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[Tracing the origins of SARS-COV-2 in coronavirus phylogenies].
Med Sci (Paris). 2020 Aug-Sep; 36(8-9):783-796.MS

Abstract

SARS-CoV-2 is a new human coronavirus (CoV), which emerged in People's Republic of China at the end of 2019 and is responsible for the global Covid-19 pandemic that caused more than 540 000 deaths in six months. Understanding the origin of this virus is an important issue and it is necessary to determine the mechanisms of its dissemination in order to be able to contain new epidemics. Based on phylogenetic inferences, sequence analysis and structure-function relationships of coronavirus proteins, informed by the knowledge currently available, we discuss the different scenarios evoked to account for the origin - natural or synthetic - of the virus. On the basis of currently available data, it is impossible to determine whether SARS-CoV-2 is the result of a natural zoonotic emergence or an accidental escape from experimental strains. Regardless of its origin, the study of the evolution of the molecular mechanisms involved in the emergence of this pandemic virus is essential to develop therapeutic and vaccine strategies.

Authors+Show Affiliations

École Normale Supérieure de Paris, 45 rue d'Ulm, 75005 Paris, France.Université de Paris, CNRS, LIED UMR 8236, 85 bd Saint-Germain, 75006 Paris, France.Université Paris-Saclay, CNRS, IRD, UMR Évolution, Génomes, Comportement et Écologie, 91198, Gif-sur-Yvette, France - Université de Paris, UFR Sciences du Vivant, F-75013 Paris, France.CNRS, Institut Français de Bioinformatique, IFB-core, UMS 3601, Évry, France - Aix-Marseille Univ, Inserm, laboratoire Theory and approaches of genome complexity (TAGC), Marseille, France.AFMB, CNRS, Aix-Marseille Univ, UMR 7257, Case 925, 163 avenue de Luminy, 13288 Marseille Cedex 09, France.

Pub Type(s)

Comparative Study
Journal Article

Language

fre

PubMed ID

32773024

Citation

Sallard, Erwan, et al. "[Tracing the Origins of SARS-COV-2 in Coronavirus Phylogenies]." Medecine Sciences : M/S, vol. 36, no. 8-9, 2020, pp. 783-796.
Sallard E, Halloy J, Casane D, et al. [Tracing the origins of SARS-COV-2 in coronavirus phylogenies]. Med Sci (Paris). 2020;36(8-9):783-796.
Sallard, E., Halloy, J., Casane, D., van Helden, J., & Decroly, É. (2020). [Tracing the origins of SARS-COV-2 in coronavirus phylogenies]. Medecine Sciences : M/S, 36(8-9), 783-796. https://doi.org/10.1051/medsci/2020123
Sallard E, et al. [Tracing the Origins of SARS-COV-2 in Coronavirus Phylogenies]. Med Sci (Paris). 2020 Aug-Sep;36(8-9):783-796. PubMed PMID: 32773024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Tracing the origins of SARS-COV-2 in coronavirus phylogenies]. AU - Sallard,Erwan, AU - Halloy,José, AU - Casane,Didier, AU - van Helden,Jacques, AU - Decroly,Étienne, Y1 - 2020/08/10/ PY - 2020/8/11/pubmed PY - 2020/8/29/medline PY - 2020/8/11/entrez SP - 783 EP - 796 JF - Medecine sciences : M/S JO - Med Sci (Paris) VL - 36 IS - 8-9 N2 - SARS-CoV-2 is a new human coronavirus (CoV), which emerged in People's Republic of China at the end of 2019 and is responsible for the global Covid-19 pandemic that caused more than 540 000 deaths in six months. Understanding the origin of this virus is an important issue and it is necessary to determine the mechanisms of its dissemination in order to be able to contain new epidemics. Based on phylogenetic inferences, sequence analysis and structure-function relationships of coronavirus proteins, informed by the knowledge currently available, we discuss the different scenarios evoked to account for the origin - natural or synthetic - of the virus. On the basis of currently available data, it is impossible to determine whether SARS-CoV-2 is the result of a natural zoonotic emergence or an accidental escape from experimental strains. Regardless of its origin, the study of the evolution of the molecular mechanisms involved in the emergence of this pandemic virus is essential to develop therapeutic and vaccine strategies. SN - 1958-5381 UR - https://www.unboundmedicine.com/medline/citation/32773024/[Tracing_the_origins_of_SARS_COV_2_in_coronavirus_phylogenies]_ L2 - http://publications.edpsciences.org/10.1051/medsci/2020123 DB - PRIME DP - Unbound Medicine ER -