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Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.Front Endocrinol (Lausanne). 2020; 11:525.FE
Abstract
Background:
Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19.Methods:
In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models.Results:
The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities.Conclusion:
IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.Links
MeSH
AdultAgedBetacoronavirusBlood GlucoseCOVID-19ChinaCoronavirus InfectionsDiabetes ComplicationsDiabetes MellitusFastingFemaleFollow-Up StudiesGlucose IntoleranceHospital MortalityHospitalizationHumansHyperglycemiaMaleMiddle AgedPandemicsPneumonia, ViralPrognosisRetrospective StudiesRisk FactorsSARS-CoV-2Severity of Illness IndexSurvival Rate
Pub Type(s)
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
32754119
Citation
Zhang, Jiaoyue, et al. "Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019." Frontiers in Endocrinology, vol. 11, 2020, p. 525.
Zhang J, Kong W, Xia P, et al. Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019. Front Endocrinol (Lausanne). 2020;11:525.
Zhang, J., Kong, W., Xia, P., Xu, Y., Li, L., Li, Q., Yang, L., Wei, Q., Wang, H., Li, H., Zheng, J., Sun, H., Xia, W., Liu, G., Zhong, X., Qiu, K., Li, Y., Wang, H., Wang, Y., ... Zeng, T. (2020). Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019. Frontiers in Endocrinology, 11, 525. https://doi.org/10.3389/fendo.2020.00525
Zhang J, et al. Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019. Front Endocrinol (Lausanne). 2020;11:525. PubMed PMID: 32754119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.
AU - Zhang,Jiaoyue,
AU - Kong,Wen,
AU - Xia,Pengfei,
AU - Xu,Ying,
AU - Li,Li,
AU - Li,Qin,
AU - Yang,Li,
AU - Wei,Qi,
AU - Wang,Hanyu,
AU - Li,Huiqing,
AU - Zheng,Juan,
AU - Sun,Hui,
AU - Xia,Wenfang,
AU - Liu,Geng,
AU - Zhong,Xueyu,
AU - Qiu,Kangli,
AU - Li,Yan,
AU - Wang,Han,
AU - Wang,Yuxiu,
AU - Song,Xiaoli,
AU - Liu,Hua,
AU - Xiong,Si,
AU - Liu,Yumei,
AU - Cui,Zhenhai,
AU - Hu,Yu,
AU - Chen,Lulu,
AU - Pan,An,
AU - Zeng,Tianshu,
Y1 - 2020/07/10/
PY - 2020/05/27/received
PY - 2020/06/29/accepted
PY - 2020/8/6/entrez
PY - 2020/8/6/pubmed
PY - 2020/8/22/medline
KW - COVID-19
KW - cohort study
KW - coronavirus
KW - diabetes
KW - hyperglycemia
KW - impaired fasting glucose
KW - severe acute respiratory coronavirus 2 (SARS-CoV-2)
SP - 525
EP - 525
JF - Frontiers in endocrinology
JO - Front Endocrinol (Lausanne)
VL - 11
N2 - Background: Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. Methods: In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. Results: The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. Conclusion: IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
SN - 1664-2392
UR - https://www.unboundmedicine.com/medline/citation/32754119/Impaired_Fasting_Glucose_and_Diabetes_Are_Related_to_Higher_Risks_of_Complications_and_Mortality_Among_Patients_With_Coronavirus_Disease_2019_
L2 - https://doi.org/10.3389/fendo.2020.00525
DB - PRIME
DP - Unbound Medicine
ER -