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Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy.
Cardiovasc Drugs Ther. 2020 12; 34(6):835-848.CD

Abstract

PURPOSE

To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes.

METHODS

Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min per day, 5 days a week for 4 weeks. Heart function was assessed by echocardiography. Myocardium was assessed by RT-PCR, immunoblotting, and histology. Serum TNF-α, IL-1α, IL-1β, IL-6, and IL-8 were measured.

RESULTS

DM-Acu, but not DM-Sham, reduced fasting blood glucose without affecting body weight. DM decreased systolic function. DM-Acu, but not DM-Sham, attenuated the decrease in systolic function. Heart weight was significantly smaller in the DM-Acu than in the DM and DM-Sham groups. Percent fibrosis and apoptosis were reduced in the DM-Acu, but not the DM-Sham, group. Serum levels of IL-1α, IL-1β, IL-6, IL-8, ICAM-1, MCP-1, and TNF-α were significantly lower in the DM-Acu than in the DM or DM-Sham groups. Protein levels of P-Akt and P-AMPK and mRNA levels of phosphoinositide-3-kinase regulatory subunit 6 (PIK3r6) were significantly higher in the DM-Acu group. Myocardial mRNA and protein levels of insulin-like growth factor 1 receptor (IGF1R) were significantly lower in the DM and DM-Sham groups compared with the DM-Acu group.

CONCLUSIONS

EA reduced serum glucose; prevented DM-induced hypertrophy and deterioration of systolic function, inflammation, and fibrosis; and restored IGF1R, P-Akt, and P-AMPK levels in mice with type 2 diabetes mellitus.

Authors+Show Affiliations

The Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.The Section of Cardiology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza MS, BCM620, Houston, TX, USA. ybirnbau@bcm.edu.The Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Department of Acupuncture, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.Section of Endocrinology, Baylor College of Medicine, Houston, TX, USA.The Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. chenhuan26384@163.com. Department of Acupuncture, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. chenhuan26384@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32767170

Citation

Ye, Yumei, et al. "Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice With Diabetic Cardiomyopathy." Cardiovascular Drugs and Therapy, vol. 34, no. 6, 2020, pp. 835-848.
Ye Y, Birnbaum Y, Widen SG, et al. Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy. Cardiovasc Drugs Ther. 2020;34(6):835-848.
Ye, Y., Birnbaum, Y., Widen, S. G., Zhang, Z., Zhu, S., Bajaj, M., & Chen, H. (2020). Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy. Cardiovascular Drugs and Therapy, 34(6), 835-848. https://doi.org/10.1007/s10557-020-07043-4
Ye Y, et al. Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice With Diabetic Cardiomyopathy. Cardiovasc Drugs Ther. 2020;34(6):835-848. PubMed PMID: 32767170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy. AU - Ye,Yumei, AU - Birnbaum,Yochai, AU - Widen,Steven G, AU - Zhang,Zhaohui, AU - Zhu,Shipeng, AU - Bajaj,Mandeep, AU - Chen,Huan, Y1 - 2020/08/07/ PY - 2020/07/20/accepted PY - 2020/8/9/pubmed PY - 2021/6/9/medline PY - 2020/8/9/entrez KW - Acupuncture KW - Animal models KW - Apoptosis KW - Diabetes mellitus KW - Diabetic cardiomyopathy KW - Glycemic control KW - Inflammation SP - 835 EP - 848 JF - Cardiovascular drugs and therapy JO - Cardiovasc Drugs Ther VL - 34 IS - 6 N2 - PURPOSE: To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS: Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min per day, 5 days a week for 4 weeks. Heart function was assessed by echocardiography. Myocardium was assessed by RT-PCR, immunoblotting, and histology. Serum TNF-α, IL-1α, IL-1β, IL-6, and IL-8 were measured. RESULTS: DM-Acu, but not DM-Sham, reduced fasting blood glucose without affecting body weight. DM decreased systolic function. DM-Acu, but not DM-Sham, attenuated the decrease in systolic function. Heart weight was significantly smaller in the DM-Acu than in the DM and DM-Sham groups. Percent fibrosis and apoptosis were reduced in the DM-Acu, but not the DM-Sham, group. Serum levels of IL-1α, IL-1β, IL-6, IL-8, ICAM-1, MCP-1, and TNF-α were significantly lower in the DM-Acu than in the DM or DM-Sham groups. Protein levels of P-Akt and P-AMPK and mRNA levels of phosphoinositide-3-kinase regulatory subunit 6 (PIK3r6) were significantly higher in the DM-Acu group. Myocardial mRNA and protein levels of insulin-like growth factor 1 receptor (IGF1R) were significantly lower in the DM and DM-Sham groups compared with the DM-Acu group. CONCLUSIONS: EA reduced serum glucose; prevented DM-induced hypertrophy and deterioration of systolic function, inflammation, and fibrosis; and restored IGF1R, P-Akt, and P-AMPK levels in mice with type 2 diabetes mellitus. SN - 1573-7241 UR - https://www.unboundmedicine.com/medline/citation/32767170/Acupuncture_Reduces_Hypertrophy_and_Cardiac_Fibrosis_and_Improves_Heart_Function_in_Mice_with_Diabetic_Cardiomyopathy_ DB - PRIME DP - Unbound Medicine ER -