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Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective.
Eur J Pharmacol. 2020 Nov 05; 886:173447.EJ

Abstract

Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients.

Authors+Show Affiliations

Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.Bioinformatics Dept., Agricultural Genetic Engineering Research Institute (AGERI), Bioinformatics and Functional Genomics Dept., College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.Department of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.Department of Physics, Institute for Medical Research and Consultations, Imam Abdulrahman Bin Faisal University, P. O. Box: 1982, 31441, Dammam, Saudi Arabia.Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.Department of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, PR China.Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan No.44, Wuhan, PR China; University of Chinese Academy of Sciences, Beijing, 100049, China.Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: hhsabit@iau.edu.sa.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32763302

Citation

Khan, Suliman, et al. "Coronavirus Diseases 2019: Current Biological Situation and Potential Therapeutic Perspective." European Journal of Pharmacology, vol. 886, 2020, p. 173447.
Khan S, Tombuloglu H, Hassanein SE, et al. Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective. Eur J Pharmacol. 2020;886:173447.
Khan, S., Tombuloglu, H., Hassanein, S. E., Rehman, S., Bozkurt, A., Cevik, E., Abdel-Ghany, S., Nabi, G., Ali, A., & Sabit, H. (2020). Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective. European Journal of Pharmacology, 886, 173447. https://doi.org/10.1016/j.ejphar.2020.173447
Khan S, et al. Coronavirus Diseases 2019: Current Biological Situation and Potential Therapeutic Perspective. Eur J Pharmacol. 2020 Nov 5;886:173447. PubMed PMID: 32763302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective. AU - Khan,Suliman, AU - Tombuloglu,Huseyin, AU - Hassanein,Sameh E, AU - Rehman,Suriya, AU - Bozkurt,Ayhan, AU - Cevik,Emre, AU - Abdel-Ghany,Shaimaa, AU - Nabi,Ghulam, AU - Ali,Ashaq, AU - Sabit,Hussein, Y1 - 2020/08/05/ PY - 2020/05/26/received PY - 2020/07/19/revised PY - 2020/07/29/accepted PY - 2020/8/9/pubmed PY - 2020/10/27/medline PY - 2020/8/9/entrez KW - COVID-19 KW - Coronavirus KW - Mortality KW - Pathogenicity KW - SARS-CoV-2 KW - Treatment SP - 173447 EP - 173447 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 886 N2 - Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/32763302/Coronavirus_diseases_2019:_Current_biological_situation_and_potential_therapeutic_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(20)30539-2 DB - PRIME DP - Unbound Medicine ER -