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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.
Acta Pharmacol Sin. 2020 Sep; 41(9):1141-1149.AP

Abstract

Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.

Authors+Show Affiliations

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. xuwei3322@smu.edu.cn.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. liusw@smu.edu.cn. State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, 510515, China. liusw@smu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32747721

Citation

Huang, Yuan, et al. "Structural and Functional Properties of SARS-CoV-2 Spike Protein: Potential Antivirus Drug Development for COVID-19." Acta Pharmacologica Sinica, vol. 41, no. 9, 2020, pp. 1141-1149.
Huang Y, Yang C, Xu XF, et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020;41(9):1141-1149.
Huang, Y., Yang, C., Xu, X. F., Xu, W., & Liu, S. W. (2020). Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica, 41(9), 1141-1149. https://doi.org/10.1038/s41401-020-0485-4
Huang Y, et al. Structural and Functional Properties of SARS-CoV-2 Spike Protein: Potential Antivirus Drug Development for COVID-19. Acta Pharmacol Sin. 2020;41(9):1141-1149. PubMed PMID: 32747721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. AU - Huang,Yuan, AU - Yang,Chan, AU - Xu,Xin-Feng, AU - Xu,Wei, AU - Liu,Shu-Wen, Y1 - 2020/08/03/ PY - 2020/05/15/received PY - 2020/07/15/accepted PY - 2020/8/5/pubmed PY - 2020/9/9/medline PY - 2020/8/5/entrez KW - SARS-CoV-2 virus KW - antibodies KW - antivirus drugs KW - fusion inhibitors; host proteases inhibitors KW - spike protein SP - 1141 EP - 1149 JF - Acta pharmacologica Sinica JO - Acta Pharmacol. Sin. VL - 41 IS - 9 N2 - Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein. SN - 1745-7254 UR - https://www.unboundmedicine.com/medline/citation/32747721/Structural_and_functional_properties_of_SARS_CoV_2_spike_protein:_potential_antivirus_drug_development_for_COVID_19_ L2 - http://dx.doi.org/10.1038/s41401-020-0485-4 DB - PRIME DP - Unbound Medicine ER -