Tags

Type your tag names separated by a space and hit enter

Prognostic Implication of Volumetric Quantitative CT Analysis in Patients with COVID-19: A Multicenter Study in Daegu, Korea.
Korean J Radiol. 2020 11; 21(11):1256-1264.KJ

Abstract

OBJECTIVE

Lung segmentation using volumetric quantitative computed tomography (CT) analysis may help predict outcomes of patients with coronavirus disease (COVID-19). The aim of this study was to investigate the relationship between CT volumetric quantitative analysis and prognosis in patients with COVID-19.

MATERIALS AND METHODS

CT images from patients diagnosed with COVID-19 from February 18 to April 15, 2020 were retrospectively analyzed. CT with a negative finding, failure of quantitative analysis, or poor image quality was excluded. CT volumetric quantitative analysis was performed by automated volumetric methods. Patients were stratified into two risk groups according to CURB-65: mild (score of 0-1) and severe (2-5) pneumonia. Outcomes were evaluated according to the critical event-free survival (CEFS). The critical events were defined as mechanical ventilator care, ICU admission, or death. Multivariable Cox proportional hazards analyses were used to evaluate the relationship between the variables and prognosis.

RESULTS

Eighty-two patients (mean age, 63.1 ± 14.5 years; 42 females) were included. In the total cohort, male sex (hazard ratio [HR], 9.264; 95% confidence interval [CI], 2.021-42.457; p = 0.004), C-reactive protein (CRP) (HR, 1.080 per mg/dL; 95% CI, 1.010-1.156; p = 0.025), and COVID-affected lung proportion (CALP) (HR, 1.067 per percentage; 95% CI, 1.033-1.101; p < 0.001) were significantly associated with CEFS. CRP (HR, 1.164 per mg/dL; 95% CI, 1.006-1.347; p = 0.041) was independently associated with CEFS in the mild pneumonia group (n = 54). Normally aerated lung proportion (NALP) (HR, 0.872 per percentage; 95% CI, 0.794-0.957; p = 0.004) and NALP volume (NALPV) (HR, 1.002 per mL; 95% CI, 1.000-1.004; p = 0.019) were associated with a lower risk of critical events in the severe pneumonia group (n = 28).

CONCLUSION

CRP in the mild pneumonia group; NALP and NALPV in the severe pneumonia group; and sex, CRP, and CALP in the total cohort were independently associated with CEFS in patients with COVID-19.

Authors+Show Affiliations

Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Korea. limjk@knu.ac.kr.Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.Medical Research Collaboration Center in Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Korea.Department of Radiology, Daegu Fatima Hospital, Daegu, Korea.Department of Radiology, College of Medicine, Yeungnam University, Daegu, Korea.Department of Radiology, Yeungnam University Medical Center, Daegu, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32767868

Citation

Park, Byunggeon, et al. "Prognostic Implication of Volumetric Quantitative CT Analysis in Patients With COVID-19: a Multicenter Study in Daegu, Korea." Korean Journal of Radiology, vol. 21, no. 11, 2020, pp. 1256-1264.
Park B, Park J, Lim JK, et al. Prognostic Implication of Volumetric Quantitative CT Analysis in Patients with COVID-19: A Multicenter Study in Daegu, Korea. Korean J Radiol. 2020;21(11):1256-1264.
Park, B., Park, J., Lim, J. K., Shin, K. M., Lee, J., Seo, H., Lee, Y. H., Heo, J., Lee, W. K., Kim, J. Y., Kim, K. B., Moon, S., & Choi, S. (2020). Prognostic Implication of Volumetric Quantitative CT Analysis in Patients with COVID-19: A Multicenter Study in Daegu, Korea. Korean Journal of Radiology, 21(11), 1256-1264. https://doi.org/10.3348/kjr.2020.0567
Park B, et al. Prognostic Implication of Volumetric Quantitative CT Analysis in Patients With COVID-19: a Multicenter Study in Daegu, Korea. Korean J Radiol. 2020;21(11):1256-1264. PubMed PMID: 32767868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic Implication of Volumetric Quantitative CT Analysis in Patients with COVID-19: A Multicenter Study in Daegu, Korea. AU - Park,Byunggeon, AU - Park,Jongmin, AU - Lim,Jae Kwang, AU - Shin,Kyung Min, AU - Lee,Jaehee, AU - Seo,Hyewon, AU - Lee,Yong Hoon, AU - Heo,Jun, AU - Lee,Won Kee, AU - Kim,Jin Young, AU - Kim,Ki Beom, AU - Moon,Sungjun, AU - Choi,Sooyoung, Y1 - 2020/08/04/ PY - 2020/05/02/received PY - 2020/06/08/revised PY - 2020/06/13/accepted PY - 2020/8/9/pubmed PY - 2020/9/17/medline PY - 2020/8/9/entrez KW - Coronavirus disease KW - Prognostic implication KW - Severe acute respiratory syndrome coronavirus 2 KW - Volumetric quantitative analysis SP - 1256 EP - 1264 JF - Korean journal of radiology JO - Korean J Radiol VL - 21 IS - 11 N2 - OBJECTIVE: Lung segmentation using volumetric quantitative computed tomography (CT) analysis may help predict outcomes of patients with coronavirus disease (COVID-19). The aim of this study was to investigate the relationship between CT volumetric quantitative analysis and prognosis in patients with COVID-19. MATERIALS AND METHODS: CT images from patients diagnosed with COVID-19 from February 18 to April 15, 2020 were retrospectively analyzed. CT with a negative finding, failure of quantitative analysis, or poor image quality was excluded. CT volumetric quantitative analysis was performed by automated volumetric methods. Patients were stratified into two risk groups according to CURB-65: mild (score of 0-1) and severe (2-5) pneumonia. Outcomes were evaluated according to the critical event-free survival (CEFS). The critical events were defined as mechanical ventilator care, ICU admission, or death. Multivariable Cox proportional hazards analyses were used to evaluate the relationship between the variables and prognosis. RESULTS: Eighty-two patients (mean age, 63.1 ± 14.5 years; 42 females) were included. In the total cohort, male sex (hazard ratio [HR], 9.264; 95% confidence interval [CI], 2.021-42.457; p = 0.004), C-reactive protein (CRP) (HR, 1.080 per mg/dL; 95% CI, 1.010-1.156; p = 0.025), and COVID-affected lung proportion (CALP) (HR, 1.067 per percentage; 95% CI, 1.033-1.101; p < 0.001) were significantly associated with CEFS. CRP (HR, 1.164 per mg/dL; 95% CI, 1.006-1.347; p = 0.041) was independently associated with CEFS in the mild pneumonia group (n = 54). Normally aerated lung proportion (NALP) (HR, 0.872 per percentage; 95% CI, 0.794-0.957; p = 0.004) and NALP volume (NALPV) (HR, 1.002 per mL; 95% CI, 1.000-1.004; p = 0.019) were associated with a lower risk of critical events in the severe pneumonia group (n = 28). CONCLUSION: CRP in the mild pneumonia group; NALP and NALPV in the severe pneumonia group; and sex, CRP, and CALP in the total cohort were independently associated with CEFS in patients with COVID-19. SN - 2005-8330 UR - https://www.unboundmedicine.com/medline/citation/32767868/Prognostic_Implication_of_Volumetric_Quantitative_CT_Analysis_in_Patients_with_COVID_19:_A_Multicenter_Study_in_Daegu_Korea_ L2 - https://www.kjronline.org/DOIx.php?id=10.3348/kjr.2020.0567 DB - PRIME DP - Unbound Medicine ER -