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Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review.
Eye Brain. 2020; 12:73-87.EB

Abstract

Background

Optical coherence tomography angiography (OCT-A) has emerged as a novel, fast, safe and non-invasive imaging technique of analyzing the retinal and choroidal microvasculature in vivo. OCT-A captures multiple sequential B-scans performed repeatedly over a specific retinal area at high speed, thus enabling the composition of a vascular map with areas of contrast change (high flow zones) and areas of steady contrast (slow or no flow zones). It therefore provides unique insight into the exact retinal or choroidal layer and location at which abnormal blood flow develops. OCTA has evolved into a useful tool for understanding a number of retinal pathologies such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, macular telangiectasia and choroidal neovascular membranes of other causes. OCT-A technology is also increasingly being used in the evaluation of optic disc perfusion and has been suggested as a valuable tool in the early detection of glaucomatous damage and monitoring progression.

Objective

To review the existing literature on the applications of optical coherence tomography angiography in neurodegenerative diseases.

Summary

A meticulous literature was performed until the present day. Google Scholar, PubMed, Mendeley search engines were used for this purpose. We used 123 published manuscripts as our references. OCT-A has been utilized so far to describe abnormalities in multiple sclerosis (MS), Alzheimer's disease, arteritic and non-arteritic optic neuropathy (AION and NAION), Leber's hereditary optic neuropathy (LHON) papilloedema, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Wolfram syndrome, migraines, lesions of the visual pathway and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). It appears that OCT-A findings correlate quite well with the severity of the aforementioned diseases. However, OCT-A has its own limitations, namely its lack of wide-field view of the peripheral retina and the inaccurate interpretation due to motion artifacts in uncooperative groups of patients (e.g. children). Larger prospective longitudinal studies will need to be conducted in order to eliminate the aforementioned limitations.

Authors+Show Affiliations

Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK.Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK.The Eye Institute of West Florida, Largo, FL, USA.Ophthalmology Department, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK.Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32765149

Citation

Tsokolas, Georgios, et al. "Optical Coherence Tomography Angiography in Neurodegenerative Diseases: a Review." Eye and Brain, vol. 12, 2020, pp. 73-87.
Tsokolas G, Tsaousis KT, Diakonis VF, et al. Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review. Eye Brain. 2020;12:73-87.
Tsokolas, G., Tsaousis, K. T., Diakonis, V. F., Matsou, A., & Tyradellis, S. (2020). Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review. Eye and Brain, 12, 73-87. https://doi.org/10.2147/EB.S193026
Tsokolas G, et al. Optical Coherence Tomography Angiography in Neurodegenerative Diseases: a Review. Eye Brain. 2020;12:73-87. PubMed PMID: 32765149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review. AU - Tsokolas,Georgios, AU - Tsaousis,Konstantinos T, AU - Diakonis,Vasilios F, AU - Matsou,Artemis, AU - Tyradellis,Straton, Y1 - 2020/07/14/ PY - 2020/02/21/received PY - 2020/06/25/accepted PY - 2020/8/9/entrez PY - 2020/8/9/pubmed PY - 2020/8/9/medline KW - neuro-ophthalmology KW - neurodegenerative diseases KW - optical coherence tomography angiography SP - 73 EP - 87 JF - Eye and brain JO - Eye Brain VL - 12 N2 - Background: Optical coherence tomography angiography (OCT-A) has emerged as a novel, fast, safe and non-invasive imaging technique of analyzing the retinal and choroidal microvasculature in vivo. OCT-A captures multiple sequential B-scans performed repeatedly over a specific retinal area at high speed, thus enabling the composition of a vascular map with areas of contrast change (high flow zones) and areas of steady contrast (slow or no flow zones). It therefore provides unique insight into the exact retinal or choroidal layer and location at which abnormal blood flow develops. OCTA has evolved into a useful tool for understanding a number of retinal pathologies such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, macular telangiectasia and choroidal neovascular membranes of other causes. OCT-A technology is also increasingly being used in the evaluation of optic disc perfusion and has been suggested as a valuable tool in the early detection of glaucomatous damage and monitoring progression. Objective: To review the existing literature on the applications of optical coherence tomography angiography in neurodegenerative diseases. Summary: A meticulous literature was performed until the present day. Google Scholar, PubMed, Mendeley search engines were used for this purpose. We used 123 published manuscripts as our references. OCT-A has been utilized so far to describe abnormalities in multiple sclerosis (MS), Alzheimer's disease, arteritic and non-arteritic optic neuropathy (AION and NAION), Leber's hereditary optic neuropathy (LHON) papilloedema, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Wolfram syndrome, migraines, lesions of the visual pathway and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). It appears that OCT-A findings correlate quite well with the severity of the aforementioned diseases. However, OCT-A has its own limitations, namely its lack of wide-field view of the peripheral retina and the inaccurate interpretation due to motion artifacts in uncooperative groups of patients (e.g. children). Larger prospective longitudinal studies will need to be conducted in order to eliminate the aforementioned limitations. SN - 1179-2744 UR - https://www.unboundmedicine.com/medline/citation/32765149/Optical_Coherence_Tomography_Angiography_in_Neurodegenerative_Diseases:_A_Review_ L2 - https://dx.doi.org/10.2147/EB.S193026 DB - PRIME DP - Unbound Medicine ER -
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