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Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients.
J Otolaryngol Head Neck Surg. 2020 Aug 06; 49(1):56.JO

Abstract

BACKGROUND

The lack of objective data makes it difficult to establish the prognostic value of chemosensitive disorders in coronavirus disease 2019 (COVID-19) patients. We aimed to prospectively monitor patients diagnosed with COVID-19 to see if the severity of olfactory and gustatory dysfunction associates with subsequent disease severity.

METHODS

Multicentre prospective study that recruited 106 COVID-19 subjects at diagnosis. Chemosensitive functions were assessed with psychophysical tests within 4 days of clinical onset, at 10 and 20 days. Daily body temperature and oxygen saturation were recorded as markers of disease severity alongside need for hospitalisation. The correlation between olfactory and gustatory scores and disease severity was assessed with linear regression analysis.

RESULTS

At T0, 71 patients (67%) presented with olfactory dysfunction while gustatory impairment was detected in 76 cases (65.6%). Chemosensitive disorders gradually improved over the observation period. No significant correlations were found between T0 chemosensitive scores and final disease severity. The correlation between olfactory scores and fever proved significant at T2 (p = 0.05), while the relationship with gustatory scores was significant at T1 (p = 0.01) and T2 (p < 0.001), however neither was clinically relevant. The correlation between chemosensitive scores and oxygen saturation was significant only for taste at T2 (p < 0.001). Logistic regression analysis found significant correlations between olfactory impairment severity and need for hospitalization at T2 (OR 3.750, p = 0.005).

CONCLUSIONS

Initial objective olfactory and gustatory scores do not seem to have a significant prognostic value in predicting the severity of the COVID-19 course; however, persistence of olfactory dysfunction at 20 days, associated with a more severe course. Unfortunately, olfactory and gustatory dysfunction do not seem to hold prognostic value at the time of initial diagnosis.

Authors+Show Affiliations

Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.Guy's Hospital, King's College, London, UK. clairehopkins@yahoo.com.Maxillofacial Surgery Operative Unit, Bellaria and Maggiore Hospital, AUSL Bologna, Bologna, Italy.. Department of Human and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.Otolaryngology Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.Maxillofacial Surgery Unit, University Hospital of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.Maxillofacial Surgery Unit, University Hospital of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.. Department of Human and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32762737

Citation

Vaira, Luigi Angelo, et al. "Do Olfactory and Gustatory Psychophysical Scores Have Prognostic Value in COVID-19 Patients? a Prospective Study of 106 Patients." Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale, vol. 49, no. 1, 2020, p. 56.
Vaira LA, Hopkins C, Petrocelli M, et al. Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. J Otolaryngol Head Neck Surg. 2020;49(1):56.
Vaira, L. A., Hopkins, C., Petrocelli, M., Lechien, J. R., Soma, D., Giovanditto, F., Rizzo, D., Salzano, G., Piombino, P., Saussez, S., & De Riu, G. (2020). Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale, 49(1), 56. https://doi.org/10.1186/s40463-020-00449-y
Vaira LA, et al. Do Olfactory and Gustatory Psychophysical Scores Have Prognostic Value in COVID-19 Patients? a Prospective Study of 106 Patients. J Otolaryngol Head Neck Surg. 2020 Aug 6;49(1):56. PubMed PMID: 32762737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. AU - Vaira,Luigi Angelo, AU - Hopkins,Claire, AU - Petrocelli,Marzia, AU - Lechien,Jerome R, AU - Soma,Damiano, AU - Giovanditto,Federica, AU - Rizzo,Davide, AU - Salzano,Giovanni, AU - Piombino,Pasquale, AU - Saussez,Sven, AU - De Riu,Giacomo, Y1 - 2020/08/06/ PY - 2020/06/11/received PY - 2020/07/14/accepted PY - 2020/8/9/entrez PY - 2020/8/9/pubmed PY - 2020/8/15/medline KW - Ageusia KW - Anosmia KW - COVID-19 KW - Gustatory KW - Olfactory SP - 56 EP - 56 JF - Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale JO - J Otolaryngol Head Neck Surg VL - 49 IS - 1 N2 - BACKGROUND: The lack of objective data makes it difficult to establish the prognostic value of chemosensitive disorders in coronavirus disease 2019 (COVID-19) patients. We aimed to prospectively monitor patients diagnosed with COVID-19 to see if the severity of olfactory and gustatory dysfunction associates with subsequent disease severity. METHODS: Multicentre prospective study that recruited 106 COVID-19 subjects at diagnosis. Chemosensitive functions were assessed with psychophysical tests within 4 days of clinical onset, at 10 and 20 days. Daily body temperature and oxygen saturation were recorded as markers of disease severity alongside need for hospitalisation. The correlation between olfactory and gustatory scores and disease severity was assessed with linear regression analysis. RESULTS: At T0, 71 patients (67%) presented with olfactory dysfunction while gustatory impairment was detected in 76 cases (65.6%). Chemosensitive disorders gradually improved over the observation period. No significant correlations were found between T0 chemosensitive scores and final disease severity. The correlation between olfactory scores and fever proved significant at T2 (p = 0.05), while the relationship with gustatory scores was significant at T1 (p = 0.01) and T2 (p < 0.001), however neither was clinically relevant. The correlation between chemosensitive scores and oxygen saturation was significant only for taste at T2 (p < 0.001). Logistic regression analysis found significant correlations between olfactory impairment severity and need for hospitalization at T2 (OR 3.750, p = 0.005). CONCLUSIONS: Initial objective olfactory and gustatory scores do not seem to have a significant prognostic value in predicting the severity of the COVID-19 course; however, persistence of olfactory dysfunction at 20 days, associated with a more severe course. Unfortunately, olfactory and gustatory dysfunction do not seem to hold prognostic value at the time of initial diagnosis. SN - 1916-0216 UR - https://www.unboundmedicine.com/medline/citation/32762737/Do_olfactory_and_gustatory_psychophysical_scores_have_prognostic_value_in_COVID_19_patients_A_prospective_study_of_106_patients_ L2 - https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00449-y DB - PRIME DP - Unbound Medicine ER -