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[Replication and transmission mechanisms of highly pathogenic human coronavirus].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25; 49(3):324-339.ZD

Abstract

The three known highly pathogenic human coronaviruses are severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human highly pathogenic coronaviruses are composed of non-structural proteins, structural proteins, accessory proteins and ribonucleic acid. Viral particles recognize host receptors via spike glycoprotein (S protein), enter host cells by membrane fusion, replicate in host cells through large replication-transcription complexes, and promote proliferation by interfering with and suppressing the host's immune response. Highly pathogenic human coronaviruses are hosted by humans and vertebrates. Viral particles are transmitted through droplets, contact and aerosols or likely through digestive tract, urine, eyes and other routes. This review discusses the mechanisms of replication and transmission of highly pathogenic human coronaviruses providing basis for future studies on interrupting the transmission and pathogenicity of these pathogenic viruses.

Authors+Show Affiliations

College of Animal Science and Technology·College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou 310029, China. College of Biomedical Engineering and Instrument Science, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China. Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China.

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

32762165

Citation

He, Yeyan, and Chanying Zheng. "[Replication and Transmission Mechanisms of Highly Pathogenic Human Coronavirus]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 49, no. 3, 2020, pp. 324-339.
He Y, Zheng C. [Replication and transmission mechanisms of highly pathogenic human coronavirus]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49(3):324-339.
He, Y., & Zheng, C. (2020). [Replication and transmission mechanisms of highly pathogenic human coronavirus]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 49(3), 324-339. https://doi.org/10.3785/j.issn.1008-9292.2020.06.01
He Y, Zheng C. [Replication and Transmission Mechanisms of Highly Pathogenic Human Coronavirus]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(3):324-339. PubMed PMID: 32762165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Replication and transmission mechanisms of highly pathogenic human coronavirus]. AU - He,Yeyan, AU - Zheng,Chanying, PY - 2020/8/8/entrez PY - 2020/8/8/pubmed PY - 2020/8/13/medline SP - 324 EP - 339 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 49 IS - 3 N2 - The three known highly pathogenic human coronaviruses are severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human highly pathogenic coronaviruses are composed of non-structural proteins, structural proteins, accessory proteins and ribonucleic acid. Viral particles recognize host receptors via spike glycoprotein (S protein), enter host cells by membrane fusion, replicate in host cells through large replication-transcription complexes, and promote proliferation by interfering with and suppressing the host's immune response. Highly pathogenic human coronaviruses are hosted by humans and vertebrates. Viral particles are transmitted through droplets, contact and aerosols or likely through digestive tract, urine, eyes and other routes. This review discusses the mechanisms of replication and transmission of highly pathogenic human coronaviruses providing basis for future studies on interrupting the transmission and pathogenicity of these pathogenic viruses. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/32762165/[Replication_and_transmission_mechanisms_of_highly_pathogenic_human_coronavirus] DB - PRIME DP - Unbound Medicine ER -