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Sudden onset, acute loss of taste and smell in coronavirus disease 2019 (COVID-19): a systematic review.
Acta Odontol Scand. 2020 Aug; 78(6):467-473.AO

Abstract

BACKGROUND

Early detection, isolation and management of COVID-19 are crucial to contain the current pandemic. US Centers for Disease Control and Prevention (CDC) recently included 'sudden loss of taste (dysgeusia/ageusia) and smell (anosmia/hyposmia)' as symptoms of COVID-19. If indeed these symptoms are reliable and specific forerunner symptoms of COVID-19, then it may facilitate detection and containment of the disease. Hence, we systematically evaluated the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients.

METHODS

Ovid MEDLINE, EBSCO host and Web of Science databases were searched between 25 December 2019 and 30 May 2020.

RESULTS

Of the 13 identified records, eight studies, totalling 11,054 COVID-19 patients, were included, as per the selection criteria. Eligible articles reflected research conducted mostly in the European community, as well as China, the US and Iran. In total, anosmia and dysgeusia symptoms were present in 74.9% and 81.3% ambulatory as well as hospitalized, mild-to-severe cases of COVID-19 patients, respectively. The European, US and Iran data indicate olfactory and gustatory symptoms appear prior to general COVID-19 symptoms in 64.5% and 54.0% of the patients, respectively.

CONCLUSIONS

To our knowledge, this is the first systematic review analysing the meager data based on the prevalence of chemosensory dysfunction in COVID-19. Critical analysis of such macro-data, as and when available, is essential to evaluate their utility as harbingers of COVID-19 onset, and to establish clinical practice guidelines both in dentistry and medicine.

Authors+Show Affiliations

Departments of Preventive and Restorative Dentistry and Oral and Craniofacial Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region, China.Departments of Preventive and Restorative Dentistry and Oral and Craniofacial Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.Departments of Preventive and Restorative Dentistry and Oral and Craniofacial Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32762282

Citation

Samaranayake, Lakshman Perera, et al. "Sudden Onset, Acute Loss of Taste and Smell in Coronavirus Disease 2019 (COVID-19): a Systematic Review." Acta Odontologica Scandinavica, vol. 78, no. 6, 2020, pp. 467-473.
Samaranayake LP, Fakhruddin KS, Panduwawala C. Sudden onset, acute loss of taste and smell in coronavirus disease 2019 (COVID-19): a systematic review. Acta Odontol Scand. 2020;78(6):467-473.
Samaranayake, L. P., Fakhruddin, K. S., & Panduwawala, C. (2020). Sudden onset, acute loss of taste and smell in coronavirus disease 2019 (COVID-19): a systematic review. Acta Odontologica Scandinavica, 78(6), 467-473. https://doi.org/10.1080/00016357.2020.1787505
Samaranayake LP, Fakhruddin KS, Panduwawala C. Sudden Onset, Acute Loss of Taste and Smell in Coronavirus Disease 2019 (COVID-19): a Systematic Review. Acta Odontol Scand. 2020;78(6):467-473. PubMed PMID: 32762282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sudden onset, acute loss of taste and smell in coronavirus disease 2019 (COVID-19): a systematic review. AU - Samaranayake,Lakshman Perera, AU - Fakhruddin,Kausar Sadia, AU - Panduwawala,Chamila, Y1 - 2020/08/07/ PY - 2020/8/9/pubmed PY - 2020/8/22/medline PY - 2020/8/9/entrez KW - COVID-19 KW - Loss of taste KW - SARS-CoV-2 KW - anosmia KW - chemosensory dysfunction KW - dysgeusia KW - loss of smell SP - 467 EP - 473 JF - Acta odontologica Scandinavica JO - Acta Odontol. Scand. VL - 78 IS - 6 N2 - BACKGROUND: Early detection, isolation and management of COVID-19 are crucial to contain the current pandemic. US Centers for Disease Control and Prevention (CDC) recently included 'sudden loss of taste (dysgeusia/ageusia) and smell (anosmia/hyposmia)' as symptoms of COVID-19. If indeed these symptoms are reliable and specific forerunner symptoms of COVID-19, then it may facilitate detection and containment of the disease. Hence, we systematically evaluated the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients. METHODS: Ovid MEDLINE, EBSCO host and Web of Science databases were searched between 25 December 2019 and 30 May 2020. RESULTS: Of the 13 identified records, eight studies, totalling 11,054 COVID-19 patients, were included, as per the selection criteria. Eligible articles reflected research conducted mostly in the European community, as well as China, the US and Iran. In total, anosmia and dysgeusia symptoms were present in 74.9% and 81.3% ambulatory as well as hospitalized, mild-to-severe cases of COVID-19 patients, respectively. The European, US and Iran data indicate olfactory and gustatory symptoms appear prior to general COVID-19 symptoms in 64.5% and 54.0% of the patients, respectively. CONCLUSIONS: To our knowledge, this is the first systematic review analysing the meager data based on the prevalence of chemosensory dysfunction in COVID-19. Critical analysis of such macro-data, as and when available, is essential to evaluate their utility as harbingers of COVID-19 onset, and to establish clinical practice guidelines both in dentistry and medicine. SN - 1502-3850 UR - https://www.unboundmedicine.com/medline/citation/32762282/Sudden_onset_acute_loss_of_taste_and_smell_in_coronavirus_disease_2019__COVID_19_:_a_systematic_review_ L2 - http://www.tandfonline.com/doi/full/10.1080/00016357.2020.1787505 DB - PRIME DP - Unbound Medicine ER -