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Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children.
Indian Pediatr. 2020 11 15; 57(11):1010-1014.IP

Abstract

Background

We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS).

METHODS

We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.

RESULTS

We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.

CONCLUSION

Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.

Authors+Show Affiliations

Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. Correspondence to: Dr Aishwarya Venkataraman, Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, 12A Nageswara Road, Nungambakkam, Chennai 600 034, India. draishwaryav@gmail.com.Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Department of Microbiology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Department of Paediatric Intensive Care Unit, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu.Department of Paediatric Intensive Care Unit, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Bristol Royal Hospital for Children, Bristol, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32769230

Citation

Dhanalakshmi, K, et al. "Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated With SARS-CoV-2 (PIMS-TS) in Indian Children." Indian Pediatrics, vol. 57, no. 11, 2020, pp. 1010-1014.
Dhanalakshmi K, Venkataraman A, Balasubramanian S, et al. Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatr. 2020;57(11):1010-1014.
Dhanalakshmi, K., Venkataraman, A., Balasubramanian, S., Madhusudan, M., Amperayani, S., Putilibai, S., Sadasivam, K., Ramachandran, B., & Ramanan, A. V. (2020). Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatrics, 57(11), 1010-1014.
Dhanalakshmi K, et al. Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated With SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatr. 2020 11 15;57(11):1010-1014. PubMed PMID: 32769230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. AU - Dhanalakshmi,K, AU - Venkataraman,Aishwarya, AU - Balasubramanian,S, AU - Madhusudan,Manoj, AU - Amperayani,Sumanth, AU - Putilibai,Sulochana, AU - Sadasivam,Kalaimaran, AU - Ramachandran,Bala, AU - Ramanan,A V, Y1 - 2020/08/06/ PY - 2020/8/10/pubmed PY - 2020/12/22/medline PY - 2020/8/10/entrez SP - 1010 EP - 1014 JF - Indian pediatrics JO - Indian Pediatr VL - 57 IS - 11 N2 - Background: We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). METHODS: We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. RESULTS: We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths. CONCLUSION: Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies. SN - 0974-7559 UR - https://www.unboundmedicine.com/medline/citation/32769230/Epidemiological_and_Clinical_Profile_of_Pediatric_Inflammatory_Multisystem_Syndrome___Temporally_Associated_with_SARS_CoV_2__PIMS_TS__in_Indian_Children_ DB - PRIME DP - Unbound Medicine ER -