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The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea.
J Neurogastroenterol Motil. 2020 Aug 06 [Online ahead of print]JN

Abstract

Background/Aims

As there is insufficient evidence for a relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), we investigated whether OSA diagnosed by polysomnography (PSG) is related to GERD.

Methods

A total of 402 subjects was evaluated. Overnight PSG was performed and a few questionnaires on GERD, anxiety, depression, and daytime sleepiness were administered. An apnea-hypopnea index < 5 was the classification criterion for subjects without OSA. Subjects with heartburn or acid regurgitation at least once a week were classified as having GERD.

Results

Among the 402 subjects, 318 had OSA and 84 did not. The prevalence of GERD was 12.9% among patients with OSA and 10.7% among those without (P = 0.590). The prevalence of GERD did not correlate with OSA severity (P = 0.474). Patients with OSA with GERD had higher Stanford Sleepiness Scale (P = 0.004), Epworth Sleepiness Scale (P = 0.001), and depression (P < 0.001) scores than patients with OSA without GERD. Subjects with nocturnal gastroesophageal reflux symptoms had a higher body mass index, waist-to-height ratio, and waist circumference-to-height index than those without symptoms. Multiple logistic regression showed that higher Epworth Sleepiness Scale and depression scores were independent factors associated with GERD in patients with OSA.

Conclusions

The prevalence of GERD in patients with OSA was 12.9%. The prevalence of GERD did not correlate with OSA severity. Daytime sleepiness and depression seem to be associated with GERD in patients with OSA, while nocturnal reflux symptoms seem to be related to obesity in OSA.

Authors+Show Affiliations

Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32759463

Citation

Kang, Hyeon Hui, et al. "The Influence of Gastroesophageal Reflux Disease On Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea." Journal of Neurogastroenterology and Motility, 2020.
Kang HH, Lim CH, Oh JH, et al. The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea. J Neurogastroenterol Motil. 2020.
Kang, H. H., Lim, C. H., Oh, J. H., Cho, M. J., & Lee, S. H. (2020). The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea. Journal of Neurogastroenterology and Motility. https://doi.org/10.5056/jnm20071
Kang HH, et al. The Influence of Gastroesophageal Reflux Disease On Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea. J Neurogastroenterol Motil. 2020 Aug 6; PubMed PMID: 32759463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea. AU - Kang,Hyeon Hui, AU - Lim,Chul-Hyun, AU - Oh,Jung Hwan, AU - Cho,Min-Jae, AU - Lee,Sang Haak, Y1 - 2020/08/06/ PY - 2020/04/10/received PY - 2020/06/01/revised PY - 2020/06/15/accepted PY - 2020/8/8/entrez KW - Depression KW - Gastroesophageal reflux KW - Obesity KW - Polysomnography KW - Sleep apnea, obstructive JF - Journal of neurogastroenterology and motility JO - J Neurogastroenterol Motil N2 - Background/Aims: As there is insufficient evidence for a relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), we investigated whether OSA diagnosed by polysomnography (PSG) is related to GERD. Methods: A total of 402 subjects was evaluated. Overnight PSG was performed and a few questionnaires on GERD, anxiety, depression, and daytime sleepiness were administered. An apnea-hypopnea index < 5 was the classification criterion for subjects without OSA. Subjects with heartburn or acid regurgitation at least once a week were classified as having GERD. Results: Among the 402 subjects, 318 had OSA and 84 did not. The prevalence of GERD was 12.9% among patients with OSA and 10.7% among those without (P = 0.590). The prevalence of GERD did not correlate with OSA severity (P = 0.474). Patients with OSA with GERD had higher Stanford Sleepiness Scale (P = 0.004), Epworth Sleepiness Scale (P = 0.001), and depression (P < 0.001) scores than patients with OSA without GERD. Subjects with nocturnal gastroesophageal reflux symptoms had a higher body mass index, waist-to-height ratio, and waist circumference-to-height index than those without symptoms. Multiple logistic regression showed that higher Epworth Sleepiness Scale and depression scores were independent factors associated with GERD in patients with OSA. Conclusions: The prevalence of GERD in patients with OSA was 12.9%. The prevalence of GERD did not correlate with OSA severity. Daytime sleepiness and depression seem to be associated with GERD in patients with OSA, while nocturnal reflux symptoms seem to be related to obesity in OSA. SN - 2093-0879 UR - https://www.unboundmedicine.com/medline/citation/32759463/The_Influence_of_Gastroesophageal_Reflux_Disease_on_Daytime_Sleepiness_and_Depressive_Symptom_in_Patients_With_Obstructive_Sleep_Apnea_ L2 - http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm20071 DB - PRIME DP - Unbound Medicine ER -
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