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Increased Risk of Hospitalization and Death in Patients with COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico.
Arch Med Res. 2020 10; 51(7):683-689.AM

Abstract

BACKGROUND

The population in Mexico has high prevalence rates of noncommunicable diseases (NCDs). Hospitalization and death of COVID-19 patients in the countries most affected by the pandemic has been associated to chronic comorbidities.

OBJECTIVE

To describe the prevalence of NCDs in patients with COVID-19 in Mexico and analyze the increased risk due to comorbidities and risk factors on hospitalization, utilization of intensive care units and death.

METHODS

A cross-sectional study was performed from 212,802 confirmed COVID-19 cases reported by the Ministry of Health up to June 27, 2020. Odds ratios were performed using logistic regression model.

RESULTS

Up to 47.40% of patients with COVID-19 diagnosis were also reported with a comorbidity, with hypertension being the most frequent (20.12%). The report of at least one NCD significantly increased the risk of death with respect to patients without such diagnoses. Chronic kidney disease increased the risk of death the most (OR 2.31), followed by diabetes (OR 1.69), immunosuppression (OR 1.62), obesity (OR 1.42), hypertension (OR 1.24), chronic obstructive pulmonary disease (OR 1.20). The comorbidities that most increased the risk of ICU and of intubation were diabetes, immunosuppression and obesity.

CONCLUSION

NCD comorbidities increase the severity of COVID-19 infection. Given high NCD prevalence rates among the Mexican population, the pandemic poses a special threat to the health system and to society. Special prevention measures need to be strengthened for persons with NCD diagnoses in the short-term. In the mid-term, disease control strategies need to be improved to protect these patients against COVID-19 severity.

Authors+Show Affiliations

INCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.Universidad Anáhuac México, Instituto Nacional de Salud Pública, Evisys Consulting, Ciudad de México, México.Red Nacional de Registros de Cáncer, Guanajuato, México, Instituto de Salud Pública del Estado de Guanajuato, Unidad de Vigilancia Epidemiologica Hospitalaria, Hospital General León, Guanajuato, México.Secretaría de Salud de Tlaxcala, Dirección General, Tlaxcala, México.Secretaría de Salud de Tlaxcala, Hospital General de Huamantla, Tlaxcala, México; Universidad Autónoma de Tlaxcala, Facultad de Ciencias de la Salud, Tlaxcala, México.Universidad Autónoma de Tlaxcala, Facultad de Ciencias de la Salud, Tlaxcala, México; Secretaría de Salud de Tlaxcala, Centro de Salud Urbano de Villa Vicente Guerrero, Tlaxcala, México.Universidad Autónoma de Tlaxcala, Facultad de Ciencias de la Salud, Tlaxcala, México; Secretaría de Salud de Tlaxcala, Departamento de Calidad y Educación en Salud, Tlaxcala, México. Electronic address: pmendezh@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32747155

Citation

Hernández-Galdamez, Diego Rolando, et al. "Increased Risk of Hospitalization and Death in Patients With COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico." Archives of Medical Research, vol. 51, no. 7, 2020, pp. 683-689.
Hernández-Galdamez DR, González-Block MÁ, Romo-Dueñas DK, et al. Increased Risk of Hospitalization and Death in Patients with COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico. Arch Med Res. 2020;51(7):683-689.
Hernández-Galdamez, D. R., González-Block, M. Á., Romo-Dueñas, D. K., Lima-Morales, R., Hernández-Vicente, I. A., Lumbreras-Guzmán, M., & Méndez-Hernández, P. (2020). Increased Risk of Hospitalization and Death in Patients with COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico. Archives of Medical Research, 51(7), 683-689. https://doi.org/10.1016/j.arcmed.2020.07.003
Hernández-Galdamez DR, et al. Increased Risk of Hospitalization and Death in Patients With COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico. Arch Med Res. 2020;51(7):683-689. PubMed PMID: 32747155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased Risk of Hospitalization and Death in Patients with COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico. AU - Hernández-Galdamez,Diego Rolando, AU - González-Block,Miguel Ángel, AU - Romo-Dueñas,Daniela Karola, AU - Lima-Morales,René, AU - Hernández-Vicente,Irma Alejandra, AU - Lumbreras-Guzmán,Marivel, AU - Méndez-Hernández,Pablo, Y1 - 2020/07/22/ PY - 2020/05/09/received PY - 2020/07/02/revised PY - 2020/07/16/accepted PY - 2020/8/5/pubmed PY - 2020/12/15/medline PY - 2020/8/5/entrez KW - COVID-19 KW - Comorbidities KW - Endotracheal intubation KW - Intensive care unit KW - Modifiable risk factors KW - Non-communicable diseases KW - SARS-CoV-2 SP - 683 EP - 689 JF - Archives of medical research JO - Arch Med Res VL - 51 IS - 7 N2 - BACKGROUND: The population in Mexico has high prevalence rates of noncommunicable diseases (NCDs). Hospitalization and death of COVID-19 patients in the countries most affected by the pandemic has been associated to chronic comorbidities. OBJECTIVE: To describe the prevalence of NCDs in patients with COVID-19 in Mexico and analyze the increased risk due to comorbidities and risk factors on hospitalization, utilization of intensive care units and death. METHODS: A cross-sectional study was performed from 212,802 confirmed COVID-19 cases reported by the Ministry of Health up to June 27, 2020. Odds ratios were performed using logistic regression model. RESULTS: Up to 47.40% of patients with COVID-19 diagnosis were also reported with a comorbidity, with hypertension being the most frequent (20.12%). The report of at least one NCD significantly increased the risk of death with respect to patients without such diagnoses. Chronic kidney disease increased the risk of death the most (OR 2.31), followed by diabetes (OR 1.69), immunosuppression (OR 1.62), obesity (OR 1.42), hypertension (OR 1.24), chronic obstructive pulmonary disease (OR 1.20). The comorbidities that most increased the risk of ICU and of intubation were diabetes, immunosuppression and obesity. CONCLUSION: NCD comorbidities increase the severity of COVID-19 infection. Given high NCD prevalence rates among the Mexican population, the pandemic poses a special threat to the health system and to society. Special prevention measures need to be strengthened for persons with NCD diagnoses in the short-term. In the mid-term, disease control strategies need to be improved to protect these patients against COVID-19 severity. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/32747155/Increased_Risk_of_Hospitalization_and_Death_in_Patients_with_COVID_19_and_Pre_existing_Noncommunicable_Diseases_and_Modifiable_Risk_Factors_in_Mexico_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(20)30722-0 DB - PRIME DP - Unbound Medicine ER -