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Probiotics, prebiotics, antibiotic, Chinese herbal medicine, and fecal microbiota transplantation in irritable bowel syndrome: Protocol for a systematic review and network meta-analysis.
Medicine (Baltimore). 2020 Aug 07; 99(32):e21502.M

Abstract

BACKGROUND

Irritable bowel syndrome (IBS) is a functional gastrointestinal disease, with a high global incidence, which seriously influences the quality of life and work efficiency of patients. Extensive research showed that IBS is related to changes in the intestinal microenvironment. The novel treatment strategy targeting the gut microbiota is being actively implemented. Probiotics, antibiotics, prebiotics, fecal microbiota transplantation, and Chinese Herbal Medicine have been proven to be effective in the treatment of IBS, and all have an impact on the intestinal flora of patients. However, these 5 treatments have their own pros and cons and have not been systematically evaluated and compared. Therefore, this study will indirectly compare the safety and effectiveness of these 5 methods in the treatment of IBS through network meta-analysis.

METHODS

The following databases including Embase, Pubmed, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, WHO International Clinical Trials Registry Platform and ClinicalTrials.gov will be retrieved from inception to June 2020 without language restrictions. Literature selection, data extraction, and bias analysis will be done by 2 researchers. The primary outcome is global symptoms improvement. The secondary outcomes will include individual IBS symptom scores, emotional response, and adverse events. The conventional pair-wise meta-analysis will be performed using Stata V.14.0 and be pooled using a random-effects model. We will use WinBUGS V.1.4.3 (Cambridge, United Kingdom) with a Bayesian hierarchical random-effects model to conduct the network meta-analysis.

RESULTS

This study will provide systematic reviews and indirect network comparison results about treatments of IBS.

CONCLUSIONS

This study will systematically evaluate and compare 5 intestinal flora-related therapies for IBS and to provide an evidence-based medical decision-making basis for clinicians.

TRIAL REGISTRATION NUMBER

INPLASY202050047.

Authors+Show Affiliations

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu city, Sichuan province.Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu city, Sichuan province.Beijing University of Chinese Medicine, Beijing city, China.Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu city, Sichuan province.Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu city, Sichuan province.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32769886

Citation

He, Ying, et al. "Probiotics, Prebiotics, Antibiotic, Chinese Herbal Medicine, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: Protocol for a Systematic Review and Network Meta-analysis." Medicine, vol. 99, no. 32, 2020, pp. e21502.
He Y, Xu R, Wang W, et al. Probiotics, prebiotics, antibiotic, Chinese herbal medicine, and fecal microbiota transplantation in irritable bowel syndrome: Protocol for a systematic review and network meta-analysis. Medicine (Baltimore). 2020;99(32):e21502.
He, Y., Xu, R., Wang, W., Zhang, J., & Hu, X. (2020). Probiotics, prebiotics, antibiotic, Chinese herbal medicine, and fecal microbiota transplantation in irritable bowel syndrome: Protocol for a systematic review and network meta-analysis. Medicine, 99(32), e21502. https://doi.org/10.1097/MD.0000000000021502
He Y, et al. Probiotics, Prebiotics, Antibiotic, Chinese Herbal Medicine, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: Protocol for a Systematic Review and Network Meta-analysis. Medicine (Baltimore). 2020 Aug 7;99(32):e21502. PubMed PMID: 32769886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics, prebiotics, antibiotic, Chinese herbal medicine, and fecal microbiota transplantation in irritable bowel syndrome: Protocol for a systematic review and network meta-analysis. AU - He,Ying, AU - Xu,Rui, AU - Wang,Wei, AU - Zhang,Jie, AU - Hu,Xiaoyu, PY - 2020/8/10/entrez PY - 2020/8/10/pubmed PY - 2020/8/25/medline SP - e21502 EP - e21502 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 32 N2 - BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal disease, with a high global incidence, which seriously influences the quality of life and work efficiency of patients. Extensive research showed that IBS is related to changes in the intestinal microenvironment. The novel treatment strategy targeting the gut microbiota is being actively implemented. Probiotics, antibiotics, prebiotics, fecal microbiota transplantation, and Chinese Herbal Medicine have been proven to be effective in the treatment of IBS, and all have an impact on the intestinal flora of patients. However, these 5 treatments have their own pros and cons and have not been systematically evaluated and compared. Therefore, this study will indirectly compare the safety and effectiveness of these 5 methods in the treatment of IBS through network meta-analysis. METHODS: The following databases including Embase, Pubmed, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, WHO International Clinical Trials Registry Platform and ClinicalTrials.gov will be retrieved from inception to June 2020 without language restrictions. Literature selection, data extraction, and bias analysis will be done by 2 researchers. The primary outcome is global symptoms improvement. The secondary outcomes will include individual IBS symptom scores, emotional response, and adverse events. The conventional pair-wise meta-analysis will be performed using Stata V.14.0 and be pooled using a random-effects model. We will use WinBUGS V.1.4.3 (Cambridge, United Kingdom) with a Bayesian hierarchical random-effects model to conduct the network meta-analysis. RESULTS: This study will provide systematic reviews and indirect network comparison results about treatments of IBS. CONCLUSIONS: This study will systematically evaluate and compare 5 intestinal flora-related therapies for IBS and to provide an evidence-based medical decision-making basis for clinicians. TRIAL REGISTRATION NUMBER: INPLASY202050047. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/32769886/Probiotics_prebiotics_antibiotic_Chinese_herbal_medicine_and_fecal_microbiota_transplantation_in_irritable_bowel_syndrome:_Protocol_for_a_systematic_review_and_network_meta_analysis_ L2 - https://doi.org/10.1097/MD.0000000000021502 DB - PRIME DP - Unbound Medicine ER -