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Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa.
Viruses. 2020 08 05; 12(8)V

Abstract

Zoonoses can constitute a threat for public health that can have a global importance, as seen with the current COVID-19 pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV2). Bats have been recognized as an important reservoir of zoonotic coronaviruses (CoVs). In West Africa, where there is a high diversity of bat species, little is known on the circulation of CoVs in these hosts, especially at the interface with human populations. In this study, in Guinea, we tested a total of 319 bats belonging to 14 genera and six families of insectivorous and frugivorous bats across the country, for the presence of coronaviruses. We found CoVs in 35 (11%) of the tested bats-in three insectivorous bat species and five fruit bat species that were mostly captured close to human habitat. Positivity rates varied from 5.7% to 100%, depending on bat species. A wide diversity of alpha and beta coronaviruses was found across the country, including three sequences belonging to SarbeCoVs and MerbeCoVs subgenera known to harbor highly pathogenic human coronaviruses. Our findings suggest that CoVs are widely spread in West Africa and their circulation should be assessed to evaluate the risk of exposure of potential zoonotic CoVs to humans.

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Authors+Show Affiliations

Lacroix A
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Vidal N
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Keita AK
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France. Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Thaurignac G
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Esteban A
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
De Nys H
ASTRE, CIRAD, INRA, University of Montpellier, 34398 Montpellier, France. CIRAD, UMR ASTRE, Harare, Zimbabwe.
Diallo R
Laboratoire Central de Diagnostic Vétérinaire, Ministère de l'Elevage et des Productions Animales, Conakry BP3982, Guinea.
Toure A
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France. Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea. Institut National de Sante Publique (INSP), Conakry BP6623, Guinea.
Goumou S
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Soumah AK
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Povogui M
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Koivogui J
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Monemou JL
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry BP6629, Guinea.
Raulino R
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Nkuba A
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France. Institut National de Recherche Biomédicale and Service de Microbiologie, Cliniques Universitaires de Kinshasa, Gombe, Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Foulongne V
Département de bacteriologie-virologie, CHU de Montpellier, 34295 Montpellier, France.
Delaporte E
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Ayouba A
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.
Peeters M
TransVIHMI, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34394 Montpellier, France.

MeSH

AnimalsBetacoronavirusBiodiversityCOVID-19ChiropteraCoronavirusCoronavirus InfectionsFemaleGenome, ViralGuineaHumansMalePandemicsPhylogenyPilot ProjectsPneumonia, ViralSARS-CoV-2Zoonoses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32764506

Citation

Lacroix, Audrey, et al. "Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: a Pilot Study in Guinea, West Africa." Viruses, vol. 12, no. 8, 2020.
Lacroix A, Vidal N, Keita AK, et al. Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa. Viruses. 2020;12(8).
Lacroix, A., Vidal, N., Keita, A. K., Thaurignac, G., Esteban, A., De Nys, H., Diallo, R., Toure, A., Goumou, S., Soumah, A. K., Povogui, M., Koivogui, J., Monemou, J. L., Raulino, R., Nkuba, A., Foulongne, V., Delaporte, E., Ayouba, A., & Peeters, M. (2020). Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa. Viruses, 12(8). https://doi.org/10.3390/v12080855
Lacroix A, et al. Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: a Pilot Study in Guinea, West Africa. Viruses. 2020 08 5;12(8) PubMed PMID: 32764506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa. AU - Lacroix,Audrey, AU - Vidal,Nicole, AU - Keita,Alpha K, AU - Thaurignac,Guillaume, AU - Esteban,Amandine, AU - De Nys,Hélène, AU - Diallo,Ramadan, AU - Toure,Abdoulaye, AU - Goumou,Souana, AU - Soumah,Abdoul Karim, AU - Povogui,Moriba, AU - Koivogui,Joel, AU - Monemou,Jean-Louis, AU - Raulino,Raisa, AU - Nkuba,Antoine, AU - Foulongne,Vincent, AU - Delaporte,Eric, AU - Ayouba,Ahidjo, AU - Peeters,Martine, Y1 - 2020/08/05/ PY - 2020/06/11/received PY - 2020/07/04/revised PY - 2020/08/03/accepted PY - 2020/8/9/entrez PY - 2020/8/9/pubmed PY - 2020/9/10/medline KW - Africa KW - Guinea KW - bat KW - coronavirus KW - virus diversity JF - Viruses JO - Viruses VL - 12 IS - 8 N2 - Zoonoses can constitute a threat for public health that can have a global importance, as seen with the current COVID-19 pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV2). Bats have been recognized as an important reservoir of zoonotic coronaviruses (CoVs). In West Africa, where there is a high diversity of bat species, little is known on the circulation of CoVs in these hosts, especially at the interface with human populations. In this study, in Guinea, we tested a total of 319 bats belonging to 14 genera and six families of insectivorous and frugivorous bats across the country, for the presence of coronaviruses. We found CoVs in 35 (11%) of the tested bats-in three insectivorous bat species and five fruit bat species that were mostly captured close to human habitat. Positivity rates varied from 5.7% to 100%, depending on bat species. A wide diversity of alpha and beta coronaviruses was found across the country, including three sequences belonging to SarbeCoVs and MerbeCoVs subgenera known to harbor highly pathogenic human coronaviruses. Our findings suggest that CoVs are widely spread in West Africa and their circulation should be assessed to evaluate the risk of exposure of potential zoonotic CoVs to humans. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/32764506/Wide_Diversity_of_Coronaviruses_in_Frugivorous_and_Insectivorous_Bat_Species:_A_Pilot_Study_in_Guinea_West_Africa_ DB - PRIME DP - Unbound Medicine ER -