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COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.
Infect Genet Evol. 2020 10; 84:104493.IG

Abstract

The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19.

Authors+Show Affiliations

Cirad, UMR 17, Intertryp, Montpellier, France; IES, UMR 5214 Univ. Montpellier-CNRS, Montpellier, France. Electronic address: roger.frutos@cirad.fr.Department of Evolutionary Biology, Ecology and Environmental Sciences, University of Barcelona, Biodiversity Research Institute, Barcelona, Spain.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen, PR China.IHU-Méditerranée Infection and CNRS, Marseille, France.

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32768565

Citation

Frutos, Roger, et al. "COVID-19: Time to Exonerate the Pangolin From the Transmission of SARS-CoV-2 to Humans." Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, vol. 84, 2020, p. 104493.
Frutos R, Serra-Cobo J, Chen T, et al. COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans. Infect Genet Evol. 2020;84:104493.
Frutos, R., Serra-Cobo, J., Chen, T., & Devaux, C. A. (2020). COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 84, 104493. https://doi.org/10.1016/j.meegid.2020.104493
Frutos R, et al. COVID-19: Time to Exonerate the Pangolin From the Transmission of SARS-CoV-2 to Humans. Infect Genet Evol. 2020;84:104493. PubMed PMID: 32768565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans. AU - Frutos,Roger, AU - Serra-Cobo,Jordi, AU - Chen,Tianmu, AU - Devaux,Christian A, Y1 - 2020/08/05/ PY - 2020/06/21/received PY - 2020/07/31/revised PY - 2020/08/01/accepted PY - 2020/8/10/pubmed PY - 2020/10/3/medline PY - 2020/8/10/entrez KW - COVID-19 KW - Coronavirus KW - Pangolin KW - SARS-CoV-2 KW - Zoonosis KW - Zoonotic model SP - 104493 EP - 104493 JF - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JO - Infect Genet Evol VL - 84 N2 - The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19. SN - 1567-7257 UR - https://www.unboundmedicine.com/medline/citation/32768565/COVID_19:_Time_to_exonerate_the_pangolin_from_the_transmission_of_SARS_CoV_2_to_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-1348(20)30324-5 DB - PRIME DP - Unbound Medicine ER -