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Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report.
Front Med (Lausanne). 2020; 7:428.FM

Abstract

A severe multisystem inflammatory syndrome associated with Kawasaki disease manifestations (MIS-C) has been recently reported in children with signs of recent infection with SARS-CoV-2. We here reported the case of a young adult woman who presented the complete manifestations of Kawasaki disease associated with a severe myocarditis, acute respiratory distress syndrome and hemodynamic instability a few weeks after a transient anosmia. The detection of specific antibodies to SARS-CoV-2 in the absence of detection of the virus suggested that the syndrome was the result of a delayed immune response to a recent COVID-19 infection. A combined treatment with colchicine, tocilizumab, high dose immunoglobulins, and methylprednisolone allowed to control the inflammatory process and to limit the development of coronary aneurysm. The patient recovered without sequelae. This case emphasized the importance of SARS-CoV-2 serology for the diagnosis of delayed immune complications of COVID-19. Clinicians caring for adult patients must be aware that not only children but also young adults can be affected by a multisystem inflammatory syndrome with KD features associated with COVID-19.

Authors+Show Affiliations

Department of Internal Medicine, CHIREC Hospital, Brussels, Belgium. Université Libre de Bruxelles (ULB), Brussels, Belgium.Department of Intensive Care, CHIREC Hospital, Brussels, Belgium.Department of Radiology, CHIREC Hospital, Brussels, Belgium.Department of Biochemistry, CHIREC Hospital, Brussels, Belgium.Department of Infectious Diseases, CHIREC Hospital, Brussels, Belgium.Université Libre de Bruxelles (ULB), Brussels, Belgium. Department of Intensive Care, CHIREC Hospital, Brussels, Belgium.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32760733

Citation

Cogan, Elie, et al. "Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. a Case Report." Frontiers in Medicine, vol. 7, 2020, p. 428.
Cogan E, Foulon P, Cappeliez O, et al. Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report. Frontiers in medicine. 2020;7:428.
Cogan, E., Foulon, P., Cappeliez, O., Dolle, N., Vanfraechem, G., & De Backer, D. (2020). Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report. Frontiers in Medicine, 7, 428. https://doi.org/10.3389/fmed.2020.00428
Cogan E, et al. Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. a Case Report. Frontiers in medicine. 2020;7:428. PubMed PMID: 32760733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report. AU - Cogan,Elie, AU - Foulon,Pierre, AU - Cappeliez,Olivier, AU - Dolle,Nicole, AU - Vanfraechem,Gaëlle, AU - De Backer,Daniel, Y1 - 2020/07/14/ PY - 2020/05/25/received PY - 2020/07/02/accepted PY - 2020/8/8/entrez PY - 2020/8/8/pubmed PY - 2020/8/8/medline KW - COVID-19 KW - Kawasaki disease KW - MIS-C KW - SARS-CoV-2 KW - case report KW - serology KW - tocilizumab SP - 428 EP - 428 JF - Frontiers in medicine VL - 7 N2 - A severe multisystem inflammatory syndrome associated with Kawasaki disease manifestations (MIS-C) has been recently reported in children with signs of recent infection with SARS-CoV-2. We here reported the case of a young adult woman who presented the complete manifestations of Kawasaki disease associated with a severe myocarditis, acute respiratory distress syndrome and hemodynamic instability a few weeks after a transient anosmia. The detection of specific antibodies to SARS-CoV-2 in the absence of detection of the virus suggested that the syndrome was the result of a delayed immune response to a recent COVID-19 infection. A combined treatment with colchicine, tocilizumab, high dose immunoglobulins, and methylprednisolone allowed to control the inflammatory process and to limit the development of coronary aneurysm. The patient recovered without sequelae. This case emphasized the importance of SARS-CoV-2 serology for the diagnosis of delayed immune complications of COVID-19. Clinicians caring for adult patients must be aware that not only children but also young adults can be affected by a multisystem inflammatory syndrome with KD features associated with COVID-19. SN - 2296-858X UR - https://www.unboundmedicine.com/medline/citation/32760733/Multisystem_Inflammatory_Syndrome_With_Complete_Kawasaki_Disease_Features_Associated_With_SARS_CoV_2_Infection_in_a_Young_Adult__A_Case_Report_ L2 - https://doi.org/10.3389/fmed.2020.00428 DB - PRIME DP - Unbound Medicine ER -
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