Tags

Type your tag names separated by a space and hit enter

Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives.
JCO Glob Oncol. 2020 Aug; 6:1264-1275.JG

Abstract

PURPOSE

Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations.

METHODS

The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges.

RESULTS

The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry's classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources.

CONCLUSION

While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.

Authors+Show Affiliations

Department of Pediatric Haematology and Oncology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium. Department of Pediatric Oncology, Uganda Cancer Institute, Kampala, Uganda.Radiation Oncology Department, National Cancer Institute, Cairo University and Children's Cancer Hospital, Cairo, Egypt.Department of Pediatric Oncology, Uganda Cancer Institute, Kampala, Uganda. Statistics Department, European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.Department of Pediatric Oncology, Uganda Cancer Institute, Kampala, Uganda. Pediatric OncoGenomics Unit, Pediatric Oncology-Hematology Department, Children's University Hospital Niño Jesús, Madrid, Spain.Faculty of Health Sciences, Division of Pediatric Haematology and Oncology, Department of Pediatrics and Child Health, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.Franco-African Pediatric Oncology Group and Gustave Roussy Institute, Villejuif, France.Department of Pediatric Oncology, Uganda Cancer Institute, Kampala, Uganda.Department of Pediatrics and Child Health, Tygerberg Childrens' Hospital, University of Stellenbosch, Stellenbosch, South Africa.Banso Baptist Hospital, Kumbo, Cameroon.Pediatric Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.Pediatric Haematology and Oncology Center, University Mohamed V. Rabat, Rabat, Morocco.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32762563

Citation

van Heerden, Jaques, et al. "Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives." JCO Global Oncology, vol. 6, 2020, pp. 1264-1275.
van Heerden J, Zaghloul M, Neven A, et al. Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives. JCO Glob Oncol. 2020;6:1264-1275.
van Heerden, J., Zaghloul, M., Neven, A., de Rojas, T., Geel, J., Patte, C., Balagadde-Kambugu, J., Hesseling, P., Tchintseme, F., Bouffet, E., & Hessissen, L. (2020). Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives. JCO Global Oncology, 6, 1264-1275. https://doi.org/10.1200/GO.20.00159
van Heerden J, et al. Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives. JCO Glob Oncol. 2020;6:1264-1275. PubMed PMID: 32762563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives. AU - van Heerden,Jaques, AU - Zaghloul,Mohamed, AU - Neven,Anouk, AU - de Rojas,Teresa, AU - Geel,Jennifer, AU - Patte,Catherine, AU - Balagadde-Kambugu,Joyce, AU - Hesseling,Peter, AU - Tchintseme,Francine, AU - Bouffet,Eric, AU - Hessissen,Laila, AU - ,, PY - 2020/8/9/entrez PY - 2020/8/9/pubmed PY - 2020/8/9/medline SP - 1264 EP - 1275 JF - JCO global oncology JO - JCO Glob Oncol VL - 6 N2 - PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS: The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS: The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry's classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION: While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output. SN - 2687-8941 UR - https://www.unboundmedicine.com/medline/citation/32762563/Pediatric_Oncology_Clinical_Trials_and_Collaborative_Research_in_Africa:_Current_Landscape_and_Future_Perspectives_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.