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Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases.
Ann Rheum Dis. 2020 11; 79(11):1393-1399.AR

Abstract

OBJECTIVES

To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19.

METHODS

An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission.

RESULTS

The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3-10) days. The median length of stay was 9 (6-14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model.

CONCLUSION

Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission.

Authors+Show Affiliations

Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain lleon.hcsc@salud.madrid.org. Department of Health and Education, Universidad Camilo Jose Cela, Villafranca del Castillo, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department, Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department, Hospital Clinico San Carlos, Madrid, Spain. Medicine Department, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid, Spain.Rheumatology Department, Hospital Clinico San Carlos, Madrid, Spain.Rheumatology Department and IDISSC, La Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos, Madrid, Spain.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32769150

Citation

Freites Nuñez, Dalifer D., et al. "Risk Factors for Hospital Admissions Related to COVID-19 in Patients With Autoimmune Inflammatory Rheumatic Diseases." Annals of the Rheumatic Diseases, vol. 79, no. 11, 2020, pp. 1393-1399.
Freites Nuñez DD, Leon L, Mucientes A, et al. Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2020;79(11):1393-1399.
Freites Nuñez, D. D., Leon, L., Mucientes, A., Rodriguez-Rodriguez, L., Font Urgelles, J., Madrid García, A., Colomer, J. I., Jover, J. A., Fernandez-Gutierrez, B., & Abasolo, L. (2020). Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases. Annals of the Rheumatic Diseases, 79(11), 1393-1399. https://doi.org/10.1136/annrheumdis-2020-217984
Freites Nuñez DD, et al. Risk Factors for Hospital Admissions Related to COVID-19 in Patients With Autoimmune Inflammatory Rheumatic Diseases. Ann Rheum Dis. 2020;79(11):1393-1399. PubMed PMID: 32769150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases. AU - Freites Nuñez,Dalifer D, AU - Leon,Leticia, AU - Mucientes,Arkaitz, AU - Rodriguez-Rodriguez,Luis, AU - Font Urgelles,Judit, AU - Madrid García,Alfredo, AU - Colomer,Jose I, AU - Jover,Juan A, AU - Fernandez-Gutierrez,Benjamín, AU - Abasolo,Lydia, Y1 - 2020/08/07/ PY - 2020/05/14/received PY - 2020/07/23/revised PY - 2020/07/25/accepted PY - 2020/8/10/pubmed PY - 2020/10/23/medline PY - 2020/8/10/entrez KW - antirheumatic agents KW - communicable diseases KW - epidemiology KW - health care KW - imported KW - outcome assessment SP - 1393 EP - 1399 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 79 IS - 11 N2 - OBJECTIVES: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. METHODS: An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission. RESULTS: The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3-10) days. The median length of stay was 9 (6-14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model. CONCLUSION: Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/32769150/Risk_factors_for_hospital_admissions_related_to_COVID_19_in_patients_with_autoimmune_inflammatory_rheumatic_diseases_ DB - PRIME DP - Unbound Medicine ER -