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Susceptibility of SARS-CoV-2 to UV irradiation.
Am J Infect Control. 2020 10; 48(10):1273-1275.AJ

Abstract

The coronavirus SARS-CoV-2 pandemic became a global health burden. We determined the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The virus was highly susceptible to ultraviolet light. A viral stock with a high infectious titer of 5 × 106 TCID50/mL was completely inactivated by UVC irradiation after nine minutes of exposure. The UVC dose required for complete inactivation was 1,048 mJ/cm2. UVA exposure demonstrated only a weak effect on virus inactivation over 15 minutes. Hence, inactivation of SARS-CoV-2 by UVC irradiation constitutes a reliable method for disinfection purposes in health care facilities and for preparing SARS-CoV-2 material for research purpose.

Authors+Show Affiliations

Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany.Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany.Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany.Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany.Hust Huazhong University of Science & Technology, Wuhan Union Hospital, Department of Infectious Diseases, Wuhan, China; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany.Hust Huazhong University of Science & Technology, Wuhan Union Hospital, Department of Infectious Diseases, Wuhan, China; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany.Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany.Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany.Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany.Department of Molecular and Medical Virology, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany.Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Germany; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Wuhan-Essen Joint International Laboratory of Infection and Immunity, Essen, Germany. Electronic address: adalbert.krawczyk@uni-due.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32763344

Citation

Heilingloh, Christiane Silke, et al. "Susceptibility of SARS-CoV-2 to UV Irradiation." American Journal of Infection Control, vol. 48, no. 10, 2020, pp. 1273-1275.
Heilingloh CS, Aufderhorst UW, Schipper L, et al. Susceptibility of SARS-CoV-2 to UV irradiation. Am J Infect Control. 2020;48(10):1273-1275.
Heilingloh, C. S., Aufderhorst, U. W., Schipper, L., Dittmer, U., Witzke, O., Yang, D., Zheng, X., Sutter, K., Trilling, M., Alt, M., Steinmann, E., & Krawczyk, A. (2020). Susceptibility of SARS-CoV-2 to UV irradiation. American Journal of Infection Control, 48(10), 1273-1275. https://doi.org/10.1016/j.ajic.2020.07.031
Heilingloh CS, et al. Susceptibility of SARS-CoV-2 to UV Irradiation. Am J Infect Control. 2020;48(10):1273-1275. PubMed PMID: 32763344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of SARS-CoV-2 to UV irradiation. AU - Heilingloh,Christiane Silke, AU - Aufderhorst,Ulrich Wilhelm, AU - Schipper,Leonie, AU - Dittmer,Ulf, AU - Witzke,Oliver, AU - Yang,Dongliang, AU - Zheng,Xin, AU - Sutter,Kathrin, AU - Trilling,Mirko, AU - Alt,Mira, AU - Steinmann,Eike, AU - Krawczyk,Adalbert, Y1 - 2020/08/04/ PY - 2020/06/11/received PY - 2020/07/27/revised PY - 2020/07/30/accepted PY - 2020/8/9/pubmed PY - 2020/10/21/medline PY - 2020/8/9/entrez KW - COVID-19 KW - Inactivation KW - Ultraviolet light SP - 1273 EP - 1275 JF - American journal of infection control JO - Am J Infect Control VL - 48 IS - 10 N2 - The coronavirus SARS-CoV-2 pandemic became a global health burden. We determined the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The virus was highly susceptible to ultraviolet light. A viral stock with a high infectious titer of 5 × 106 TCID50/mL was completely inactivated by UVC irradiation after nine minutes of exposure. The UVC dose required for complete inactivation was 1,048 mJ/cm2. UVA exposure demonstrated only a weak effect on virus inactivation over 15 minutes. Hence, inactivation of SARS-CoV-2 by UVC irradiation constitutes a reliable method for disinfection purposes in health care facilities and for preparing SARS-CoV-2 material for research purpose. SN - 1527-3296 UR - https://www.unboundmedicine.com/medline/citation/32763344/Susceptibility_of_SARS_CoV_2_to_UV_irradiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-6553(20)30756-2 DB - PRIME DP - Unbound Medicine ER -