Aging. 2020; 24(7):685-691.JN

Abstract

A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019. The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease 2019 (COVID-19). Older adults have higher peak of viral load and, especially those with comorbidities, had higher COVID-19-related fatality rates than younger adults. In this Perspective paper, we summarize current knowledge about SARS-CoV-2 and aging, in order to understand why older people are more affected by COVID-19. We discuss about the possibility that the so-called "immunosenescence" and "inflammaging" processes, already present in a fraction of frail older adults, could allow the immune escape of SARS-CoV-2 leading to COVID-19 serious complications. Finally, we propose to use geroscience approaches to the field of COVID-19.

Authors+Show Affiliations

Camille Vellas, INSERM UMR1043 - CNRS UMR5282 Centre de Physiopathologie Toulouse-Purpan (CPTP), Toulouse, France, vellas.camille@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32744561

Citation

Vellas, C, et al. "COVID-19, Virology and Geroscience: a Perspective." The Journal of Nutrition, Health & Aging, vol. 24, no. 7, 2020, pp. 685-691.
Vellas C, Delobel P, de Souto Barreto P, et al. COVID-19, Virology and Geroscience: A Perspective. J Nutr Health Aging. 2020;24(7):685-691.
Vellas, C., Delobel, P., de Souto Barreto, P., & Izopet, J. (2020). COVID-19, Virology and Geroscience: A Perspective. The Journal of Nutrition, Health & Aging, 24(7), 685-691. https://doi.org/10.1007/s12603-020-1416-2
Vellas C, et al. COVID-19, Virology and Geroscience: a Perspective. J Nutr Health Aging. 2020;24(7):685-691. PubMed PMID: 32744561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19, Virology and Geroscience: A Perspective. AU - Vellas,C, AU - Delobel,P, AU - de Souto Barreto,P, AU - Izopet,J, PY - 2020/8/4/entrez PY - 2020/8/4/pubmed PY - 2020/8/11/medline KW - COVID-19 KW - SARS-CoV-2 KW - aging KW - coronavirus KW - frailty KW - geroscience KW - prevention SP - 685 EP - 691 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 24 IS - 7 N2 - A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019. The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease 2019 (COVID-19). Older adults have higher peak of viral load and, especially those with comorbidities, had higher COVID-19-related fatality rates than younger adults. In this Perspective paper, we summarize current knowledge about SARS-CoV-2 and aging, in order to understand why older people are more affected by COVID-19. We discuss about the possibility that the so-called "immunosenescence" and "inflammaging" processes, already present in a fraction of frail older adults, could allow the immune escape of SARS-CoV-2 leading to COVID-19 serious complications. Finally, we propose to use geroscience approaches to the field of COVID-19. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/32744561/COVID_19_Virology_and_Geroscience:_A_Perspective_ L2 - https://doi.org/10.1007/s12603-020-1416-2 DB - PRIME DP - Unbound Medicine ER -